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GRAPPA Recommendations for Treating Enthesitis in Psoriatic Arthritis
GRAPPA has provided new, evidence based updates to the management of enthesitis in patients with psoriatic arthritis (PsA), affecting at least 30% of PsA patients and is associated with more severe disease, x-ray damage, and poorer outcomes.
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ICYMI: GRAPPA Recommendations for Treating Enthesitis in Psoriatic Arthritis
GRAPPA has provided new, evidence based updates to the management of enthesitis in patients with psoriatic arthritis (PsA), affecting at least 30% of PsA patients and is associated with more severe disease, x-ray damage, and poorer outcomes.
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ChatGPT - A Boon or Threat to Scientific Publication?
ChatGPT is a new, artificial intelligence chatbot that has dramatically changed the digital worlds of education, research, graphic design, statistics and more.
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High- Versus Low-Dose Exercise Therapy for Knee Osteoarthritis
Exercise is known to improve function, pain and quality of life (QOL) in patients with knee osteoarthritis (KOA), but optimal amount of exercise is unknown.
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Have a rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology.
https://t.co/TampvCiCIs https://t.co/y9FDVJoEaD
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Metanalysis of Steroid Tx & metabolic events (118 studies & 17113 pts) showed an increased risk:
- hyperglycemia 10% (esp lung dz 22%)
- severe hyperglyc. 5%, HTN 6%, Wt gain 13% , hyperlipid 8%
- Incr risk of hyperglyc(OR 2), HTN (1.7), Wt gain (5.2) https://t.co/E54IB3YVfn https://t.co/CPzrgIgJ12
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Full read, very good review of steroids, HPA suppression, equivalents, use during surgery etc from J Endo Society. Notably literature supports continued daily GC in surgical patients, with a short course of perioperative IV GC https://t.co/jzNE5o0DBG https://t.co/6V8mhTOVTv
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Dr. John Cush RheumNow ( View Tweet)
About 1 mo ago we reported US drug makers would increase price of 350 drugs; now it seems US Pharma has raised list prices of 983 arthritis, cancer and otherdrugs by an average of 5.6% in Jan 2023; as industry faces new federal laws to control costs https://t.co/HkdDurbNrQ https://t.co/rEvmwACdfk
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Dr. John Cush RheumNow ( View Tweet)
Early ph II Pilot trial of 30 Systemic Sclerosis Pts using a new antifibrotic FT011 400mg vs 200mg v PBO x 12 wks showed CRISS score improved by 60% (400mg; (p=0.02 ) or 20% (200mg) at 12wks. An OL extension is planned for 9 mos @400 mg/d. https://t.co/8R51VLUbvX https://t.co/vc3JJKXfk3
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Dr. John Cush RheumNow ( View Tweet)
Novel Proteomic Biomarker Set in Osteoarthritis
NIH funded researchers have developed a set of serum proteomic biomarkers that successfully predict clinically relevant KOA progression (both structural change and joint pain) over a 2 year period.
https://t.co/4xU2bYS0xN https://t.co/Rtdr280ghe
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Dr. John Cush RheumNow ( View Tweet)
Physician Burnout Remains, Less So in Rheumatology
The 2023 Medscape Survey on Physician burnout ranks rheumatology at #10; which is down from #2 when the survey was last done in 2021.
https://t.co/IsC8TQ95RH https://t.co/BBQaSUnQoj
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Dr. John Cush RheumNow ( View Tweet)
1st there was combined Rheum-Derm or Rheum-Pulm clinics. Medscape reports new Rheum-Cardiology clinics at Cleveland Clinic, NYU, Brigham, Stanford. Useful in research, managing Rheum pts a) at hi CV risk, B) having procedures/surgery, c) risk reduction https://t.co/Y5KDv7wSho https://t.co/WjHVxOQ1xJ
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Dr. John Cush RheumNow ( View Tweet)
Join us at RheumNow Live this March!
Dr. Janet Pope ( @janetbirdnope) will be back to discuss decisive therapeutics in RA.
https://t.co/1aUe1mk4La https://t.co/R1xRMDK6MK
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Dr. John Cush RheumNow ( View Tweet)
Herpes Zoster with JAK Inhibitors
A recent review a higher HZ risk with JAKi therapy shows the HZ-risk in RA and UC to be higher than PsA when treated with usual doses of TOFA, especially those given higher TOFA doses or concomitant glucocorticoids.
https://t.co/rlYXJWONyS https://t.co/nwqbbp6Ci3
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Dr. John Cush RheumNow ( View Tweet)
Is JAKi therapy safe in RA-ILD pts? Italian retrospective study (2018-June 2022) w/ 43 RA pts & HRCT proven ILD (med age 69yrs) & Rx w/ JAKi. After 19 mos F/U, the FVC was stable in 79%, improved in 11%, & worse in 11%. DLCO & HRCT trend was similar. https://t.co/T0rP96FM0Z https://t.co/W8NFtfevQg
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Dr. John Cush RheumNow ( View Tweet)
Rretroperitoneal fibrosis Tx is fraut-steroids, tamoxifen, MMF, B cell therapy? OL trial in 8 RPF pts used steroids & mTOR inhibitor sirolimus (2mg/d x 3d; 1mg/d); 12 & 48wks - decr in fibrous tissue 50%, ESR 70%, IgG4 50% w/ normalized renal funct.
https://t.co/LbptMLCiJO
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Dr. John Cush RheumNow ( View Tweet)
Can something as simple as a cup of coffee with milk have an anti-inflammatory effect in humans?
Apparently so, according to a new study. A combination of proteins and antioxidants doubles the anti-inflammatory properties.
https://t.co/vuZwsrojwH https://t.co/NFNqHOKuOz
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Dr. John Cush RheumNow ( View Tweet)
FDA has approved the 1st BTK (Bruton’s tyrosine kinase) inhibitor (Jaypirca™ or pirtobrutinib) for adults with refractory mantle cell lymphoma. BTK inhibitors are also being developed for use in MS, RA, SLE, pemphigus & more https://t.co/599tK21H1Z https://t.co/KSqMMDWmfd
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Dr. John Cush RheumNow ( View Tweet)
US Postage, circa 1949 "The Doctor" from a painting done by Sir Luke Fildes, “The Doctor” 1891. Portrays the values of the ideal physician and the inadequacies of the medical profession. Child in a 'crisis' (forefront) and ' dawn' light represents hope. https://t.co/OaECk6MlMZ
Dr. John Cush RheumNow ( View Tweet)
Jan 2023 Medscape Physician Burnout Report: lists Rheum @ #10 (down from #2)
1 Emergency med 65%
2 Int med 60%
3 Peds 59%
4 OB & ID 58%
5 Family med 57%
6 Neuro, Anesth 55%
7 Pulm, XRay 54%
8 Onc, GI 52%
9 Surgery, Endo 51%
10 Rheum 50% https://t.co/n66oi1Ah73 https://t.co/qTF4t2NTca
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Dr. John Cush RheumNow ( View Tweet)