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What to do about pre-clinical RA?
RheumNow Live’s 2023 conference led with this year’s hot topic of rheumatoid arthritis, and in particular, what to do regarding pre-clinical RA.
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Psoriatic Arthritis and Pregnancy
At RheumNow Live this weekend, Dr. Christina Chambers, an epidemiologist at the University of California San Diego and the principal investigator of MotherToBaby Pregnancy Studies, reviewed the available data on psoriatic arthritis and pregnancy. There is little evidence at this time that pregnancy affects PsA, though studies reliably demonstrate increase in disease activity in the post-partum period in both skin and joint disease.
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The AURORA study with voclosporin has changed the way that Dr. Kalunian practices. He now uses lower doses of steroid, 40mg in induction with a faster taper in lupus nephritis. #RNL2023 @RheumNow https://t.co/8ss14Z5WXl
Dr. Rachel Tate uptoTate ( View Tweet)
⚠️Beware not all bone marrow oedema =#AxSpA on MRI !
Signal seen in 17% volunteers at SIJs
@DrPoddubnyy
#RNL2023 https://t.co/rksQin3tmD
Dr Gurdeep Dulay gurdeep_dulay ( View Tweet)
Future treatment for #AxSpA ?
Promising data for #Bimekizumab
Inhibits IL-17 A and F
#RNL2023 https://t.co/H2euMPgIFj
Dr Gurdeep Dulay gurdeep_dulay ( View Tweet)
Dr. John Reveille on genetic sharing between AS, PsO, and IBD
- multiple overlapping genetic signals
@RheumNow #RNL2023 https://t.co/p3gvfTO732
Robert B Chao, MD doctorRBC ( View Tweet)
Late onset Inflammatory back pain?, Reveille #RNL2023 @RheumNow https://t.co/G0LOgjmBvj
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Reassuring data by Dr. Laurent Arnaud on HCQ
- arrhythmia risk from HCQ similar to general population
@RheumNow #RNL2023 https://t.co/vMDg2SlbJQ
Robert B Chao, MD doctorRBC ( View Tweet)
Great tips for #AxSpA monitoring
and
🚩 red flags for radiographic progression 🚩
❌No need for routine imaging follow-up
#RNL2023 @deodhara https://t.co/PAFtHIrqRF
Dr Gurdeep Dulay gurdeep_dulay ( View Tweet)
A Pilot Trial of Anifrolumab in Discoid Lupus
A research report in JAMA Dermatology describes the use of the type 1 interferon receptor inhibitor anifrolumab in patients with chronic discoid lupus erythematosus (DLE).
https://t.co/MwruMhmvPq https://t.co/WnCvCZtq6z
Links:
Dr. John Cush RheumNow ( View Tweet)
Is AS transmission to offspring more common from the mother or father?
- hard to say, some studies (including Swiss and UK studies) show mothers play a larger role
- other studies show fathers do
@RheumNow #RNL2023 https://t.co/Vr1qUy5Y6b
Robert B Chao, MD doctorRBC ( View Tweet)
AxSpA is primarily a genetic disease
- clusters in families, especially HLA-B27+ first degree relatives
- genetic testing for asymptomatic relatives not recommended
@RheumNow #RNL2023 https://t.co/vhBlNlXMHR
Robert B Chao, MD doctorRBC ( View Tweet)
New download available!
VTE Risks and JAK inhibition
https://t.co/TCt4PcySYr https://t.co/wBaEsC3Wry
Links:
Dr. John Cush RheumNow ( View Tweet)
BEAT LUPUS trial results showed that belimumab after RTX reduced dsDNA levels/flaring. Questions remain if this can be a successful combination in lupus nephritis. Dr. Kalunian #RNL2023 @RheumNow https://t.co/XeuybrWigf
Dr. Rachel Tate uptoTate ( View Tweet)
"I think rheumatologists are great observers, they just need to try meds." Dr. Furie regarding new medications/indications in rheumatology. #RNL2023 @RheumNow
Dr. Rachel Tate uptoTate ( View Tweet)
Awareness increased for this disease , BY Atul Deodhar #RNL2023 @RheumNow https://t.co/MSBrYU5Pb4
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
#RNL2023 @RheumNow
Atul Deodhar:
Prevalence of AS is increasing!
Is it truly more? Or likely better recognized and diagnosed, as well as increased recognition of nr-AxSpa https://t.co/qNwUg5RtaG
Eric Dein ericdeinmd ( View Tweet)
Atul Deodhar's "3-4-5" Rule for MRI Sacroiliac Jts (SIJ)
Erosion in 3+ SIJ quadrants
Bone marrow edema 4+ SIJ quadrants
Fat lesion in 5+ SI joint
@Rheumnow #RNL2023 https://t.co/AHZUhhEmmC
Eric Dein ericdeinmd ( View Tweet)
Dr. Deodhar reminds us of his "3,4,5 rule" for diagnosing AS.
*Erosions in 3 or more SIJ quadrants
*BME in 4 or more SIJ quadrants
*Fat lesions in 5 of more SIJ quadrants
#RNL2023 @RheumNow https://t.co/2m8TmkQo0A
Dr. Rachel Tate uptoTate ( View Tweet)
Dr. Atul Deodhar on AxSpA
- 5-40% of nr-axSpA progress to r-axSpA over 2-10 years
- is non-radiographic axSpA a misnomer?
@RheumNow #RNL2023 https://t.co/bhwlbg6eWN
Robert B Chao, MD doctorRBC ( View Tweet)
