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Pathogenic Impact of microRNA Cotargeting in Lupus
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EurekAlert!
A group of researchers from the Graduate School of Medicine at Nagoya University in Japan have discovered the impact of microRNA (miRNA) on inflammation in lupus in mice.
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Simon Says “Don’t Do This” (1.27.2022)
Dr. Jack Cush reviews this week’s journal articles, focuses on studies that should not have been done and responds to viewer questions in Ask Cush Anything.
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What separates a Great Rheum from an Elite Rheumatologist?
Dr. John Cush RheumNow ( View Tweet)
Skin manifestations in MDA5 phenotype #inflammatorymyopathy
✅Punched out ulcers on arm, forearm, extensor aspect of elbow
✅Extensive ulcers in PIP and DIP creases
✅Vasculitic rash over fingers with digital ischemia and erythematous palmar papules
👉https://t.co/hUc6Lakww0 https://t.co/smJ1BrSWGc
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MJR MJR_journal ( View Tweet)
Variable Pregnancy Outcomes with Belimumab in SLE
An analysis looked at outcomes in pregnant SLE exposed to belimumab reported there are few pregnancies and confounding disease and comorbidity factors to provide clear guidance for such patients.
https://t.co/nBzoyL4cHW https://t.co/UYIAsfRtB8
Links:
Dr. John Cush RheumNow ( View Tweet)
"Dry Synovitis" exist in juvenile arthritis pts? Study of 12 DS pts, says its different from Poly #JIA; onset 6.1 yrs, w/ polyarthritis, no palpable swelling, progressive LOM/contractures, neg ESR/CRP/RF/CCP, +MRI synovitis w/ osteochondral involvement.https://t.co/okGPCsIPNs https://t.co/XlFhgTtq5b
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Dr. John Cush RheumNow ( View Tweet)
Why not end your patient visit with a recitation pledging your service and commitment:
"Your coming to see me to day is very important, to the both of us. I pledge to be of service to you. Together WE can certainly improve your health" https://t.co/HrzbipL1ZG https://t.co/amDCk309wi
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Dr. John Cush RheumNow ( View Tweet)
JAK-pot Study: To Cycle or Switch after JAK inhibitor Failure?
Data from 17 international registries suggest that for RA patients failing their first JAKi, it did not matter if they were cycled to another JAKi or switched to a bDMARD.
https://t.co/WunRxeF5Wm https://t.co/cOIjglnPNU
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Dr. John Cush RheumNow ( View Tweet)
Subanalysis of Scleroderma Lung Study II (MMP vs CTX in SSc-ILD) showed pt reported GI reflux (~moderate) was independently associated with the change ILD and fibrosis over two years (but not so for esophageal dilation) https://t.co/5Gz2vfOock https://t.co/N2FsvNe24M
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Dr. John Cush RheumNow ( View Tweet)
AS, but not PsA, has Increased Mortality Risk
A recent meta-analysis showed a significantly increased risk of overall mortality in ankylosing spondylitis (AS) but not psoriatic arthritis (PsA), largely associated with cardiovascular-specific mortality.
https://t.co/bi3q7LW4S6 https://t.co/DUc9sB4MI0
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Dr. John Cush RheumNow ( View Tweet)
Simon Says “Don’t Do This”
Dr. Jack Cush reviews this week’s journal articles, focuses on studies that should not have been done and responds to viewer questions in Ask Cush Anything.
https://t.co/ZisyCRxV6L https://t.co/inYDkKKJO3
Links:
Dr. John Cush RheumNow ( View Tweet)
CDC: Nursing home residents not up to date w/COVID-19 vaccines have 30%–50% higher risk for COVID infx vs those up to date. Betw 2022-23 Those vax had COVID rate of 7.2-15.6/1000pts vs 9.5-18.8/1000 pt in those unvaccinated. https://t.co/Eem2H5AMoN https://t.co/o2ZyPVswZp
Links:
Dr. John Cush RheumNow ( View Tweet)
VEXAS may be more common than expected
A great study of a recently described rheumatologic/hematologic disorder VEXAS syndrome recently appeared in JAMA, describing the frequency and presentations of UBA1 variant.
https://t.co/OFaeH62eHy https://t.co/7znps74Llv
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Dr. John Cush RheumNow ( View Tweet)
Blood Test Identifies Osteoarthritis Progression
A new blood test that can identify progression of osteoarthritis in the knee is more accurate than current methods, providing an important tool to advance research and speed discovery of new therapies.
https://t.co/hOAjxJhnJG https://t.co/Ehr5imPNQ4
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Dr. John Cush RheumNow ( View Tweet)
A Shortage of Trust
I’ve oft heard the truism that “Trust is in short supply”. This is so true. Those I value most, are the ones I trust the most. My nurse practitioner, my front desk gal, my medical partner, and my best friend...
https://t.co/AXIDAJQUta https://t.co/GJwQq04dUC
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Dr. John Cush RheumNow ( View Tweet)
Join us on 3/18 and 3/19 in Dallas, Texas or virtually for RheumNow Live!
Who is coming?
https://t.co/LLUufQDhHv https://t.co/nKTN5KBtuc
Links:
Dr. John Cush RheumNow ( View Tweet)
Variable Pregnancy Outcomes with Belimumab in SLE
An analysis looked at outcomes in pregnant SLE exposed to belimumab reported there are few pregnancies and confounding disease and comorbidity factors to provide clear guidance for such patients.
https://t.co/pkyAcE0aNr https://t.co/MB4AGmtSdp
Links:
Dr. John Cush RheumNow ( View Tweet)
702 #SLE pts (age 29 yrs) from India, measured plasma 25-hydroxyvitamin-D(25(OH)D) - median levels were 22.83 (13.8–31.8) ng/ml. Low Vit D(< 20) seen in 41.5%; correlated w/ age/geography, & weak neg correlation w/ weak negative correlation w/ SLEDAI2K https://t.co/EUPqJGKAhI https://t.co/MEIL5yd64n
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Dr. John Cush RheumNow ( View Tweet)
Early Ph IIa study of ATI-450 (Zunsemetinib), an investigational selective MAP kinase–2 (MK2) blocker leds to a sustained antiinflammatory effect; studied in 19 RA pts w/ ACR 20/50/70 of 60%/33%/20% at wk 12. https://t.co/IyjJCgdXG2
Links:
Dr. John Cush RheumNow ( View Tweet)
"Dry Synovitis" exist in juvenile arthritis pts? Study of 12 DS pts, says its different from Poly #JIA; onset 6.1 yrs, w/ polyarthritis, no palpable swelling, progressive LOM/contractures, neg ESR/CRP/RF/CCP, +MRI synovitis w/ osteochondral involvement.https://t.co/tL2G7QKBL4 https://t.co/k4QoAmTGYA
Links:
Dr. John Cush RheumNow ( View Tweet)
