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HZ risk after each (1 of 3) BNT162b2 mRNA vaccination doses was not increased in PsA and AS patients compared to a similar time period two years prior . The risk of HZ increased with age. Abs 1489 #ACR22 @RheumNow https://t.co/YmcqDNoxya
Dr. Rachel Tate uptoTate ( View Tweet)
I find this incredibly encouraging
SAPHYR subanalysis:
refractory PMR
sarilumab (w 14w PNL taper) vs placebo (w 52w taper)
?no Sx
Benefit kicks on after PNL taper stops, out to 52w
Reality in practice: bit more PNL prob gives excellent Sx outcomes
ABST1543 #ACR22 @RheumNow https://t.co/kGBZyULZeU
David Liew drdavidliew ( View Tweet)
Even a 6 month delay in PsA diagnosis can lead to worse PROs on quality of life!
Likelihood of depression increased
Pts with PsA dx in <6 months reported better outcomes
Abs#1507 @RheumNow #ACR22 https://t.co/igCiH22CWi
Robert B Chao, MD doctorRBC ( View Tweet)
Stop MTX and increase folic acid to 5 mg/day for pts who find themselves with an unintentional #pregnancy. -@CuoghiE #ACR22 @rheumnow https://t.co/uChPU6zrwv
TheDaoIndex KDAO2011 ( View Tweet)
GUS (compared to RIS) uniquely binds both CD64+ myeloid cells and IL-23. CD64+ mononuclear phagocytes are enriched in the psoriatic skin and serve as the dominant IL-23 source. Does this lead to a change in clinical response? Abs 1487 #ACR22 @RheumNow https://t.co/P512bxSxRn
Dr. Rachel Tate uptoTate ( View Tweet)
Aim for drug free remission in early RA? After 1 yr remission Pts randomized to stop Rx vs 1/2 dose. More flares if no Rx. For 1/2 dose if 2 yrs remission randomize to stop or stay at 1/2 dose. 2X more flares if d/c Rx. Abst2013 Arctic rewind #ACR22 @rheumnow #ACRBest Relevant ? https://t.co/nfQPExhbYj
Janet Pope Janetbirdope ( View Tweet)
Once again, high BMI and smoking associated with substantial decrease in TNFi response for treatment of axSpA.
Easier said than done however. How are you helping pts lose weight or stop smoking?
Abs#1510 @RheumNow #ACR22 https://t.co/ircLkuXhCs
Robert B Chao, MD doctorRBC ( View Tweet)
Fulvio et al. Labial gland US to identify lymphoma in Sjogrens. OMERACT score of 3 in 100% of lymphoma and 35% non-lymphoma @RheumNow #ACR22 Abstr#1254 https://t.co/aspctOfGp8 https://t.co/CLhN2PTvaS
Richard Conway RichardPAConway ( View Tweet)
‼️FAP (fibroblast activation protein)
PET-CT in PsA‼️
⚡️synovial and entheseal accum in PsA v HC
⚡️correlation of uptake with pain scores
⚡️IL-17A ⬇️ FAP, with arrest joint damage
⚡️persistent FAP - ⬆️ prog joint damage
❓new T2T in PsA❓
#ACR22 @RheumNow Abst#1602
Patricia Harkins DrTrishHarkins ( View Tweet)
Gut microbiota of axSpA pts who underwent bDMARD tx for one year more closely resembled controls. Unique enrichment of Collinsella in axSpA patients remained stable across time & tx, suggesting it may be a disease biomarker. Abs 1162 #ACR22 @RheumNow https://t.co/SjwORWp6IU https://t.co/rLlu4jGCfd
Dr. Rachel Tate uptoTate ( View Tweet)
How many rheumatologists are managing psoriasis themselves? Or dermatologists managing arthritis themselves?
Survey shows <50% rheum collaborate with derm
Need updated EMRs and additional education
Abs#1502 @RheumNow #ACR22 https://t.co/1okhxFAbUS
Robert B Chao, MD doctorRBC ( View Tweet)
⚡️PRESTO⚡️
📈PsA prediction tool in psoriasis
Risk of PsA at 1yr ⬆️:
👉younger
👉male
👉FHx Psoriasis
👉back stiffness
👉stiffness level
👉nail pitting
👉biologic use
👉⬆️ pain and global health
(AUC 72.3,95%CI 65.5,79.1)
#ACR22 @RheumNow Abst#1612
Patricia Harkins DrTrishHarkins ( View Tweet)
Plenary:
Real-world observational study >1500 pts with IA, 1 year retention infliximab biosimilar CT-P13 to GP1111 switch was high. Retention was higher in originator-experienced (92vs83%) & low disease activity
Nabi H, DANBIO Abs1112 https://t.co/z84AMUS3GK #ACR22 @RheumNow https://t.co/SgGhd33Esl
Dr. Antoni Chan synovialjoints ( View Tweet)
Plenary:
Remibrutinib (LOU064) a BTK inhibitor in Sjogren’s
◦ Favourable safety profile
◦ Well-tolerated over 24 Wks
◦ Improved ESSDAI, salivary flow, Igs
◦ May be first effective oral disease-modifying therapy for SS
Dorner T Abs1113 https://t.co/FkgJpwKAJL #ACR22 @RheumNow https://t.co/znxMc27EBI
Dr. Antoni Chan synovialjoints ( View Tweet)
Frailty in Vasculitis
Dr. Patricia Harkins sits down with Professor Sebastian Sattui to discuss Abstract 0444, Prevalence of Frailty and Associated Factors in Patients with Vasculitis, being presented on Saturday at #ACR22 Convergence.
https://t.co/aMpcBhT5yE https://t.co/rPgA19dT0W
Links:
Dr. John Cush RheumNow ( View Tweet)
Does MTX dose matter for COVID mRNA vaccine immunogenicity in RA pts?
Single-center (n=126) with one MTX dose WH post-each vaccine
Similar humoral response
Big error bars suggest other factors more important
ABST0913 #ACR22 @RheumNow
(not pretty graphs but data interesting!) https://t.co/FFfTWiNjUY
David Liew drdavidliew ( View Tweet)
Henry @EBRheum et al. Less than 1 in 6 recommendations from ACR/EULAR informed by comparative effectiveness RCT. Many receive strong recommendation despite low/very low LOE. @RheumNow #ACR22 Abstr#1284 https://t.co/1MUM8qiwDl https://t.co/KJcf7rBQAU
Richard Conway RichardPAConway ( View Tweet)
GM-CSF inc'd in active AS pts, particularly in younger ages, and strongly correlates with disease activity, but not with disease duration. TNFi tx does not affect GM-SCF levels, despite improving disease activity. Abs 1156 #ACR22 @RheumNow https://t.co/ndhBGbPsCw
Dr. Rachel Tate uptoTate ( View Tweet)
Don't forget the power of NSAIDs! (esp COX2i)
10 year study from Germany.
NSAID intake associated with lower radiographic progression in axSpA patients (esp r-axSpA)
COX2i may have stronger effect
#ACRBest #ACR22 @RheumNow Abs#1492 https://t.co/vPIaCahmiW
Robert B Chao, MD doctorRBC ( View Tweet)
Prevalence of uveitis in patients with PsA was about 5%. Uveitis rate decreased w/ anti-TNFα monoclonal antibodies and increased w/ ETN and SECU. Abs 1159 #ACR22 @RheumNow https://t.co/BtHMQ6apNI https://t.co/uZEYVQdiOU
Dr. Rachel Tate uptoTate ( View Tweet)