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2022 ACR G/L for Integrative RA Intervent #ACR22
1 strong rec: consistent exercisee
27 conditional recs:
Rehab, Mediterr diet, against other diets, self-mgmt/CBT/acupunct
Conditional against electrotherapy, chiropractor
No rec for diet supplem
BMI, 🚬: no RA spec recomm
@RheumNow https://t.co/cVFr6beQuJ
Eric Dein ericdeinmd ( View Tweet)
Patel @draditipatel et al. Delay in starting ACE-I in Scleroderma Renal Crisis increased need for dialysis 75.6% vs 16.7%, p=0.023. No effect on overall survival. 5-year mortality 70%, 1 year mortality 58%. @RheumNow #ACR22 Abstr#1530 https://t.co/cdYhEtqcHT https://t.co/lDWJto1cF0
Richard Conway RichardPAConway ( View Tweet)
Mease et al. PsA - Early DMARD initiators (=<1 year following diagnosis) greater improvement in outcomes than late initiators (at least in MDA) in CorEvitas. @RheumNow #ACR22 Abstr#1493 https://t.co/oadxbG8TKS https://t.co/245xVTcKx1
Richard Conway RichardPAConway ( View Tweet)
Nabi. Biosimilar to biosimilar IFX switch in DANBIO. High retention rate - 92% in originator-experienced equiv to normal drop off at 1 year on a biologic. Lower retention 83% in originator-naive switchers = likely nocebo effect @RheumNow #ACR22 Abstr#1112 https://t.co/oa1SawWWs4 https://t.co/iU3doB9jV4
Richard Conway RichardPAConway ( View Tweet)
New biomarkers of increased disease activity in PsA?
Tissue remodeling and inflammation (neutrophil activity and fibrosis) biomarkers showed best performance in differentiating PsA w/ flares and without.
Abs#1610 @RheumNow #ACR22 https://t.co/73ta7VXgTY
Robert B Chao, MD doctorRBC ( View Tweet)
Kiltz et al. Greater efficacy of secukinumab in normal BMI than high BMI AS patients. Decremental effect with increasing BMI. @RheumNow #ACR22 Abstr#1495 https://t.co/zwEmQsJmPT https://t.co/nOW2IbTc5t
Richard Conway RichardPAConway ( View Tweet)
Dörner et al. Remibrutinib (BTKi) in pSS. + study in pSS! Improved ESSDAI (disease activity), no effect ESSPRI (PRO), trend to improve salivary flow, + effect on multiple labs. @RheumNow #ACR22 Abstr#1113 https://t.co/m2rvXbqq7b https://t.co/jQLyP66zX9
Richard Conway RichardPAConway ( View Tweet)
Benesova et al. Higher treatment response to secukinumab in both male and female AS patients when diagnosed earlier. No such effect seen in PsA patients. Emphasises need to reduce diagnostic delay in AS. @RheumNow #ACR22 Abstr#1497 https://t.co/9g2zN85a33 https://t.co/LfvQFTKr69
Richard Conway RichardPAConway ( View Tweet)
Promising results for Izokibep in PsA
Ph2 RCT meets primary endpoint at Wk 16
ACR50: 13% PBO 48% 40mg IZO 52% 80mg IZO
MDA: 5% PBO 42% 40mg 39% 80mg
Results observed as soon as wk2
No new safety signal compared to IL17Ai
https://t.co/Gilhg5k36b
Abs#1597 #ACR22 @RheumNow https://t.co/VvxSRLtkFk
Aurelie Najm AurelieRheumo ( View Tweet)
Protective effect of #allopurinol in gout
Dose dependent reduction in risk of acute coronary syndrome in incident #Gout
#ACR22 @RheumNow abst#1582 https://t.co/PrEtRwvLvm
Bella Mehta bella_mehta ( View Tweet)
Abs 1187 apremilast may have beneficial effects on cardiometabolic measures including reductions in HbA1c in severely obese patients and reductions in weight and dz activity improvements in PsO/ PsA outcomes across all BMI categories. #ACR22 @RheumNow https://t.co/fCdJxz2IDk https://t.co/mLnwKQs539
Dr. Rachel Tate uptoTate ( View Tweet)
Enjoy the post-session adult beverage #ACR22 and #rheumtwitter but, choose wisely as Abs 1206 finds beer consumption was consistently assoc'd w/ higher serum urate levels, whereas sake showed only modest associations in both males and females. @RheumNow https://t.co/ETtU31iTZ0 https://t.co/keG5IN7LbC
Dr. Rachel Tate uptoTate ( View Tweet)
Catch our daily recap LIVE at 5pm ET. #ACR22 https://t.co/OpPcGhnWJ1
Dr. John Cush RheumNow ( View Tweet)
Dr. @Drbeckyg reminds us that self-reported, RA patient completed joint counts are good for tender and ok for swollen. Check out her videos for teaching joint counts to your patients - all under 8 minutes in total. #ACR22 @RheumNow https://t.co/E2wBsNFS12
Dr. Rachel Tate uptoTate ( View Tweet)
Makol @AshimaMakol et al. Digital ischaemia 79% SSc patients. Higher risk - digital occlusive arterial disease on laser doppler flowmetry Macrovascular disease on US, ILD, calcinosis, pericardial effusion. @RheumNow #ACR22 Abstr#1518 https://t.co/DJTtCVD0Oe https://t.co/9i4Vivir8q
Richard Conway RichardPAConway ( View Tweet)
Chen et al. Tofacitinib in new-onset PMR. Tofa (No GC!) vs standard GC. Equally effective! @RheumNow #ACR22 Abstr#1107 #ACRbest https://t.co/w3WJ8YZsyz https://t.co/qmt1RUAAGB
Richard Conway RichardPAConway ( View Tweet)
Pike M Abstract 1113. Remibrutinib (LOU064) in Sjögren’s Syndrome: Safety and Efficacy Results from a 24‑Week Placebo-controlled Proof-of-Concept Study #ACRBest #ACR22 @RheumNow
Dr. Antoni Chan synovialjoints ( View Tweet)
"Telemedicine is not inferior to F2F visits in Rheumatology!" Dr. @RheumNow. While this may be true, it takes patient education and setting expectations about the visit (no driving during appointment!) #ACR22 @KDAO2011
Dr. Rachel Tate uptoTate ( View Tweet)
Torgutalp et al. Higher NSAID intake associated reduced spinal progression in AxSpA esp. r-AxSpA. Cox-2 may have greater effect than other NSAIDs. @RheumNow #ACR22 Abstr#1492 https://t.co/bGH6bBo7AD https://t.co/XBFV410Y2p
Richard Conway RichardPAConway ( View Tweet)
Baker et al, Corevitas registry in 7000+ RA pts
Pts w/ moderate pain HR 1.37
Pts w/ severe pain HR 1.42
more likely to switch to diff MOA b/tsDMARD
Adjusted for confounders incl DA
Time we address pain separately to spare MAOs in a lifelong disease!
Abs#1590 #ACR22 @Rheumnow https://t.co/RP8Rb6bp9m
Aurelie Najm AurelieRheumo ( View Tweet)