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#abst1012 #acr22 @rheumnow CASIPSA Study of SI CT in 48 PsA pts vs 48 controls. Disease duration 22.87 ± 14.95 y, 43.48 %HLA-B27+. higher prevalences of erosion in PsA (18%) preferentially located on the anterior and middle regions of the SIJs https://t.co/4dtJNCKf4I
Olga Petryna DrPetryna ( View Tweet)
axPsA and AS adult pts exhibit different genetic risk factors & serum IL-17 levels. GUS demonstrated significant pharmacodynamic effects and clinical improvement in axPsA and non-axPsA pts. Abs 1038 #ACR22 @RheumNow https://t.co/9Rjw7usO8J
Dr. Rachel Tate uptoTate ( View Tweet)
Updates on Reproductive Health in Women with SLE
https://t.co/E09cvQbVoD
#ACR22 https://t.co/Ausa6ELoHe
Links:
Dr. John Cush RheumNow ( View Tweet)
Dallas Heart Study: at least 1 aPL detected in 15% of adults from the general population. IgA isotypes of aCL & aβ2GPI independently assoc'd w/ future ASCVD events, and aβ2GPI IgA demonstrated increased risk of atherothrombosis. Abs 0681 #ACR22 @RheumNow https://t.co/m9XUTz2S5e https://t.co/vCXLJdBg70
Dr. Rachel Tate uptoTate ( View Tweet)
We know depression, anxiety are issues for many RA pts. Are we making the diagnosis more?
Olmsted County data:
depression similar over time
anxiety 3x more common in 2005-2014 vs 1985-1994 (adj age/sex +/- others)
How do we address this?
ABST0886 @MayoClinic #ACR22 @RheumNow https://t.co/tzMEE24FZo
David Liew drdavidliew ( View Tweet)
Molina et al. Dupilumab (IL4/IL13 mab) in refractory EGPA. Complete response 49%, partial 43%. But flares in 27%. Dupilumab-induced eosinophilia in 57%. @RheumNow #ACR22 Abstr#1074 https://t.co/cziyHNPN3j https://t.co/h7gWAShQeL
Richard Conway RichardPAConway ( View Tweet)
Zuo @jasonsknight et al. Dallas Heart Study. aPL and incident CV events. IgA isotypes of aCLand aβ2GPI were independently associated with future ASCVD events. @rheumnow #ACR22 Abstr#0681 https://t.co/C7O4rnFZCG https://t.co/1H7uiPUwuv
Richard Conway RichardPAConway ( View Tweet)
Abs 0674 finds that HIT is rare among hospitalized APS and SLE patients with aPL and that anti-PF4 antibodies are often inappropriately tested in this population. #ACR22 @RheumNow https://t.co/hFZzpuEkDG https://t.co/hyUYVZLUM4
Dr. Rachel Tate uptoTate ( View Tweet)
🔥 VEXAS + the 🫁 🔥
🔑 Points ~
🫁 involvement common
👉cough + dyspnea
🌬PFTS often normal
🩻 CXR useful but HRCT superior
🩻ground glass opacity commonest finding
💊 good response GC
🔥ignite session🔥
#ACR22
Abst# 1569 @RheumNow
Patricia Harkins DrTrishHarkins ( View Tweet)
Abs 0345 finds association between cumulated HCQ and development of cardiac abnormalities. We need further data to determine clinical association. #ACR22 @RheumNow https://t.co/WmixbFIlfd https://t.co/2Ejwkeu1Az
Dr. Rachel Tate uptoTate ( View Tweet)
In the absence of other high risk factor for thrombosis, Thrombocytopenia (ITP) could be an independent and long-lasting clinical phenotype for aPLs carriers. Abs 0672 #ACR22 @RheumNow https://t.co/LmlruGqkEJ https://t.co/MaIHS0QWN0
Dr. Rachel Tate uptoTate ( View Tweet)
Sometimes we guess how RA pts will be, before they come in.
machine learning to predict RA dx activity:
RISE registry (n=39,155)
inputs: prev CDAI, demo, smoking/obesity, SES
v good performance
Past performance does predict future outcomes, sometimes!
ABST0905 #ACR22 @RheumNow https://t.co/Ir1YG1cqlD
David Liew drdavidliew ( View Tweet)
Kajiyama et al. JAKi counteract cellular toxicity of HCQ in vitro. Could they prevent HCQ-retinopathy? @rheumnow #ACR22 Abstr#0653 https://t.co/c0a4OYCzw5 https://t.co/X7pFM7j1R4
Richard Conway RichardPAConway ( View Tweet)
RheumNow’s expanded coverage of the #ACR22 meeting is sponsored in part by Bristol-Myers Squibb. All content chosen by RheumNow & its Faculty
Dr. John Cush RheumNow ( View Tweet)
Park et al. Risk-benefit of PJP propylaxis in rituximab treated patients. NNH 86 . NNT - all RTX 146, RTX+high dose steroid 21. This mirrors my practice @RheumNow #ACR22 Abstr#0720 https://t.co/JPtPCqah9R https://t.co/bonRzWFbVw
Richard Conway RichardPAConway ( View Tweet)
Kaneko et al. Tocilizumab leads to significantly lower steroid doses in Adult onset Stills Disease @RheumNow #ACR22 Abstr#0826 https://t.co/jc1S6sdfkm https://t.co/z0cHB4wYu6
Richard Conway RichardPAConway ( View Tweet)
What neonatal factors could affect development into axSpA? Turns out antibiotic exposure (6.2x more likely).
Mode of delivery, early diet (milk vs. formula), maternal smoking (!!) did not show association.
@RheumNow #ACR22 Abs#0868
#ACRBest https://t.co/roCAj5YsCt
Robert B Chao, MD doctorRBC ( View Tweet)
In non-renal SLE, BEL associated w/ a lower risk of severe infection and hospitalizations due to severe infection compared to MTX, AZA, MMF. Abs 0349 #ACR22 @RheumNow https://t.co/0EBpCMPOqF https://t.co/vdxKVJSaZA
Dr. Rachel Tate uptoTate ( View Tweet)
Isenberg et al. Atacicept 150mg in SLE. Reduced flare 36% vs 53%, delayed time to first flare, stabalised renal function (vs decline in PBO), less steroid increase (14% vs 36%), UPCR declined (vs increase in PBO) @RheumNow #ACR22 Abstr#1001 https://t.co/FRWcTAgCrn https://t.co/Amkg84OX2x
Richard Conway RichardPAConway ( View Tweet)
🔥Ignite Talk 10:20AM South Philly Stage🔥 abstract #0946
SLE, birth control, & pregnancy planning
🔥30% of women used no birth control despite only 17% voicing interest in pregnancy
🔥More 1/2 of women interested in pregnancy were not medically ready
#ACR22 @RheumNow
Catherine Sims, MD DrCassySims ( View Tweet)