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Song et al. Korean study shows better persistence of tocilizumab than TNFi as first-line biologic in RA. No difference in incidence of TB. @RheumNow #ACR22 Abstr#0887 https://t.co/EuQkfDZd77 https://t.co/VxJmKEzAVY
Richard Conway RichardPAConway ( View Tweet)
Lanz et al. Inverse relationship between number of ACPAs and subclinical ILD. Effect appears confined to African American and Hispanic participants. Not sure what to make of this at all. @RheumNow #ACR22 Abstr#1203 https://t.co/Ok3PCLFyxe https://t.co/UHlI6HOUmc
Richard Conway RichardPAConway ( View Tweet)
Deodhar et al. Bimekizumab (IL-17A/Fi) in nr-axSpA. Efficacy shown across all outcomes. Confirms bimekizumab works across spectrum of axSpA (not surprisingly). @RheumNow #ACR22 Abstr#0544 https://t.co/XVGBgBQpTH https://t.co/39zW5Ex9xh
Richard Conway RichardPAConway ( View Tweet)
Hanlon @MeganHanlon4 @dougveale et al. Loss of macrophage homeostasis occurs in pre-RA, and appears to be an early factor in RA development
@RheumNow #ACR22 Abstr#0554 https://t.co/UL1jVGVlrA https://t.co/i1WWQlHs2m
Richard Conway RichardPAConway ( View Tweet)
Proft @ProftDr et al. NSAIDs+golimumab no better than golimumab monotherapy in reducing spinal progression in AS. But... for high risk patients there may be some benefit - see figure. @RheumNow #ACR22 Abstr#0546 https://t.co/xo9Uy6aX71 https://t.co/vZgaoeEQn4
Richard Conway RichardPAConway ( View Tweet)
Weinstein et al. GO-BACK. Another TNFi withdrawal study in nr-axSpA. Again showing it doesn't work. 12 months. Only 34% of withdrawal group in remission vs 84% full dose and 68% reduced dose group. @RheumNow #ACR22 Abstr#0545 https://t.co/Fa5YgT9FYk https://t.co/9C8ShI9qjk
Richard Conway RichardPAConway ( View Tweet)
Day 2: Tips to avoid burnout. I know it’s Sunday morning but a dose of #physicalactivity will keep the mind and body sane. Dare to accept challenge? #ACRVirtual5K Run #ACR22 #rheumatologyrunners #wellbeing #foggy @RheumNow #RheumPix https://t.co/N9ulz8KPVw
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Broder et al. HCQ alone vs steroid alone as maintenance in ESKD due to SLE. HCQ less cardiac events, less infection. @RheumNow #ACR22 Abstr#0539 https://t.co/mb3Eof2Uiv https://t.co/3i3ZTY25ru
Richard Conway RichardPAConway ( View Tweet)
Rech et al. 18 month results of ARIAA, 6 months abatacept in pre-RA, 1 year drug-free follow-up. 35% vs 65% developed RA. MRI response 57% vs 29%. @RheumNow #ACR22 Abstr#0530 https://t.co/35M2sPkIbW https://t.co/S8K39jkCh0
Richard Conway RichardPAConway ( View Tweet)
Ab0675 #ACR22 DAH in APLS
61 pts w APS, incident DAH
85% h/o VTE, 51% thrombocyt 43% valvulopathy
74% were on a/c at time of DAH
Relapse rate: 41% at 1 yr, 26% w/in 6 mos!!!
Risks: triple pos, thrombocyt, IVIG, PLEX, ventilation
Mortality 19% 1 yr, 38% 5 yrs
@RheumNow #ACRBest https://t.co/g1uz2Giilc
Eric Dein ericdeinmd ( View Tweet)
Ab0676 #ACR22 Adrenal hemorrhage in APLS
59 pts from SLE cohort + 181 from lit review
65% prior VTE, 12% CVA, 24% OB morbidity
46% thrombocyt, 21% had SLE
58% on a/c
69% b/l hemorrhage
63% adrenal insuff
Radiol remission: 6% at 1 yr, 41% at 5yr
Death 2% 1 yr, 11% at 5
@RheumNow https://t.co/EacifcN7Sd
Eric Dein ericdeinmd ( View Tweet)
Ab0683 #ACR22
aPL Pts ANA pos vs neg:
521 pts with +aPL Ab WO other autoimmune disease
224 +ANA, 297 -ANA
ANA+ ass w/ hemolytic anemia, thrombocyt, leukopenia, livedo, unexplained fetal death
Trend for arthritis, aPL nephropathy
@RheumNow https://t.co/3NHGymyL1C
Eric Dein ericdeinmd ( View Tweet)
Ab0685 #ACR22 APLS and prior COVID infection
TKR patients at HSS:
1/5 of patients had positive aPL Ab, mostly low level aCL IgM
Not associated with COVID infection or SARS-CoV-2 Ab
@RheumNow https://t.co/HJpnUOrrxc
Eric Dein ericdeinmd ( View Tweet)
Schieir et al. Women with early RA less likely to achieve remission. 12 months 37% vs 43%. 4 years 61% vs 64%. Time to remission 19 months vs 16 months. @RheumNow #ACR22 Abstr#0532 https://t.co/ZRuqqaPHHU https://t.co/pDBHHtLEhs
Richard Conway RichardPAConway ( View Tweet)
🧨Late breaking abstract🧨 #ACR22 @RheumNow #ACRbest
Identifying fetal myocardial targets in congenital heart block (CHB)
Abstract #L13
🫀maternal serum underwent mass spec. that identified Ab to 4 protein targets that predicted CHB including anti-ATP1A1 as early as 7w
Catherine Sims, MD DrCassySims ( View Tweet)
Porter et al. Asymptomatic Pre-RA to symptomatic Pre-RA to early RA steady increase in bacterial infection compared to HC. Causality or Reverse Causality? I think more likely reverse - disease related immunosuppresion @RheumNow #ACR22 Abstr#0535 https://t.co/i5iN3Db7rf https://t.co/2ynYF7Vqbl
Richard Conway RichardPAConway ( View Tweet)
Ab0674 #ACR22 HIT AND APLS??
Retrosp review of 23 pts treated for HIT in the hospital with APLS or SLE with aPL Ab:
Not one ultimately met clinical criteria for HIT
1 pt had PF4 antibodies, SRA testing negative in ALL cases
Thrombocytopenia w/ aPL Abs? Think APS 1st!
@Rheumnow https://t.co/ZYZP5VZF0R
Eric Dein ericdeinmd ( View Tweet)
Ab0673 #ACR22 Occurrence & Severity of ITP w or w/o APLS antibodies
Fewer bleeding events in ITP patients w/ aPL antibodies (15% vs 43%) compared to w/o aPL antibodies
Despite more use of a/c and lower median patients in aPL patients
Is aPL Ab a good prognosis for ITP?
@RheumNow https://t.co/yLBVUN2T0L
Eric Dein ericdeinmd ( View Tweet)
Hear Dr. @AngusWorthing discuss advocacy and more legislative updates at #ACR22 @RheumNow https://t.co/zD8xpcCzi2
Dr. Rachel Tate uptoTate ( View Tweet)
IL17A/Fi BImekizumab BKZ to Wk 24 achieved reduction in
◦ total spinal pain (SP)
◦ nocturnal SP
◦ morning stiffness (BASDAI)
◦ fatigue (FACIT-F)
Deodhar et al, BE MOBILE 1,2 Abst 0409 https://t.co/vpCrG2COuB
#ACR22 @RheumNow
Dr. Antoni Chan synovialjoints ( View Tweet)