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Severe Hypocalcemia Risk with Denosumab and CKD Patients
On 1-19-2024, the Food and Drug Administration (FDA) issued a Drug Safety Communication about the risk of severe hypocalcemia in chronic kidney disease (CKD) patients taking denosumab for osteoporosis, with an accentuated risk in older women who are dialysis-dependent.
This report is an update to their November 2022 investigation, the results of a related study being recently reported in JAMA.
Methotrexate Nodulosis (1.19.2024)
Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com. How good (or not) are rheumatologists and what to do about MTX nodulosis?
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Rituximab Efficacy in MAINRITSAN Long-Term Studies
https://t.co/z16uMDihV4 https://t.co/BaWFcwDbYL
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Sodium Channels, Carbemazepine and Osteoarthritis Progression
A study published in Nature suggests that therapies affecting sodium channels could be employed to treat osteoarthritis.
https://t.co/hmzKsgb3gA https://t.co/WVgk8nD4ne
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You can still attend RheumNow Live!
Below is a preview of one of our "STEP" talks - by Mike Putman, MD, who brings his vast knowledge to the forefront, shedding light on Myths & Mistakes on ANCA-Associated Vasculitis.
https://t.co/LzcVytLDij
Register: https://t.co/NWXKNhQzc5 https://t.co/ogAfTtH5Nk
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Seasonal Flu Vaccination in RA Patients
https://t.co/tNwgUVoG7Z https://t.co/P1UqPU57WU
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IL-17 pathway as a target in giant cell arteritis - full read review of pathogenic role of IL-17 and Th17 cells, in #GCA; backed up by the phase II proof-of-principle TiTAIN study showing potential efficacy of secukinumab in GCA pts https://t.co/MThzw2joGO https://t.co/PmrJjf9C3a
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2023 EULAR Non-pharmacological Management of Hip and Knee Osteoarthritis: 2023 update
EULAR has published the 2023 updated recommendations for the optimal non-pharmacological management of hip and knee osteoarthritis (OA).
https://t.co/OjmdAnRWtl https://t.co/gfWYopEgtt
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Japanese retrospective study compared RA pts on JAK inhib vs bDMARDs (n=62 ea) having orthopedic surgery; JAKi- pts had more postoperative flares (29% v 12%, P=.01), esp if JAKi held >11d (p.04). No diff in other postop complications https://t.co/NVY1Oajdve https://t.co/fwc9KWYZ9l
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Retrospective cohort compared 6147 new PsA pts vs 23,999 contros PsA. The uveitis risk was significantly higher in PsA (adj HR 2.38). Uveitis risk in PsA higher with prior uveitis (adj OR 136.4) and etanercept Rx (aOR 2.57). 106/107 Rx w/ topical steroids https://t.co/YVzIzSOaiB https://t.co/YORU8cQrAx
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Increased CV Comorbidity in Dermatomyositis
A cohort study suggest that patients with dermatomyositis (DM) are at an increased risk for multiple comorbidities, including chronic kidney and cardiovascular disease,
https://t.co/bYvd5AhqSl https://t.co/4y4kjYhTm3
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Hepatitis B Virus Reactivation is possible w/ immunosuppression- most (>10%) w/ w/ Rituximab & stem cell transplants. If HBsAg positive, pts should recv anti-viral prophylaxis; HBsAg− individuals should be evaluated on a case-by-case basis https://t.co/7JKorgWbYr https://t.co/RdW65u5KDR
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Metanlysis of 49 studies, 10 RCTs examined the relationship between RA and non-surgical Rx of periodontitis (NSRT) and in general short term studies show that NSPT benefits RA patients; and DMARD therapy benefits periodontitis https://t.co/Bw66VrIMp2 https://t.co/v9SG3sdeni
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You can still attend RheumNow Live!
This 1.5-day long meeting offers pre-learning modules, shorter, concise lectures with clinical context and audience input, more discussion time, and sessions that are relaxed and comprehensive.
Register: https://t.co/8jzvDmjVek https://t.co/U10B7zyQdR
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QD Clinic - RA, SSZ, & MI
RA with a myocardial inflarction - which DMARD?
https://t.co/FqnouGylMN https://t.co/KzmLctKZBI
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QD Clinic - GCA & Steroid Weaning
Weaning steroids in chronic GCA patient
https://t.co/HtrzP43Ivr https://t.co/xZZlNmeqP1
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CMS Final Rule on Prior Authorization Reforms
Prior authorizations and paperwork are killing medical providers; the good news is that a new CMS rule may lessen the burden.
https://t.co/bw4Mt06Zgz https://t.co/6B2TXSZuZO
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Fertility and Rheumatoid Onset
British women whose capability of bearing children either started late or ended early -- were at increased risk for developing RA, compared with women with earlier menarche or later menopause, researchers found.
https://t.co/SwxTvntqY2 https://t.co/bmwrLWwtke
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Network meta-analyses of 153 trials & 8713 patients w/ chronic pain from TMJ disorders; Most effective (pain & function) were CBT, PT-assisted jaw mobilisation, trigger point injx, jaw exercise/stretching, manipulation, & acupuncture https://t.co/b4kTuWg9QH https://t.co/7SJs0sLtK2
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You can still attend RheumNow Live!
This 1.5-day long meeting offers pre-learning modules, shorter, concise lectures with clinical context and audience input, more discussion time, and sessions that are relaxed and comprehensive.
Register: https://t.co/iWiFunwbNH https://t.co/3HmR7qqTMT
Links:
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