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NSAIDs Linked to Heart Failure in Diabetes Patients

d EurekAlert!

Short-term use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with a first-time hospitalisation for heart failure in patients with type 2 diabetes, according to research presented at ESC Congress 2022.

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pregnancy,doctor,consult

Are We Overcautious With TNF Inhibitors in Pregnancy?

d MedPage Today

What may seem like a prudent approach to treatment of inflammatory bowel disease (IBD) in pregnant women actually represents an overabundance of caution, suggested researchers who found no increased risk from tumor necrosis factor (TNF) inhibitors.

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sleep,man,dream

Immune Benefits to Sound Sleep

d Jack Cush, MD

The revitalizing powers of sleep are numerous but what are the consequences to inadequate sleep? A current report in the Journal of Experimental Medicine shows the connection between sleep and immune function as measured in mice and humans; specifically, a good night’s sleep promotes normal production and programming of hematopoietic stem cells. 

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ACR20 Capitol

Rheumatology Leaders and Patient Advocates Convene on Capitol Hill

d ACR

ACR members along with rheumatology patients gathered on Capitol Hill and urged federal lawmakers to support the HELP Copays Act, Safe Step Act, and Improving Seniors’ Timely Access to Care Act.

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3 Large cohort (OAI, MOST, CHECK) looked at 9683 knees (incidence cohort) & 6075 knees (progression cohort) showing increase in BMI assoc w/ incidence (OR 1.05) & progression (1.05). BMI also assoc w/ degeneration & JSN hip & medial knee https://t.co/VAU2UJRQ8O https://t.co/QBl2wt0FrN

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Dr. John Cush RheumNow ( View Tweet)
Is there a link between PsA & autoinflammatory disease? Dr. Cush reviews a recent study of 120 #PsA patients in our latest podcast. https://t.co/b15zmfXACa https://t.co/aCY08xXtPw

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Dr. John Cush RheumNow ( View Tweet)

ASBMR 2022 study shows Patients w/ serum ferritin > 1000 µg/L or Dx hemochromatosis or thalassemia — were 60% more likely to have an osteoporotic fracture (2X risk vertebral Fx) during an up to 10-year follow-up https://t.co/uLf8zTiMml https://t.co/9KnApUxxTF

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Dr. John Cush RheumNow ( View Tweet)
VTE Risk from Swedish Rheumatology Quality Register - VTE Prevalnce/1000PY TNFi 5.15; JAKi 11.33; Gen Pop 3.3. VTE adj HR JAKi vs TNFi =1.73 (1.24, 2.42); PE HR 3.21 (2.11, 4.88) and DVT HR 0.83 (0.47,1.45) https://t.co/WclcFpX3aI https://t.co/r1FXSZNcYJ

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Dr. John Cush RheumNow ( View Tweet)
Analyses of data from the Nurses Health Study (1986-2016) & NHSII (1989-2017) cohorts shows chronic low sleep duration (< 5hrs/night vs >7hr/night) was assoc w/ increased SLE risk (adj HR 2.47). Low sleep also assoc w/ body pain(2.13), depression(HR 2.82) https://t.co/I9oCDQyulz https://t.co/vjRFDXf0EZ

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Dr. John Cush RheumNow ( View Tweet)
IL-18 is a proinflammatory cytokine involved in innate &adaptive immune responses. IL-18 is a key mediator in autoinflammatory diseases, MAS, Still’s disease. Serum IL-18 levels may be useful in diagnosis and monitoring of disease activity https://t.co/IB9CwbILD9 https://t.co/TWNnjJyR2Z

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Dr. John Cush RheumNow ( View Tweet)
Medicare (1,654,862 pts) cohort matched study included 3.6% w/ rheumatic IMIDs w/ MI. Rheum IMIDs were younger, women, w/ non–STEMI, less angiography/Stent/CABG & have higher mortality (aHR 1.15), CHF (1.12) & recurrent MI (1.08) https://t.co/SxemjO7GA2 https://t.co/VKg1f4yd2M

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Dr. John Cush RheumNow ( View Tweet)
Cancer Risk with Scleroderma Spanish Scleroderma Registry examined a large cohort of systemic sclerosis (SSc) patients showing an increased cancer risk, especially breast, lung, hematologic and colorectal cancer. https://t.co/9w53NO3AsU https://t.co/bSkFhTN3v2

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Dr. John Cush RheumNow ( View Tweet)
Is PMR the Next Indication for Tocilizumab? About half of patients with steroid-dependent PMR were able to get off steroids altogether when they were started on tocilizumab (Actemra) infusions, a randomized phase III trial showed. https://t.co/Ea7XIqViRj https://t.co/h65OSjoytg

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Dr. John Cush RheumNow ( View Tweet)
Clinical Profiles Seen with NXP-2 Antibodies A recent review of the myositis associated autoantibody NXP-2 profiles its clinical associations with dermatomyositis (DM), calcinosis, severe myositis and, in some reports, with cancer. https://t.co/oCgb1f2Avw https://t.co/rnMa4jHhNy

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Dr. John Cush RheumNow ( View Tweet)
Yoga Fails to Benefit Knee Osteoarthritis The Annals of Internal Medicine has published a study showing online yoga education and an unsupervised yoga program may improve physical function did not improve knee pain after 12 weeks and 24 weeks. https://t.co/9n31mTpudX https://t.co/WettcMpBLi

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Dr. John Cush RheumNow ( View Tweet)
IL-6i in Behcets? Lit Review finds 25 articles papers, 74 pts (31 TNFi naive, 45 TNFi prior Rx). Pts Rx w/ tocilizumab IV. TCZ given for vascular, CNS , ocular & mucocutaneous. TCZ was effective in 87% TNF naive & 80% in TNFi Experienced pts. https://t.co/u1jnR9gb1L https://t.co/Rkqch4MVWi

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Dr. John Cush RheumNow ( View Tweet)
Is there link between PsA & autoinflammatory Dz? Study of 120 #PsA pts found 31% w/ AID gene variants (AP1S3, PLCG2, NOD2, NLRP12, all monoallelic variants adn 1/2 genes assoc w/ autosomal dominant disorders. https://t.co/1cVFErPV6o https://t.co/QtRHrZJLJI

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Dr. John Cush RheumNow ( View Tweet)
Hydroxychloroquine Dosing and SLE Flares JAMA cohort study examining HCQ dosing in patients with SLE suggests that HCQ doses of 5 mg/kg per day or less, was associated with a higher risk of lupus flares, including moderate or severe lupus flares. https://t.co/1krevZo64c https://t.co/XEybtcFvNR

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Dr. John Cush RheumNow ( View Tweet)
STAR-RA study - real world claims data shows tofacitinib doesnt increase malignancy risk. Study of 83,295 pts (10,504 TOFA). Risk of malignancy w/ TOFA not increased (HR 1.01) w/ RWE or RCT-duplicate cohort (HR 1.1; 95% CI 0.85, 1.62) https://t.co/9YWmXBTkWf

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Dr. John Cush RheumNow ( View Tweet)

RINOMAX Trial studied single dose of 500 mg rituximab IV in myasthenia gravis - 47 MG pts randomized to RTX or PBO, after 4 mos RTX response (71% vs 29%) superior to PBO. Further studies are needed https://t.co/ffko7uMpk7

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Dr. John Cush RheumNow ( View Tweet)

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