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Spiera et al. Sarilumab in refractory PMR (SAPHYR) - Phase 3 RCT. Significant effect of IL-6i. @RheumNow #ACR22 Abstr#1676 https://t.co/2MS441B8gU https://t.co/jBd7YJKrTs
Richard Conway RichardPAConway ( View Tweet)
#ACR highlights - #pegloticase in #gout - less reactions and more benefit w #MTX MIRROR RCT. Better than no MTX. Will change my practice - if I can access to a #peguricase, I will Rx w concomitant MTX Abst#0001 #ACR22 @RheumNow
Janet Pope Janetbirdope ( View Tweet)
Updated ACR Guidelines on Prevention and Rx of GIOP
Rx recommendations when new fractures occur after 12 months of initial OP Rx
https://t.co/TWdI728pCp
Mary Beth Humphrey #ACR22 @RheumNow https://t.co/wHANvymd5R
Links:
Dr. Antoni Chan synovialjoints ( View Tweet)
Updated ACR Guidelines on Prevention and Rx of GIOP
OP Rx in special populations
https://t.co/TWdI728XrX
Mary Beth Humphrey #ACR22 @RheumNow https://t.co/0h72a4jXmG
Links:
Dr. Antoni Chan synovialjoints ( View Tweet)
PATCH study, 👁 safety data in children 5 yrs after birth
In utero HCQ exposure does NOT:
-impact retinal morphology (OCT)
-reduce significantly retinal thickness
https://t.co/D7SgPG6PX4
Abs#1647 #ACR22 @RheumNow
Aurelie Najm AurelieRheumo ( View Tweet)
WE-CAN pragmatic RCT on community-dwelling ♂️&♀️ >/=50y w/ knee #osteoarthritis & obesity:
💠Diet + exercise = significant weight ⬇️and ☑️WOMAC pain score, WOMAC function, 6min walk distance & SF-36 HRQoL
🍽️+🚶♀️in OA? = Yes we can!
#ACR22 @RheumNow @rheumarhyme https://t.co/Ty2boH52HC
sheila RHEUMarampa ( View Tweet)
Ab1675 #ACR22 WE-CAN - Knee OA
823 randomized pts, 18 mo: Intensive Diet & Exercise (D+E)
Primary endpt: WOMAC pain - 32% reduct in pain in D+E, vs 24% (PBO)
20% more likely: clinically meaningful improve
Improved BMI, 6MW, HRQoL, activity
Pain Rx, depression: no change
@RheumNow https://t.co/Su2g4Z38FV
Eric Dein ericdeinmd ( View Tweet)
Does diet & exercise work for knee pain in #osteoarthritis? Pragmatic trial in 3 community sites. 823 RCT, 80% completed -control was education &meetings vs diet&exercise;more intense. 101kg, 77% F, age 65. Diff modest-favoured diet & exercise-works a bit #ACR22 @RheumNow #1675 https://t.co/akjEjVprJl
Janet Pope Janetbirdope ( View Tweet)
Pain in #psoriaticarthritis might not be all inflammatory..
In this study presented by Dr F Sunzini:
👉PsA pts w/⬆️FM scores had⬆️functional brain connectivity bet mid-post IC & thalamus, phgyrus & PFC
..so consider nociplastic pain too & adjust mgt
#ACR22 @RheumNow ABST#2256 https://t.co/suCAvx0pD5
sheila RHEUMarampa ( View Tweet)
Plenary session III:
Intensive diet and exercise program in overweight/obese pts with knee OA showed significant reduction in weight, pain and function, greater walk distance and quality of life.
Abs#1675 @RheumNow #ACR22 https://t.co/vstfJahLQV
Robert B Chao, MD doctorRBC ( View Tweet)
Bruce et al. Rheumatic disease onset/flare with ICI assoc good tumour response in melanoma. OR = 14.151 @RheumNow #ACR22 Abstr#1668 https://t.co/870ODwva5n https://t.co/bcneKZbeC4
Richard Conway RichardPAConway ( View Tweet)
Bass et al. Treatment ICI-arthritis. Tricky one. MTX alone assoc longer time to cancer progression and to arthritis control compared to combination with bDMARD. Thoughts @drdavidliew ? @RheumNow #ACR22 Abstr#1669 https://t.co/8KH8RZzcaZ https://t.co/DtpA8s4PLy
Richard Conway RichardPAConway ( View Tweet)
Are your SpA pts planning on conceiving? Be careful with NSAID use
French study found age and NSAID use associated with longer time-to-conception.
Factors not associated: smoking, BASDAI score, DMARD use
#ACRBest Abs#1673 @RheumNow #ACR22 https://t.co/D63XTY7IB8
Robert B Chao, MD doctorRBC ( View Tweet)
Ab1673 #ACR22: Time-to-Conception (T2C) in SpA
Prosp, observ
88F, 56 pregnancy
Subfertility in 45% F, T2C 16 mos
Risks: age, NSAID
Rx: NSAIDs (26%), steroids (9%), csDMARD (14%), biol (69%)
No control grp - Is it cause or correlate?
2020 Repro G/L rec d/c NSAID
@RheumNow #ACRBest https://t.co/e51XjhyH9u
Eric Dein ericdeinmd ( View Tweet)
☝️Treatment is the 3rd reason why we need to order a BL HRCT in pts with ILD; "We can't treat SSc-ILD if we are not able to detect SSc-ILD" - Dr. Elana Bernstein
#ACR @RheumNow #rheumatology https://t.co/ooZVSbt3Xf
sheila RHEUMarampa ( View Tweet)
Peresolimab humanized IgG1 mab
➢ stimulates PD-1 & physiological immune inhibitory pathways
➢ In RA phase 2 study, superior to placebo at Week 12 DAS28/CDAI
➢ safety events were similar between treatment groups
Emery P #L03 https://t.co/4Jd79CW5RA #ACR22 #ACRBest @RheumNow https://t.co/PSuLQgjYuz
Dr. Antoni Chan synovialjoints ( View Tweet)
BE OPTIMAL Study - Bimekizumab (IL-17A and IL-17F inhibitor) for treatment of PsA.
Similar ACR 50 (~50%) response rates of Bimekizumab, adalimumab, and placebo (switched to BKZ at wk 16).
~60% PASI100 in BKZ
#ACRBest Abs#L02 @RheumNow #ACR22 https://t.co/W2B2kyju9F
Robert B Chao, MD doctorRBC ( View Tweet)
Hamroun et al. Preconceptual NSAID use assoc impaired fertility in SpA, HR 3.01 for time-to-conception @RheumNow #ACR22 Abstr#1673 https://t.co/jresR9MfXF https://t.co/flyfJob9un
Richard Conway RichardPAConway ( View Tweet)
Congratulations @RheumNow @rheum_cat @CreakyJoints 🎉 #ACR22 https://t.co/P7iLUPnt0p
Catherine Sims, MD DrCassySims ( View Tweet)
Ab1674 #ACR22 HCQ in pregnancy is SAFE and Standard of Care!
In Utero Exposure to HCQ does NOT ass w/ ocular toxicity: OCTs 5 yrs after birth 👀
PATCH study of HCQ to reduce CHB in pregnancy
18% CHB (historical) -> 7% treated risk
OCT: retinal thickness nml at 5 yrs
@RheumNow
Eric Dein ericdeinmd ( View Tweet)