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Izokibep, a new IL-17Ai, demonstrated efficacy in treatment of psoriatic arthritis in a phase 2 study with a safety profile similar to other IL-17i.
Abs#1597 @RheumNow #ACR22 https://t.co/3LA9u8NsC4
Robert B Chao, MD doctorRBC ( View Tweet)
#ACR22 Abstr#0957 Do women with Anti-Ro/La+ get 1st screening for congenital heart block via foetal echo in time (16-18 wks)? A cohort study in 44 pregnancies found only 32% had =<18wks. 5 CHB detected (3 in 1st screening which was >19wks. This needs to improve @RheumNow https://t.co/dqJCCSwGLx
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Increasing fracture incidence rates for both AS and comparator groups. Increased in the TNFi era (2004-2021) relative to the pre-TNFi era (2000-2003). The ratio (AS/comparators) appear stable over the past 2 decades
Merjanah S Abs1911 https://t.co/lLtW4eh0nm #ACR22 @RheumNow https://t.co/1Nr6ru1vPv
Dr. Antoni Chan synovialjoints ( View Tweet)
Tune in to Twitter, Facebook or LinkedIn daily at 5pm ET. Catch our daily recap LIVE! #ACR22 https://t.co/fgwqIjuXJ4
Dr. John Cush RheumNow ( View Tweet)
Lifestyle modifications can affect tx response with TNFi in axSpA!
Accdg to this study fr Prof GJones, ✳️Smokers, overwt & obese pts are ⬇️ likely to achieve treatment response to TNFi vs. nonsmokers & normal wt pts
Smoking cessation, wt mgt is key!
#ACR22 @RheumNow ABST#1510 https://t.co/PBFcj6zKVD
sheila RHEUMarampa ( View Tweet)
De Craemer et al. Local vs Central reading of images. Rheumatologists overcall sacroiliitis on both plain films and MRI in ?AxSpA . ? some of this out of a desire to try something to help someone who is suffering @RheumNow #ACR22 Abstr#1255 https://t.co/j89E0sUPmN https://t.co/Ez5ldSSQJl
Richard Conway RichardPAConway ( View Tweet)
Ramahi @sclerodermaUM et al Risk factors for ILD decline in SSc. Anti-Topoisomerase I only identified factor in multivariable model. @RheumNow #ACR22 Abstr#1524 https://t.co/lc2BPjgqiC https://t.co/qx3M6dfd3w
Richard Conway RichardPAConway ( View Tweet)
Plenary:
Tyrosine kinase 2 (TYK2)
◦ Mediates signaling of Type I IFNs, IL-23, and IL-12
◦ Key cytokines involved in lupus pathogenesis
◦ Deucravacitinib oral TYK2 inhibitor
◦ Phase 2 RCT in SLE showed efficacy
Pike M Abs1117 https://t.co/eJhNsM02Vl #ACR22 @RheumNow https://t.co/C6JQqR1DLj
Dr. Antoni Chan synovialjoints ( View Tweet)
Doyen et al. FIND-RA study. RA for >1<10 years. RA-ILD 12%, air trapping 58%, rheumatoid nodules 11%. @RheumNow #ACR22 Abstr#1393 https://t.co/Sy1qwZJq5E https://t.co/ww8HgHT32E
Richard Conway RichardPAConway ( View Tweet)
There is an association between the severity of skin and joint or axial disease, both at baseline and longitudinally, in pts presenting w/in 12 months of diagnosis of PsA. Abs 1511 #ACR22 @RheumNow https://t.co/PcVn6dITqU https://t.co/qxn3LBOW8d
Dr. Rachel Tate uptoTate ( View Tweet)
Sanchez Martin et al. Assessing effect tocilizumab by PET in GCA. Vascular involvement not generally fully controlled by tocilizumab. Not sure how PET was scored here. @RheumNow #ACR22 Abstr#1257 https://t.co/cGEoScnPb3 https://t.co/W0yYMPMjni
Richard Conway RichardPAConway ( View Tweet)
Yen et al. Taiwanese study of risk of MACE in SSc. No difference in MACE IRR 1.15 (95%CI 0.87–1.52) or stroke IRR 0.89 (95%CI 0.61-1.29), increase in MI IRR 1.76 (95%CI 1.08-2.86) @RheumNow #ACR22 Abstr#1191 https://t.co/3BiTLafGmk https://t.co/IManEvAh47
Richard Conway RichardPAConway ( View Tweet)
HZ risk after each (1 of 3) BNT162b2 mRNA vaccination doses was not increased in PsA and AS patients compared to a similar time period two years prior . The risk of HZ increased with age. Abs 1489 #ACR22 @RheumNow https://t.co/YmcqDNoxya
Dr. Rachel Tate uptoTate ( View Tweet)
I find this incredibly encouraging
SAPHYR subanalysis:
refractory PMR
sarilumab (w 14w PNL taper) vs placebo (w 52w taper)
?no Sx
Benefit kicks on after PNL taper stops, out to 52w
Reality in practice: bit more PNL prob gives excellent Sx outcomes
ABST1543 #ACR22 @RheumNow https://t.co/kGBZyULZeU
David Liew drdavidliew ( View Tweet)
Even a 6 month delay in PsA diagnosis can lead to worse PROs on quality of life!
Likelihood of depression increased
Pts with PsA dx in <6 months reported better outcomes
Abs#1507 @RheumNow #ACR22 https://t.co/igCiH22CWi
Robert B Chao, MD doctorRBC ( View Tweet)
Stop MTX and increase folic acid to 5 mg/day for pts who find themselves with an unintentional #pregnancy. -@CuoghiE #ACR22 @rheumnow https://t.co/uChPU6zrwv
TheDaoIndex KDAO2011 ( View Tweet)
GUS (compared to RIS) uniquely binds both CD64+ myeloid cells and IL-23. CD64+ mononuclear phagocytes are enriched in the psoriatic skin and serve as the dominant IL-23 source. Does this lead to a change in clinical response? Abs 1487 #ACR22 @RheumNow https://t.co/P512bxSxRn
Dr. Rachel Tate uptoTate ( View Tweet)
Aim for drug free remission in early RA? After 1 yr remission Pts randomized to stop Rx vs 1/2 dose. More flares if no Rx. For 1/2 dose if 2 yrs remission randomize to stop or stay at 1/2 dose. 2X more flares if d/c Rx. Abst2013 Arctic rewind #ACR22 @rheumnow #ACRBest Relevant ? https://t.co/nfQPExhbYj
Janet Pope Janetbirdope ( View Tweet)
Once again, high BMI and smoking associated with substantial decrease in TNFi response for treatment of axSpA.
Easier said than done however. How are you helping pts lose weight or stop smoking?
Abs#1510 @RheumNow #ACR22 https://t.co/ircLkuXhCs
Robert B Chao, MD doctorRBC ( View Tweet)
Fulvio et al. Labial gland US to identify lymphoma in Sjogrens. OMERACT score of 3 in 100% of lymphoma and 35% non-lymphoma @RheumNow #ACR22 Abstr#1254 https://t.co/aspctOfGp8 https://t.co/CLhN2PTvaS
Richard Conway RichardPAConway ( View Tweet)