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Slow pruning of Pulmonary arteries occurs way before we detect #PAH pulmonary hypertension in #scleroderma #SSc 13S114 lecture by Fred Wigley. Screen but need data re earlier Rx before Dx of PAH. May be assoc w anticentrome and +++ telangiectasia @RheumNow #ACR22 https://t.co/AgnIMYFKjB
Janet Pope Janetbirdope ( View Tweet)
#ACR22 Abstr#1464 Press Release #lupus. Should we worry of pts without nephritis & low grade proteinuria UPCR >0.2 & <0.5? A cohort study showed 50% progressed to =>0.5 at 2 yrs & 11% renal biopsy +ve. Important to monitor UPCR. Need biomarkers for this At-Risk @RheumNow #ACRBest https://t.co/eOODUynvP4
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
PCP docs managing AS?
Abstract #0078
🧑⚕️ Assessed differences in management between PCP and rheumatologists
💉RHU prescribed more biologics
💊PCP prescribed more opiate and non-opiate pain medications
💊PCP did not often prescribe csDMARDs or biologics
#ACR22 @RheumNow
Catherine Sims, MD DrCassySims ( View Tweet)
1918 influenza brought us proper design of vaccine trials as well as discovery of the influenza virus
@RheumNow #ACR22 @HRheuminations https://t.co/RlNXSWMWBz
Julian Segan JulianSegan ( View Tweet)
Please see my short review on new data and progress of BAFF/APRIL inhibition in #lupus #SLE presented at #ACR22 @RheumNow https://t.co/pqxdAcMH5e https://t.co/9IIrxVZvGe
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Ab0575 #ACR22 MI/CVA in Osteoporosis Pts on DEN/ ZOL, L Spangler
DEN pts more likely CKD, adjusted analysis
At 36 mos, risk for Den vs Zol in 2 database claims:
- MI: 0.97, 1.22 (0.8-1.7)
- CVA: 0.9 (0.6-1.2), 1.0
No incr. risk identified with Den vs Zol in MI or CVA
@RheumNow https://t.co/hgyG1ZmFLT
Eric Dein ericdeinmd ( View Tweet)
Other potential mechanisms for survival selection against the plague via MHC presentation to CD8 T cells. May be associated with SpA/HLA B27
@RheumNow @HRheuminations #ACR22 #rheuminations https://t.co/Rv117B4IYp
Julian Segan JulianSegan ( View Tweet)
Dr. Wigley describes the edematous phase of early #scleroderma:
☝️ Friction rubs are a sign of active disease and assoc. with poor outcomes
#ACR22 @RheumNow @rheumarhyme https://t.co/ooXYp1wXzu
sheila RHEUMarampa ( View Tweet)
Did you know that the first virus, the tobacco mosaic virus, was described in 1892? @AdamJBrownMD gave a fascinating lecture today regarding that included the history of viruses. #ACR22 @RheumNow
Dr. Rachel Tate uptoTate ( View Tweet)
Ab0577 #ACR22 Sao Paulo Aging & Health (SPAH)
Radius 1/3 BMD enhance fx risk estimates when combined w/ spine (RR 1.4, p=0.03)
For radius+hip or radius+spine/hip, radius DEXA is non-significant - only hip predicted fx
Use radius BMD when hip unattainable- THA/severe OA
@Rheumnow
Eric Dein ericdeinmd ( View Tweet)
Save the date! RheumNow Live is back on 3/18-3/19 in Dallas, Texas.
Register now!
https://t.co/tgce0Mydeh
#RNL23 #ACR22 https://t.co/XI6hcxuNEn
Links:
Dr. John Cush RheumNow ( View Tweet)
Do you know the 3 types of Y. Pestis plague? @AdamJBrownMD reviews the Bubonic, Pneumonic, and Septicemia plagues at #ACR22 @RheumNow. Most recently, there was an outbreak of Pneumonic plague in Madagascar in the 2010s!
Dr. Rachel Tate uptoTate ( View Tweet)
MEFV mutation protected against the plague. Protected against deactivation of inflammasome by yersinia pestis.
@RheumNow #ACR22 #rheuminations https://t.co/OqBay6Svdb
Julian Segan JulianSegan ( View Tweet)
GM-CSF/mavrilimumab in GCA masterclass from Maria Cid this morning.
Sadly, as John Stone & Sharon Chung ask and Maria Cid reflects on, we're not sure what happens next, despite the promising phase 2 & elegant MOA.
No current plans for a mavrilimumab GCA phase 3
#ACR22 @RheumNow https://t.co/c5PSqnFnC2
David Liew drdavidliew ( View Tweet)
Ab0574 #ACR22: Osteoporosis in Men - Under-recognized? Under-Screened? Under-Diagnosed!
@AMollaeianMD: Retrosp study >65 yo
<1% M have DEXA compared to 7-10% in F in 2010, 2018, and 2021
Hip fx 4.1% F, 3% M
DEXA declined in M between 2010-2018, no change in 2021
🦴🦴🩻
@RheumNow https://t.co/LbmxLnIX1Q
Eric Dein ericdeinmd ( View Tweet)
How to prescribe methotrexate in a post-Roe era:
Abstract #L09
💊 6% of > 1,700 patients reported access issues to MTX
-63% had a delay in filling script
🤰Excessive questions about possibility of pregnancy
🧑⚕️Pharmacy refused to fill
#ACR22 #ACRbest @RheumNow
Catherine Sims, MD DrCassySims ( View Tweet)
#ACR22 Abstr#0799 Is Evusheld effective in patients on B-cell depleting therapies? Early data (Jan-May 22) from @CCalabreseDO @LCalabreseDO are encouraging: 13/417 (3%) breakthrough infection in fully vac pts, 1 hospitalised. More data needed for Omicron subvariants @RheumNow https://t.co/g4Y1IMO67X
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
RheumNow’s expanded coverage of the #ACR22 Annual meeting is sponsored in part by Novartis. All content chosen by RheumNow and its Faculty
Dr. John Cush RheumNow ( View Tweet)
#ACR22 Abstr#0783. Rituximab impacts on humoral immunity. Our study on 400 RMD pts showed:
Breakthrough infection 30% mostly mild; Severe 4%; 1 death
Poor outcomes predicted by comorbidities & low IgG
Risk reduced by 50% with each vac dose
OK for RTX if vaccinated @RheumNow https://t.co/xyJsukm1Rh
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
☝️Remember: Not all skin thickening is SSc!
🔸Lipodermatosclerosis is a differential. Has an inverted champagne bottle appearance - caused by venous stasis and venous HTN
#ACR22 @RheumNow #Scleroderma #RheumTwitter https://t.co/joWWn6BnVC
sheila RHEUMarampa ( View Tweet)