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RA: update for women of child bearing potential (and men!)
Fertility in the context of RMDs is a daily concern for a lot of rheumatologists and patients.
EULAR this year proposed new fertility data, especially in Rheumatoid Arthritis, along with an update of the EULAR points to consider for use of antirheumatic drugs in reproduction, pregnancy and lactation.
A Step Closer to Identifying Phenotypes of RA ILD
Dr. Mrinalini Dey discusses abstract OP0202 presented at Eular 2024 in Vienna, Austria.
https://t.co/VUfsi3HnAA https://t.co/RA9kuuJSUS
Dr. John Cush RheumNow ( View Tweet)
EULAR 2024: Wednesday’s Topic Panel (RA) with RheumNow https://t.co/j83v8JeTXh
Links:
Dr. John Cush RheumNow ( View Tweet)
When patients say their joints are swollen, what does it mean?
Easy to dismiss it as a symptom, but this clinically suspect arthralgia cohort from Leiden shows:
- some correlation w/ MRI/USS findings
- predicts RA development
- still worthwhile!
#EULAR2024 POS0609 @drdavidliew https://t.co/cRl5ow1emE
Dr. John Cush RheumNow ( View Tweet)
ComOA- a cohort study from 3.4 million, 4 countries looked at OA (n=845K) & comorbidities. Tops were LBP (44%), HTN, (34%), allergy (21%), cataract (16%), vertigo (14%), depression (13%), DM (13%). After OA Dx: Fm, RA, PMR OP0230 #EULAR2024 https://t.co/GMVCHSfyt0 https://t.co/KFlacpHfAX
Dr. John Cush RheumNow ( View Tweet)
Another proof (if needed) that controlling Dz Activity in RA is a very important preventive measure in RA!
179 pts
ILD newly developed 9.5%
progressed 12.3%
no change 74.9%
improved 4.5%
5.7% in the LDA group 28.0% non-LDA group (p=0.006)
#EULAR2024 POS0408 @AurelieRheumo https://t.co/lKUY32KFiX
Dr. John Cush RheumNow ( View Tweet)
Might Synovial Biopsy Predict Rheumatoid Treatment Responses?
Multi-modal analysis of rheumatoid arthritis (RA) synovitis pathotypes enables more accurate choices of first line cDMARDs treatment, suggesting a predictive value to synovial biopsy.
https://t.co/bMUzduZIz9 https://t.co/yFxCvoZukM
Dr. John Cush RheumNow ( View Tweet)
EULAR 2024: Tuesday’s Topic Panel (PSA) with RheumNow https://t.co/j4I1bC9ROD
Links:
Dr. John Cush RheumNow ( View Tweet)
Pain in RA: Different Drugs for Different Mechanisms
Dr. Aurelie Najm reports from Eular 2024 in Vienna, Austria, about abstracts OP0072 and OP0086.
https://t.co/Q7CZoHpDmc https://t.co/cvIRhBJt9Z
Dr. John Cush RheumNow ( View Tweet)
Matters of the heart: cardiovascular disease and mortality in RA
Patients with RA have up to 2x higher risk of coronary artery disease, plus increased atrial fibrillation and stroke risk.
https://t.co/wFs7ds3tF2 https://t.co/GWyXJbeyIn
Dr. John Cush RheumNow ( View Tweet)
Mechanistic Promise in RA Doesn’t Always Mean Actual Gain
Dr. David Liew reports on abstracts OP0007 and OP0069 at Eular 2024 in Vienna, Austria.
https://t.co/PcKtezJLCH https://t.co/N9tdgFN7Xq
Links:
Dr. John Cush RheumNow ( View Tweet)
Dual seropositivity and shared epitopes in RA: friends or foes?
Dual seropositivity, RF and/or anti-citrullinated protein antibodies (ACPA) as well as shared epitope (SE) are known to be associated with poor prognosis and structural damage in RA.
https://t.co/QcTHpgPV2Q https://t.co/TzueMr8M5T
Dr. John Cush RheumNow ( View Tweet)
Difficult-to-treat RA: are we any closer to predicting who is at risk?
It is almost four years since EULAR published its definition of difficult-to-treat (D2T) rheumatoid arthritis (RA) (1). This marked a formal recognition of the group of patients who, despite the advances in pharmacological therapy for RA, remain symptomatic.
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EULAR 2024: New drugs for RA?
Abiprubart is an Abatacept distant relative, targeting T cell activation through a different target/molecular interaction (CD40/CD154).
https://t.co/3wAGjfCdcN https://t.co/2YK2OeIVZK
Dr. John Cush RheumNow ( View Tweet)
How many #autoantibodies
Does one need in
#rheumatoid #arthritis
Need 4 citrullinated peptides
Covers off
97% of IgG CVP2 ACPAs
#EULAR2024 @RheumNow @eular_org https://t.co/LNFGuFXGrC
Janet Pope Janetbirdope ( View Tweet)
#EULAR2024 POS0467 - Periodontal disease related tot he development of #RA
ACPA positive and negative pts.
Tooth extraction in CCP positive pts was associated.
Need tooth history in RA. @RheumNow https://t.co/b9Nb3cd0kd
Bella Mehta bella_mehta ( View Tweet)
Could dogs smell RA? lol...!
Exhaled breath experimental study to diagnose RA?
Volatile organic compounds can detect RA?
#EULAR2024 @RheumNow https://t.co/FiHsZ522In
Bella Mehta bella_mehta ( View Tweet)
Deep B cell depletion strategies for Drug resistant RA @RheumNow #EULAR2024
for those which dont want to use CAR-T cells / other options.
Maybe used in other diseases. https://t.co/joRhfWaiDs
Bella Mehta bella_mehta ( View Tweet)
EULAR
OP0041 (2024)
COMPARISON OF b/tsDMARDs ABOUT NON-INFLAMMATORY PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS–ANSWER LONGITUDINAL COHORT STUDY. 25% RA have significant non-inflammatory pain https://t.co/XWnzuVMlbn @RheumNow #EULAR2024
Links:
Peter Nash drpnash ( View Tweet)
EULAR
OP0092 (2024)
INFECTIONS IN PATIENTS WITH RA TREATED WITH JAKi COMPARED TO bDMARDs: AN INTERNATIONAL COLLABORATION OF REGISTERS (THE “JAK-POT” STUDY) TNF,OMA,JAK 7-10/100 pt.yr no signif diff except for zoster >30,000pts https://t.co/XWnzuVMlbn @RheumNow #EULAR2024
Links:
Peter Nash drpnash ( View Tweet)