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back, LBP, spine, AS

Opioids Ineffective in Acute Lower Back and Neck Pain

d EurekAlert!

A randomised controlled trial including 347 participants with lower back or neck pain found there was no benefit of taking opioid pain relievers compared to placebo. 

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Predictors of Cardiovascular Events in ANCA-Associated Vasculitis

d Jack Cush, MD

A large, retrospective, multinational study of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) shows they may be at risk for cardiovascular events (CVEs).

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AE, Side effects

Check SSc-ILD Patients on Nintedinib for Malnutrition

d MedPage Today

During nintedanib treatment for interstitial lung disease associated with systemic sclerosis (SSc-ILD), clinicians prescribing the drug should be watchful for an unusual, indirect side effect, trial data suggested.

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FDA Delays Bimekizumab Decision, Again

d Jack Cush, MD

Editor's Note: please note the error in the original report has been corrected to read: UCB affirms there are no open information requests from the FDA regarding the BLA for bimekizumab or bimekizumab manufacturing.

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Congratulations to Dr Stephan Maier who has been appointed as the Executive Director of EULAR. https://t.co/K7LCWT8Q6l https://t.co/xXV9ROFXqq

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Dr. John Cush RheumNow ( View Tweet)
A 35 yr old daughter of one of your Seropos. #RA patients shows up with finger arthralgias, +ACPA 200 IU and questions about if will she get RA. Here's a Survey for Rheumatologists and what you would do:https://t.co/lt38vJM6T2

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Dr. John Cush RheumNow ( View Tweet)

FDA Delays Bimekizumab Decision, Again UCB, the maker of the IL-17 A/F inhibitor bimekizumab (BMK), has announced that the FDA decision on BMK use in adults with moderate to severe plaque psoriasis has been delayed until the 3rd quarter of 2023. https://t.co/u3wZp2xain https://t.co/pEldK1grb9

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Dr. John Cush RheumNow ( View Tweet)
Gut Microbiome Alterations in Lupus Patients Recurrent bouts of systemic lupus erythematosus, marked by the body’s immune system attack of its own tissues, closely tracked with measurable upticks in growth in the gut of a certain species of bacteria. https://t.co/eGk4EQsVES https://t.co/PiFKxJWD13

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Dr. John Cush RheumNow ( View Tweet)
Taiwan claims data analysis of 1,830 scleroderma (SSc) pts & 27,981 controls showed increased incidence of SSc hospitalized w/ heart failure of 3.5%, 5.3%, & 9.7% (at 3, 5, 10 yrs). SSc patients had an increased risk of HF (adjusted HR 3.26) https://t.co/4WcHfiTJVF https://t.co/rW3J5aQdlS

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Dr. John Cush RheumNow ( View Tweet)
Paradoxical Psoriasis in Kids Taking TNF Inhibitors A multicenter cohort study reported a large cohort of pediatric patients receiving TNF inhibitor therapy complicated by psoriasis, regardless of treatment indication or the specific TNF inhibitor. https://t.co/f1KmICaGNF https://t.co/N0jxIJbv7Q

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Dr. John Cush RheumNow ( View Tweet)
High BMI Increases Arthritis Risk Obesity carries many risks, now a new study in Arthritis & Rheumatology shows that higher BMI increases the risk for several rheumatic diseases, especially in women for both gout and psoriatic arthropathy. https://t.co/9IRBAYT1F7 https://t.co/2GX3S3OnX7

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Dr. John Cush RheumNow ( View Tweet)
RheumNow LIVE VOTE Survey: What do you need to better manage pre-clinical (at-risk) Rheumatoid arthritis? Please vote here >>https://t.co/lt38vJMEIA

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Dr. John Cush RheumNow ( View Tweet)

RheumNow’s newly launched Poster Hall features sponsor-generated clinical trial posters designed to educate and inform. Check out our Poster Hall today! https://t.co/S9UOo3WACg https://t.co/i67uPX3s8G

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Dr. John Cush RheumNow ( View Tweet)
Paradoxical PsO (PP) studied in 2867 RA & 5316 SpA pts. 136 (1.7%) had paradox. Rxn, median 12 mos post TNFi [pustular (60%) or palmoplantar (31%)]. 73% PP favorably switched to other TNFi 46% or non-TNFi 27%. RA PP took SSZ, HCQ, LEF; SpA PP more smokers https://t.co/iYM3EOdSSM https://t.co/sruLP9adx3

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Dr. John Cush RheumNow ( View Tweet)
An inhaled Covid vaccine booster was more than 5-fold effective for inducing neutralizing antibodies at 28-days, and more durable at 1-year, than shots, vs Omicron BA.5 in a randomized trial https://t.co/yeHxgukgft @TheLancetInfDis https://t.co/drpQuw0yiN
EricTopol Eric Topol ( View Tweet)
EULAR 2023 Lupus Highlights https://t.co/xsqKvYmBWi https://t.co/mNRc1xUvam

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Dr. John Cush RheumNow ( View Tweet)
TitAIN Study: Secukinumab Efficacy in Giant Cell Arteritis A phase 2 trial has demonstrated the efficacy of secukinumab, an anti-interleukin-17A monoclonal antibody, in patients with active giant cell arteritis (GCA). https://t.co/rDZSQa6wCt https://t.co/WoqK8cpfxC

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Dr. John Cush RheumNow ( View Tweet)
Belimumab in adult inflamm myositis (IIM)? Small study 15 IIM pts recv ≥ 5 doses of belimumab or placebo; Treatment success (TIS ≥ 40) was more common with BEL (55% vs 33%) as was defined improvement (DOI: 33% vs 17%); not signif, but interesting! https://t.co/CG9ClLHEW6 https://t.co/DPekHWjTsP

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Dr. John Cush RheumNow ( View Tweet)
The Importance of Knowing Which Entheses are Involved in PsA Dr. Eric Ruderman discusses abstract POS0027 presented at EULAR 2023 in Milan, Italy. https://t.co/3RqnkGB9vn https://t.co/AaJd04MLx0

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Dr. John Cush RheumNow ( View Tweet)
Arborviral infx w/ rituximab? 21 RTX pts dx w/ arboviral neuroinvasive Dz, (encephalitis, acute flaccid myelitis); 79% died. B cell depletion impairs immunity & spread of West Nile Virus, serologic Ab Dx tests; thus if suspected, order RT-PCR tests https://t.co/I6A8F4Kx7a https://t.co/njyciZFn52

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Dr. John Cush RheumNow ( View Tweet)

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