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TSR Shoulder replacement

Without DMARDS, Shoulder Arthroplasty Increasing in Rheumatoid Arthritis

d Jack Cush, MD

The need for total shoulder arthroplasty (TSA) in rheumatoid arthritis (RA) patients appears to depend on the use of disease modifying antirheumatic drugs (DMARDs), according to Seminars in Arthroplasty.

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Skin,cancer,squamous,cell

Does Methotrexate Increase Skin Cancer Risk?

d Jack Cush, MD

There are several reports suggesting a link between methotrexate (MTX) use and certain skin cancers, yet these are confounded by a higher risk of skin cancers with inflammatory conditions like rheumatoid arthritis of which MTX is the most common treatment.

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Cutaneous.lupus.SLE.Face.dermnetnz

Deucravacitinib - Effective in Systemic Lupus Erythematosus

d Jack Cush, MD

A Phase II, multicenter study has demonstrated the efficacy and safety of deucravacitinib, an oral, selective, allosteric inhibitor of TYK2, in  adults with active systemic lupus erythematosus (SLE).

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infx.pneumonia.jpg

Serious Infection Risk in Pediatric Psoriasis with Ustekinumab, Etanercept, or Methotrexate

d Jack Cush, MD

Etanercept was FDA approved for use in pediatric psoriasis (PsO) in 2016 and ustekinumab was similarly approved  in 2020.  This comparative analysis looks at the risk of serious infections (SIE) requiring hospitalization in pediatric PSO patients treated with ustekinumab, etanercept, or

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antibody (Keep)

New 5 Peptide Autoantibody Panel Complements RA Diagnosis

d MedPage Today

Antibodies to peptides not currently used for rheumatoid arthritis (RA) diagnosis helped identify patients with untreated early disease that conventional biomarkers missed, researchers said.

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211 Adult Crohn's pts w/ steroid-free remission >6mo on Combo infliximab & immunosuppressant either cont combo or W/D IFX or Immsup. 2-yr relapse rates: 14% Combo vs, 36% IFX vs 10% Immunosup. WD of IFX had 3.45-4.76 fold incr rsk of flare https://t.co/6EbM3Vx0Ei https://t.co/5ZOE2oxCl0

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Dr. John Cush RheumNow ( View Tweet)
Did you have a chance to listen to last week's RheumNow podcast? Dr. Cush covers rheumatology news from the last week. Make sure to tune in before we release our next episode tomorrow! https://t.co/uRRg2K2K1a https://t.co/MjWF3Zl05i

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Dr. John Cush RheumNow ( View Tweet)
Treatment failures studied in 718 RA pts - csDMARDs D/Cs intolerance (22%), inefficacy (20%), acute Rxns (5%), severe infx(0.6%) - bDMARDs D/Cs inefficacy (29%), intolerance (10%), acute Rxns (6%), severe infx (1.5%) - Multi-drug ifailure 5.7-8.4% https://t.co/FdoP77uELe https://t.co/dQjTNncABc

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Dr. John Cush RheumNow ( View Tweet)
NLRP12 is a negative regulator of innate immune activation and type I interferon production. SLE PBMCs have low levels NLRP12 (inverse correl w/ IFNa & Hi Dz activity. NLRP12 knockouts or deficiency Incr autoAbs, inflammation & renal damage https://t.co/PjTQNHhduB https://t.co/m0erNXMkUC

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Dr. John Cush RheumNow ( View Tweet)
GRAPPA Recommendations for Treating Enthesitis in PsA GRAPPA has provided new updates to the mgmt of enthesitis in patients with PsA, affecting at least 30% of PsA patients and is associated with more severe disease, x-ray damage, and poorer outcomes. https://t.co/AC6KHGMeo0

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Dr. John Cush RheumNow ( View Tweet)

New 5 Peptide Autoantibody Panel Complements RA Diagnosis Antibodies to peptides not currently used for rheumatoid arthritis (RA) diagnosis helped identify patients with untreated early disease that conventional biomarkers missed, researchers said. https://t.co/twgULvokPY https://t.co/O0I4i81RAN

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Dr. John Cush RheumNow ( View Tweet)
Systemic Sclerosis cohort study of 506 SSc pts with saw 5.3 with Degos-like lesions (89% in fingers). Degos lesions more assoc w/ diffuseSSc & acro-osteolysis, digital ulcers, and calcinosis (but not renal crisis, ILD, or pulmonary HTN https://t.co/Usrfr0XcCJ https://t.co/pmwkHsaJOx

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Dr. John Cush RheumNow ( View Tweet)
ChatGPT - A Boom or Threat to Scientific Publication? ChatGPT is a new, AI chatbot that has dramatically changed the digital worlds of education, research, statistics and more. Recently there were reports of ChatGPT passing the LSAT, USMLE, and more. https://t.co/CZd0WjOas5 https://t.co/Nx49SqXoHG

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Dr. John Cush RheumNow ( View Tweet)
High- Versus Low-Dose Exercise Therapy for Knee Osteoarthritis The Annals of Internal medicine has reported the results of high-dose versus low-dose exercise therapy demonstrating no benefits from more intense exercise. https://t.co/BtqeYWKG34 https://t.co/ngyM1DshDz

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Dr. John Cush RheumNow ( View Tweet)
Multicenter study of 80 AOSD & 60 controls used to develop AOSD criteria: - 3 pts rash - 3pts fever ≥ 39C - 2 pts pharyngitis - 2 pts arthritis - 2 pts NLR ≥ 4 - 1 pt glycosyl ferritin ≤ 20% 7 pts = Dx (sens 92.5%) vs Yamaguchi(79%), Fautrel (76%) https://t.co/Amew1RHaA1 https://t.co/dnJ6zVyfOW

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Dr. John Cush RheumNow ( View Tweet)
Full read, solid review of Diagnosis and management of autoimmune hepatitis from BMJ https://t.co/9OdxHjXMKW https://t.co/1kuHPZBLSE

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Dr. John Cush RheumNow ( View Tweet)
Pregnancy & RA: metanalysis of 9 studies, 12K RA pts met vs 10 million controls. RA preg have more maternal complications (C sect OR 1.55; preeclampsia OR, 1.6; preterm OR, 1.8) & neonatal probs (low gestat wt, ICU OR 1.34, & stillbirths OR, 1.99). https://t.co/30WTMC3MKn https://t.co/VXoHesd3iT

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Dr. John Cush RheumNow ( View Tweet)
Univ of Toronto’s PsA Study looked at surgery amongst 1574 pts: 185 pts (~12%) had 379 MSK surgeries related to PsA. Signif higher rates of surgery were seen w/ #damaged joints (HR 1.03), TJC/SJC (HR 1.04), nail Dz (2.08), ^ ESR (2.37), B27+ (2.22) https://t.co/XdUJ0guwUh

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Dr. John Cush RheumNow ( View Tweet)

Frailty in Vasculitis Dr. Patricia Harkins sits down with Professor Sebastian Sattui to discuss Abstract 0444, Prevalence of Frailty and Associated Factors in Patients with Vasculitis, being presented on at the ACR22 Convergence. https://t.co/u0CZuEcyM9 https://t.co/JXEcSoHsA2

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Dr. John Cush RheumNow ( View Tweet)
New Guideline: Vaccinations OK With Few Tweaks for Rheum Patients Nearly all available vaccines can be given to people with rheumatologic diseases, according to a new, detailed guideline from the ACR. https://t.co/514mIylgzj https://t.co/9Zq9pGcujV

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Dr. John Cush RheumNow ( View Tweet)

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