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Up-front Secukinumab in PsA?

d Richard Conway, MBBChBAO, PhD

We now have an absolute plethora of agents available for use in psoriatic arthritis (PsA). In contrast we have an almost complete lack of understanding of how best to optimise use of these agents – what is the right agent at the right time for the right patient. A study presented this week has given us some further information on the topic.

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Gender

Gender Differences in SpA

d Sheila Reyes, MD

One of the hot topics during the meeting was gender differences in SpA. Three abstracts presented addressed issues related to these differences particularly in the aspects of treatment response and disease activity.

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Is Pregnancy Truly the Solution for RA? Pregnancy is perhaps the oldest treatment in rheumatoid arthritis (RA) and has been associated with a natural improvement in disease control in 50-75% of patients. Others, however, are not as successful with unchanged disease activity or… https://t.co/MesVIUl0fC https://t.co/760i5znmeu
Dr. John Cush RheumNow ( View Tweet)
💊Dapirolizumab (DZP) is a novel CD40L inhibitor 💊Results from phase 3 trial in #SLE 💊Demonstrated improvement in disease activity & GC tapering 💊More pts on DZP achieved BICLA response vs PBO 💊DZP well tolerated AbL16 #ACR24 @RheumNow https://t.co/dtb8QFKvlN

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Mrinalini Dey DrMiniDey ( View Tweet)
Dapirolizumab pegol (DZP) a novel drug wc inhibits CD40L signalling. In the PHOENYCS GO trial, pts on DZP+SOC achieved BICLA response at wk 48 vs. DZP+PBO -observed efficacy in SRI4, SLEDAI2K, LLDAS, BILAG -reduxn in steroid dose -well tolerated @RheumNow #ACR24 abL16 #ACRBest https://t.co/5tj2uwqeUz

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sheila RHEUMarampa ( View Tweet)
Allogenic CD19 CAR-NK cells in SLE, experience w/22 pts 68% LLDAS remission, no relapse As with others, B cell reconstitution w/naive B cells & surprising safety (only 2 cases low-grade CRS) Lots of potential; still figuring out the particulars #ACR24 @RheumNow Abstr#L17 https://t.co/zLtMNrXIlX

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Mike Putman EBRheum ( View Tweet)
LEVI-04 a novel neurotropin3-i showed: -significant analgesia across all measures -improvement in functional measures and PGA for all doses in a Ph2 RCT - well tolerated Hopefully will prove to be a therapeutic option for knee #osteoarthritis in future @RheumNow #ACR24 absL15 https://t.co/kWsyyyGxyU

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sheila RHEUMarampa ( View Tweet)
Late breaking abstract L19 Study on the efficacy & safety of Emapalumab in treating Macrophage Activation Syndrome (MAS) in Still's Disease. Key findings: - 53.8% achieved complete response (CR) at Week 8; 85% at any time. - Rapid reduction in hyperinflammation biomarkers… https://t.co/VcmUdRP6PV https://t.co/r7AMt0IjYk

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Antoni Chan MD (Prof) synovialjoints ( View Tweet)
Grom et al. Emapalumab (anti-IFNg) in MAS in Stills. 39 patient pooled analysis. 54% complete response at week 8, 85% at any time. Clinically meaningful glucocorticoid reduction in 72%. @RheumNow #ACR24 Abstr#L19 https://t.co/U72KCfsUh7 https://t.co/jNxsvhseVf

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Richard Conway RichardPAConway ( View Tweet)
Sustained Complete Renal Remission ➡️v strict endpoint in #lupus #nephritis trial from 1 yr to 3yr f/u ▶️all added to #LN SoC #Voclosporin 20.1% vs #placebo 11.8% Better if 1 visit only didn’t meet endpoint ➡️ then 10% more per group ACRBest ACR24 @ACRheum @RheumNow abst1545

Janet Pope Janetbirdope ( View Tweet)

Conaghan et al. LEVI-04, neurotrophin-3 inhibitor in knee OA. 518 patients. Significant improvements in WOMAC pain and function, and PGA. So sign of any increase in rapidly progressive OA (as with NGF inhibitors) @RheumNow #ACR24 Abstr#L15 https://t.co/qud4wTAikY https://t.co/0wjjG4U4bf

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Richard Conway RichardPAConway ( View Tweet)
Late breaking abstract L16 Dapirolizumab Pegol showed significant improvement in SLE disease activity in our Phase 3 trial. Key findings: - 49.5% of patients achieved BICLA response at Week 48 vs 34.6% on placebo (p=0.0110). - 60.1% achieved SRI-4 response vs 41.1% on placebo… https://t.co/ZawdsLOxmK https://t.co/gpV3KayIW1

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Antoni Chan MD (Prof) synovialjoints ( View Tweet)
PHOENYCS GO, RCT of dapirplizumab, novel CD40Li in SLE Met primary endpoint (NNT~6 for BICLA) & numerical improvements in many other endpts 1 MI & 1 death from infection over 213 pts Encouraging for sure! Second phase 3 being launched #ACR24 @RheumNow Abstr#L16 #ACRbest https://t.co/QwDMKjhFvb

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Mike Putman EBRheum ( View Tweet)
RheumNow’s expanded coverage of the #ACR24 Annual meeting is sponsored in part by Novartis. All content is chosen by RheumNow & its faculty

Dr. John Cush RheumNow ( View Tweet)

In order to have a #DMOAD in knee #osteoarthritis ➡️ early detection may be v important Study of early pt Symptoms was done 2/3 had pain 1/2 #joint Swelling Need biomarkers & sensitive imaging in early #OA as symptoms are NOT uniform #ACR24 @RheumNow @ACRheum abst2111 https://t.co/K94m9rOjtP

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Janet Pope Janetbirdope ( View Tweet)
Pts w #osteoarthritis and T2 DM 👇 Who Have ⬆️pain Have worse control of #diabetes Even after adjusting for #BMI Chicken or egg - which comes 1st 🤷‍♀️ #ACR24 @RheumNow @ACRheum Abst#2110 https://t.co/eN2xAw0EMG

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Janet Pope Janetbirdope ( View Tweet)
Does #hand #osteoarthritis Benefit from #traction #splinting? Nope 👎 Small 2 site #RCT - not helpful I may Recommend #splinting - sometimes pts get Pain relief - in my opinion but this one didn’t help #ACR24 @RheumNow @ACRheum Abst#2108 https://t.co/K0Ud7uCb1P

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Janet Pope Janetbirdope ( View Tweet)
How long is a long acting #intra-articular #steroid #injection in #knee #osteoarthritis? #IA steroids can be q3monthly #RCT of IA #fluticasone #propionate Was superior to #placebo Seemed to last approx 24 weeks ➡️ sub analysis in moderate pain, BMI<30 #ACR24 @RheumNow #2106 https://t.co/QBFCqXd1Q8

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Janet Pope Janetbirdope ( View Tweet)
#Scleroderma #molecular #signatures in #skin predict long term outcomes 👇worst with inflammatory signature This may have clinical and trial applicability Nice work! Abst0711 #ACR24 @RheumNow @ACRheum https://t.co/3CFxu6bACu

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Janet Pope Janetbirdope ( View Tweet)
#PAH in #SSc still has a poor #prognosis 👎 Esp #ILD with PAH - a double whammy But also group 1 PAH And Some are unclassifiable ▶️also bad px Need Earlier detection More interventions ?prevention Abst#0678 #ACR24 @RheumNow @ACRheum @sclerodermaUM https://t.co/AEQsTC1pzQ

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Janet Pope Janetbirdope ( View Tweet)
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