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ACR 2022 - Day 1 Report
The masses have returned to ACR22, a live, face-to-face, and virtual, meeting that began Saturday in Philadelphia. There were hassles and glitches, yet the education and sessions were as you’d expect with many good presentations worth recapping.
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SLE, Sex and STDs
Once in a while, I find an abstract at the ACR meeting that can potentially save lives and be implemented in practice now.
In Abstract #0939, Dr. J Patricia Dhar and colleagues shared data from a pilot study examining a new method to monitor cervical health in African American Women with Systemic Lupus Erythematosus (SLE) using a self-sampling brush to assess cervical cytology and human papilloma virus infection.
TNFi cycling in axSpA: Results from CorEVITAS Registy study
Data presented at ACR22 shows that cycling through TNFi in axSpA patients with primary lack of efficacy with first line TNFi has limited additional benefit in controlling disease.
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🔥ignite session🔥
❓Vessel wall MRI superior to TA-US in c-GCA❓
🔥In c-GCA vessel wall MRI examines beyond the temporal arteries -
✅more 🧠 cranial arteries, including occipital arteries and the all important 👁 orbital structures
Abst#0473
#ACR22 @RheumNow https://t.co/z8hYmqc95I
Patricia Harkins DrTrishHarkins ( View Tweet)
Carter et al. Case series showing rapid effect of anifrolumab in refractory discoid lupus and SCLE. @RheumNow #ACR22 Abstr#0974 https://t.co/Od1PXzJKQh https://t.co/Hk8mrblGMX
Richard Conway RichardPAConway ( View Tweet)
Ab2126 #ACR22 Risankizumab on Enthesitis/Dactylitis
KEEPsAKE 1&2 - RZB v PBO
1407 pts -baseline 63% enth, 28% dact, 20% both
Wk 24: 14% decr. enthesitis, 17% decr dact, 13% decr both
Mean time to resolution decreased
Results maintained through wk 52
@RheumNow https://t.co/RBubeuJoh8
Eric Dein ericdeinmd ( View Tweet)
Frey @CaoilfhionnMD @JuliePaikMD et al. Increasing duration of hold of MMF (esp >=10 days) increased response to SARS-CoV-2 vaccine. No difference in disease flare rates. @RheumNow #ACR22 Abstr#0797 https://t.co/5nxo2nLg80 https://t.co/sx1Roxngx9
Richard Conway RichardPAConway ( View Tweet)
In this prospective cohort study by Dr Jacquez, there was a statistically significant inverse assoc bet. average yearly HCQ dose and overall damage accrual 👇
Reassuring data.
☝️HCQ consistently proves to be a beneficial drug for #lupus
#ACR22 @Rheumnow ABST#0982 @rheumarhyme https://t.co/nWHS9JtEsH
sheila RHEUMarampa ( View Tweet)
Pedersen @EBRheum et al. 203 RCTs, 35 (17.2%) remained unpublished more than 30 months after completion. Cited reasons: ongoing preparation/review of paper (50%), sponsor/funder problems (40%), unimportant/negative result (20%).@RheumNow #ACR22 Abstr#0827 https://t.co/V2a48iiAcn https://t.co/FLqQhjvlOx
Richard Conway RichardPAConway ( View Tweet)
#ACR22 Abstr#0825 Can we identify predictors of deaths in patients presenting with Macrophage Activation Syndrome? A cohort study (N=43) reported MAS was mostly secondary to disease. 10/43 died. Super high Ferritin and raised Ferritin/CRP ratio were assoc with deaths @RheumNow https://t.co/JCH30pi4Vf
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Boekel et al. Omicron variant assoc lower risk of severe COVID-19 in rheumatic disease than prior variants EXCEPT rituximab treated patients. @RheumNow #ACR22 Abstr#0705 https://t.co/57Boj4SEt5 https://t.co/d2NoX83y5l
Richard Conway RichardPAConway ( View Tweet)
Mendel et al. Use of TMP-SMX prophylaxis in GPA from MarketScan and Medicaid. Used in <25% treated with RTX!? Female sex negatively assoc (OR 0.61)!? Steroid use in month prior associated (OR 4.31) @RheumNow #ACR22 Abstr#1071 https://t.co/56a0nHR8o4 https://t.co/5LygdFMrss
Richard Conway RichardPAConway ( View Tweet)
Kifayat et al. Response to Shingrix in rheumatic disease patients. 3/3 PsA, 5/6 SLE, 2/14 RA pts reached protective level of 150U/ml. IgG titres and SI are 3x lower compared to non-rheumatic patients. @RheumNow #ACR22 Abstr#0800 https://t.co/Gm7ldxK5xd https://t.co/BlHuU2Jxk2
Richard Conway RichardPAConway ( View Tweet)
I was schooled for exams, testing fine motor function with a buttonhole: felt contrived.
Imagine an electrical glove for RA pts, doing functional assessment properly
Italian study: engineered glove data + HAQ correlates with DAS28
Consistent/scalable!
ABST0904 #ACR22 @RheumNow https://t.co/4ZR0An5N9j
David Liew drdavidliew ( View Tweet)
Martínez-López et al. Higher rates of elevated transaminases with DMARD in those who previously had abnormal transaminases with isoniazid. @RheumNow #ACR22 Abstr#0816 https://t.co/xiL6DPPcw3 https://t.co/jjxRoEr8iM
Richard Conway RichardPAConway ( View Tweet)
Khidir et al. Lower educational level increases risk of progression of clinical suspect arthralgia to inflammatory arthritis. HR 2.35 and 5.72 in 2 cohorts. not explained by smoking, BMI or a delay in seeking medical care @RheumNow #ACR22 Abstr#0704 https://t.co/B4bm2Ihapx https://t.co/Veks0WpHLR
Richard Conway RichardPAConway ( View Tweet)
Ab1042 #ACR22 Ixekizumab Long-term Safety
A Deodhar: Pooled 25 studies for PsO, PsA, AS
5.4 pooled AE per 100-patient/year
0.5 IBD per 100-PY
1.3 Oral candidiasis per 100-PY
Re-assuring safety numbers. Deodhar: "These are numbers to use in clinical practice"
@RheumNow
Eric Dein ericdeinmd ( View Tweet)
Hamroun et al. Unfavourable pregnancy outcomes associated age, nulliparity, steroids in RA. Can only modulate the final one! @RheumNow #ACR22 Abstr#0955 https://t.co/Vob1GeMN25 https://t.co/CsVshIzp8a
Richard Conway RichardPAConway ( View Tweet)
de Hooge & al: parameters assoc w/ risk of developing syndesmophytes at 2 yrs in PsA:
Radiographic SI according to mNY = 30x higher risk
If Rx SI + CRP>6 = 100% risk devlpmt syndesmophytes @ 2 yrs.
https://t.co/CR0LymrQdr
Abs#1014 #ACR22 @Rheumnow
#ACRBest https://t.co/TLWYCJ0eYi
Aurelie Najm AurelieRheumo ( View Tweet)
Rouhi @Janetbirdope et al RS3PE post checkpoint inhibitor. 11 cases. Can flare after checkpoint inhibitor reintroduction and occur following treatment. @RheumNow #ACR22 Abstr#0758 https://t.co/KCzdJvD0da https://t.co/WQ4eB2hz1k
Richard Conway RichardPAConway ( View Tweet)