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EULAR 2023 – Day 1 Report
EULAR 2023 launched today to crowds of attendees. The opening Plenary session and presidential address by Dr.
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Promising new therapies in SLE
The pharmacology treatment in SLE is a rapidly expanding field of research that provides excitement and optimism to both the patients and the clinicians. We now have three licensed targeted therapies (belimumab and voclosporin in active lupus nephritis and anifrolumab in non-renal SLE) over the last 3 years compared to one therapy (belimumab in non-renal SLE) in the previous 50 years. What are other promising therapies on the horizon?
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Get Un ‘DRESSED’? Use of #etanercept or #adalimumab for #rheumatoidarthritis. #RCT of dose optimization-observational f/u over 10 yrs with attempts to lower and even d/c Rx in #RA You CAN lower dose in many Pts & even d/c Rx and recapture. X-rays OK @RheumNow #EULAR2023 #OP0131 https://t.co/PGK5SQJ1WU
Janet Pope Janetbirdope ( View Tweet)
As Jack himself pointed out - we’re looking at patients without loads of inflammation. For me, to get anything out of this population is very interesting. Adding this to ARIAA, it does make us think about which pre-RA might benefit from abatacept, and how.
#EULAR2023 @RheumNow https://t.co/UKHfc1X8QM
David Liew drdavidliew ( View Tweet)
@RheumNow Safety is pretty good too - this is abatacept we are talking about here. Cost is a different question, as is the pharmacoeconomics, but at least it’s safe. One other thing about the study ⬇️ #EULAR2023
@RheumNow https://t.co/H3AdBsK8t9
David Liew drdavidliew ( View Tweet)
What’s more - if you have arthralgias and more autoantibodies than just ACPA IgG, then maybe abatacept might actually make a substantial difference. There is prob a population in whom abatacept substantially prevents RA developing.
Is it safe? ⬇️
APIPPRA #EULAR2023 @RheumNow https://t.co/94Y7HrBuEp
David Liew drdavidliew ( View Tweet)
Well certainly, despite the absence of synovitis, these pre-RA patients felt better on their 12m of abatacept. They could do more and hurt less.
That does count for something for many patients.
But wait, there’s more ⬇️
#EULAR2023 @RheumNow https://t.co/3naNdWGMuX
David Liew drdavidliew ( View Tweet)
Abatacept for 12m in ACPA pos arthralgias probably doesn’t impact RA progression that much once the abatacept stops…
but are there other reasons you might want to give it? Read on in the next tweet⬇️
APIPPRA study #EULAR2023 OP0130 @RheumNow https://t.co/68CViUeWHy
David Liew drdavidliew ( View Tweet)
How much MTX do we need with adalimumab in RA? Can blood concentrations help?
MTX RBC polygluts:
- don’t seem to match to efficacy
- do seem match to safety, a bit
(no ADAb data here)
*One day* we’ll get better at what MTX dose is needed with TNFi #EULAR2023 OP0128 @RheumNow https://t.co/OGM3hxr4fG
David Liew drdavidliew ( View Tweet)
#EULAR2023 #POS0618 This is cool! Researchers from Switzerland are developing new Quantitative Radiomic Risk Score (from HRCT) to stratify response to Anti-Fibrotic in #ILD. Data presented in pre-clinical study & paralleled molecular effects. Human study is in progress @RheumNow https://t.co/qAsWew4FEO
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Is Interferon Type1 Impt in #scleroderma? #EULAR2023 OP#0114 Interferon accelerated skin fibrosis in mouse model- 61 pts 1/3 dcSSc, 2/3 lcSSc had markers of INF-1 in blood vessels &skin - more in #diffuse #SSc ?Rx opportunity w available drugs? RCT needed @RheumNow @eular_org https://t.co/vZWjSY8jKg
Janet Pope Janetbirdope ( View Tweet)
What would you do? A middle aged woman has pain and impaired hand function with her PIP&DIP erosive hand #osteoarthritis? Exam - jts are tender w soft tissue swelling? #NSAIDs, #denosumab, #methotrexate? 🤷♀️ A +RCT of #MTX in #erosive #hand #OA at #EULAR2023 @RheumNow @eular_org https://t.co/7rp3nReTPd
Janet Pope Janetbirdope ( View Tweet)
Are we going to treat hands OA with MTX?
Moderate effect on VAS pain at 6 and 12 months in a small RCT vs. PBO in hands OA WITH MRI detected synovitis.
Thoughts
1) Is it really OA?
2) Benefit Risk balance remains debatable
@RheumNow OP0070 #EULAR23 https://t.co/WLlX48NtGT
Aurelie Najm AurelieRheumo ( View Tweet)
#EULAR2023 OP0083-HPR Stretch & Strength training is key! An RCT in Brazil shows: Pilates x 3/week is more effective in reducing pain, HRQoL, psychological effects & analgaesic consumption VS Aerobic walking on treadmill x 3/week for 12 weeks in women with Fibromyalgia @RheumNow https://t.co/CzIH9Xd8Ku
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
An interesting biomarker in #sJIA- helps differentiate it from other diseases, including infections and other inflammatory diseases! - kids with fever! serum calprotectin (MRP8/14) particle enhanced immuno-turbidimeteic assay (sCAL Turbi). 650 pts @rheumnow
#EULAR2023 abst#OP0034
Bella Mehta bella_mehta ( View Tweet)
#CPPD and #cervical involvement. Several clinical presentations
A-asymptomatic deposition
B-crowned dens syndrome
C-retro-odontoid pseudotumor
D-inflammatory discitis
Good teaching points in the supplements! @RheumNow #EULAR2023 Abst#AB1859 https://t.co/LJe7Gk1oZX
Bella Mehta bella_mehta ( View Tweet)
Remember to discuss bone density in your pts with #gout! Bone mineral density was significantly lower in pts with hyperuricemia, more so in males and elderly. Large cohort wirh 9017 pts from China! @EULAR2023 @rheumnow abst#AB1639 https://t.co/BGscJxMZno
Bella Mehta bella_mehta ( View Tweet)
Gut microbiome studies are implicated in all disease we study! 5 gut microbiota are suggested to have a causal relationship in #gout.
68k controls and 2k gout pts.
Can experts comment if it's just data mining or discovery? #EULAR2023 @rheumnow abst#ab1237 https://t.co/d1AkDPG8QR
Bella Mehta bella_mehta ( View Tweet)
#EULAR2023 #OP0046 With more effective therapies in #lupus, we should aim for bare minimum/cessation of steroid. A study using French database showed:
>12% were on =>5mg Pred/d, this associated with comorbidities & increased costs
14% on high dose Pred weren’t on HCQ
@RheumNow https://t.co/x99Jt9yf1g
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
#EULAR2023 #OP0007 What are the recent trends of autoimmune disease (AID)? A database study (22m) in UK showed:
- 1 in 10 people had AID in the last 20yrs
- socioeconomic, seasonal & regional disparities cd influence pathogenesis
- CTD (SLE,pSS,SSc) tended to co-occur @RheumNow https://t.co/3DDPR2K5NC
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
