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🔥 HOT OFF THE PRESS for #ACR23
Effectiveness of a fourth dose of #COVID19 mRNA #vaccine in patients with systemic autoimmune rheumatic diseases using DMARDs: an emulated target trial https://t.co/bvc75BP4aG @zach_wallace_md @jeffsparks https://t.co/CAlgjvUr9X
The Lancet Rheumatology TheLancetRheum ( View Tweet)
Something to listen to on the way home from #ACR23
The last episode in a 4 part series on the environment and autoimmunity
What does silica exposure have to do with autoimmunity?
https://t.co/2Vqi22xqCw
Adam J Brown ( View Tweet)
Nipocalimab (say it a couple of times) is a FcRn (neonatal Fc receptor) inhibitor. In short promotes degradation of IgG incl autoantibodies (and investigated in myasthenia).
Prof Taylor presents that it might work in CCP high titer RA at #ACR23.
#ACRambassador @ACRheum https://t.co/DqlsOv7AVI
Tue Kragstrup KragstrupTW ( View Tweet)
Reminder of data for dose reduction #bDMARD by Prof Emery #ACR23
Feasible after early remission induction https://t.co/WwiNp8WKDC
Dr Gurdeep S Dulay ( View Tweet)
Thanks #ACR23 for a wonderful meeting ! Presented a really positive phase 2 clinical trial results of Dazukibart, an IFN beta monoclonal antibody in #Myositis (DM) #pfizer
.Strong efficacy with rapid onset. Safe & tolerable monthly IV injection. Looking forward to start Phase 3. https://t.co/580ICHM8Hs
Rohit Aggarwal ( View Tweet)
Just presented at #ACR23 by Dr Jennifer Hanberg @Jen_LS_Hanberg and published at @TheLancetRheum.!
Effectiveness of 4th mRNA COVID dose on breakthrough infection @zach_wallace_md
https://t.co/PXc2THn217
Jeffrey Sparks MD MMSc jeffsparks ( View Tweet)
Chikungunya - takeaway points
🪔Acute arthritis in large joints , polyarthritis and tenosynovitis in hands
🪔 Associated with travel history to Africa/Asia/Asia Pacific
🪔<5% develop chronic arthritis
#ACR23
#ACRambassador https://t.co/yzZDpy70i3
Tanmayee Bichile, MD ( View Tweet)
Maintain Vigilance for CV Risk Postpartum in Autoimmune Diseases
Pregnant women with ARDs and APS face significantly increased risks of CVEs. This increased risk is often attributed to ARDs, its medications or comorbidities associated with it.
https://t.co/KwMEwlr7Af https://t.co/vDt4B8jtt6
Dr. John Cush RheumNow ( View Tweet)
Look if I’m going to be rheumatology writing on a Wednesday night in LA post-#ACR23 then it might as well be with a bulgogi cheesesteak (loaded with jalapeño) and a negroni @MamaShelterLA https://t.co/OsqKb2EkET
David Liew drdavidliew ( View Tweet)
Does anyone feel like Lassie? #Wellness #RheumGR Talk by Dr. Wiles @UTSWIMchief @UTSWRheum https://t.co/7HG4vD95JQ
TheDaoIndex KDAO2011 ( View Tweet)
Congrats Dr Desir @dddesir on becoming @ACRheum President, and the first Black president of the ACR.
Read about her work, and her priorities to reduce our workforce shortage & improve the culture of belonging 👇
#ACR23 https://t.co/5Y94Wy1Zl0
Angus Worthing MD AngusWorthing ( View Tweet)
I’ll keep on tweeting more @RheumNow, but it’s time for me to leave the #ACR23 conference center.
Another year of an incredible scientific program, seeing many friends (although sadly ran out of time to see many too) and a whole lot of rheumatology fun. See you in DC #ACR24! https://t.co/h31abYsipX
David Liew drdavidliew ( View Tweet)
#Yr in #Preview #ACR2023 J Buyon
Pregnancies in #SLE have high #VTE risk - look at Ob/Gyn guidelines for prophylaxis of LMW #heparin - all SLE pregnancies recommend #ASA & #HCQ
biomarkers for #renal #lupus, #HCQ levels ?aid #Rx
-#SLE nephritis low prednisone
2 IS>1
@RheumNow
Janet Pope ( View Tweet)
B cell signalling reduction to treat #RA?
Telitacicept RCT showed #efficacy in active RA w MTX -maybe blunted high responses but no active comparator, only #PBO so difficult to compare to current Rx and only from 1 country China. Past bDMARDs not reported
L20 @RheumNow @ACRheum
Janet Pope ( View Tweet)
#Hope for people with #SLE
Insights from #ACR23
#Lupus #nephritis - half the oral #prednisone is = to 1 mg/kg induction after IV #solumedrol LESS PRED
#Anifrolimumab reduces similarly skin, jts, other common organs in #SLE RCTS APPROX 2X improvement vs PBO
@RheumNow @ACRheum https://t.co/OtdfTxZxr4
Janet Pope ( View Tweet)
As per #ACR23 ABST0433, what % of RA patients on US Medicare are on a DMARD within 1y of diagnosis?
I'm not talking your choice of b/tsDMARD.
I'm talking any cs/b/tsDMARD of any sort.
Hear from @JihaRheum to skip to the answer:
https://t.co/lI2M20JWKC
Truly stunning. @RheumNow
David Liew drdavidliew ( View Tweet)
Frail pts with SLE is associated with 🔸prolonged hospitalizations (28.89%), 🔸significantly higher in-pt mortality (2.88%)
🔸fewer days-to-readmission (59.8%)
vs. non-frail pts with SLE
(CLeung et al)
Screen your SLE pts for frailty too.
#ACR23 ABST2590 @RheumNow https://t.co/c4YP5h2ypn
sheila ( View Tweet)
INSIST trial: MMF vs Tac in SS-ILD
N=25 pts
👉No significant diff between MMF & TAC in mean change in FVC at 24 weeks [2.52%, 95% CI (-10.3 to 5.18)p=0.500]
👉No SAEs noted in both grps
Larger studies w/ longer ffup needed.
#ACR23 ABST2595 @RheumNow https://t.co/cqpnxyMDmv
sheila ( View Tweet)
I think crown belongs to the 🐱💜 🤗Top Influencers of #ACR23 👉 @ACRheum @rheum_cat @RheumNow @drdavidliew @EBRheum @realcc @KDAO2011 https://t.co/UfNdj8u7cP via @symplur https://t.co/b71OeZS7Jj
Lisa 🐳🗺🧭 rheumarhyme ( View Tweet)
Dr. @Janetbirdope has the best quotes ever ‘ if its ain’t broke, don’t fix it, just leave it alone’ 🤷🏻♀️
IGg4 is very interesting , could just be reacting / secondary to an underlying phenomenon?
https://t.co/hueCJuYI32
@RheumNow
#ACR23, Daily recap.
Nouf Al hemmadi ( View Tweet)