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virus,injection,COVID,vaccine

FDA Approves BA.4 and BA.5 Omicron COVID Booster Vaccines

d Jack Cush, MD

Today the FDA authorized the updated Omicron subvariant (BA.4 and BA.5) COVID-19 booster shots manufactured by Pfizer and Moderna; with an anticipated ship/start date of early September 2022. The BA.5 subvariant accounts for more than 88% of U.S. infections.

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MTP1,gout

NICE Guidelines on Gout Diagnosis and Management

d Jack Cush, MD

NICE (UK) has systematically reviewed current medical evidence and delivered a set of recommendations with consideration of cost effectiveness.

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Prevalent Sleep Problems in Rheumatoid Arthritis

d Jack Cush, MD

Data from Data FORWARD (The National Databank for Rheumatic Diseases) reveals that nearly two-thirds of rheumatoid arthritis (RA) patients have self-reported sleep problems.

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Disease Activity Scoring in Adult-onset Still's disease

d Jack Cush, MD

Still's disease in adults (AOSD) or children (sJIA) can have dramatic symptom severity, making it easy to gauge disease activity and response to therapy, especially at the outset. However, a validated measure of disease activity has not been agreed (for clinical trial and treatment assessments). A new study compares two such activity measuresin a large cohort of Still's patients.

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Have you registered for RheumNow yet? With registration you'll be able to sign up for our daily email, as well as our topic specific emails. RheumNow is where rheumatologists come to learn. https://t.co/NuN8JL37tk https://t.co/urJGorSzxo

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Prevalent Sleep Problems in Rheumatoid Arthritis Data from Data FORWARD (The National Databank for Rheumatic Diseases) reveals that nearly two-thirds of rheumatoid arthritis (RA) patients have self-reported sleep problems. https://t.co/WHv3BBeI8T https://t.co/awSy2VqBIn

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Dr. John Cush RheumNow ( View Tweet)
Disease Activity Scoring in AOSD AOSD or sJIA can have dramatic symptom severity, making it easy to gauge disease activity and response to therapy, especially at the outset. However, a validated measure of disease activity has not been agreed upon. https://t.co/oD6uDD6W8m https://t.co/KxNJeJ31h8

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Dr. John Cush RheumNow ( View Tweet)
ANA Increasing? Part of the NHANES survey, ANA (IIF on HEp-2 cells) was performed on 13,519 in 3 periods: 1988-1991, 1999-2004, and 2011-2012. ANA+ was 11% 1988-1991 11.4% 1999-2004 16.1% 2011-2012 (P <0.0001) Meaning ~22.3, ~26.6, &~41.5 mil had +ANAs https://t.co/vWYJci3uDV https://t.co/SEIbrYRoRJ

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Dr. John Cush RheumNow ( View Tweet)
SURPRISED? Psoriasis pts have a known increased risk of CV disease. But did you know several papers & metanalyses show increased risk of abdominal aortic aneurysm in PSO (HR 1.30), worse w/ dz activity; lost w/ age, female, DM? https://t.co/UssLZsBJle https://t.co/ESGK8fjjJk https://t.co/CBBYZRCjCA

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Dr. John Cush RheumNow ( View Tweet)
Anti-PM-Scl connective tissue diseases - By Paul Breillat (Fellow in Internal Medicine, Paris, France) #connective #scleroderma #myositis #PMScl #InternistAcademy https://t.co/P727E4ddzz
Benjamin Terrier TerrierBen ( View Tweet)
✅ Probably one of my most important slides ⬇️ WHY IS MY #TREATMENT NOT WORKING (or not working enough) 😭 This is really a question we're dealing with everyday in #rheumatology when taking care of patients with #autoimmune and other rheumatic diseases 👍 https://t.co/osUPYSvuWf
Laurent ARNAUD Lupusreference ( View Tweet)
This precipitous drop and current level is substantially worse than 21 peer countries https://t.co/NAEMjhs4j3 https://t.co/QhrZ1Xnwcr

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Eric Topol EricTopol ( View Tweet)
In a nutshell, reducing glucocorticoids in #SLE patients is associated with a number of important clinical benefits and may impact risk of other comorbidities such as BP and infection risk. https://t.co/YBoIU6aK8p

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Ian N Bruce Lupusdoc ( View Tweet)

Life expectancy for Americans is the lowest it's been since 1996. Read about the decline from @sheridan_kate https://t.co/QwkOmOt2Tp https://t.co/wavGjOv6q5

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STAT statnews ( View Tweet)
Statin Myalgias? Lancet metanalysis of 19 PCTs, >80K pts, @ 1yr, Statin caused a 7% increase in muscle pain or weakness (1·07; 1·04–1·10); thus 1 in 15 had myalgia due to statin (1/10 w/ high dose). After year 1, no signif excess in statin related myalgia https://t.co/6cRJQMymzM https://t.co/RTH56J4FD1

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Dr. John Cush RheumNow ( View Tweet)
After historic drop in 2020 (COVID), life expectancy in USA dropped again, this time a full year to 76.1 years. The lowest since 1996 and the biggest 2-year decline in a century (dropping >2.5 yrs). To date, there have been 1,044,937 COVID deaths in USA https://t.co/aSgtw6MvGs https://t.co/0UKeyGujKe

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Dr. John Cush RheumNow ( View Tweet)
Tapering biologics in Still's/Systemic JIA? 4 studies suggests after sustained inactive disease achieved, options include QOD (anakinra) dosing or dose reduction or interval prolongation (CAN & TCZ). KEY: early biologic starts https://t.co/33tjr65Gi0 https://t.co/fi6fc4NPgG

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Dr. John Cush RheumNow ( View Tweet)
Study of Adult-onset Still's in Western Australia. Incidence = 0.22/100 000, prevalence = 2.4/100 000. AOSD had higher risk of previous liver disease (OR 2.67), serious infx (OR 4.36), joint replacement (OR 45.5), mortality not increased @ 1 & 5 yrs https://t.co/Wu0SQIMjWT https://t.co/Zvsdb2OR0y

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Dr. John Cush RheumNow ( View Tweet)
Autoimmune Disease Augments Cardiovascular Risk A large UK database study suggests that young adults with autoimmune diseases have an associated increased risk for cardiovascular disease. https://t.co/TtiH9ZBkR8 https://t.co/jVZBk8l4XD

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Dr. John Cush RheumNow ( View Tweet)
Review of cGAS/STING - enzyme cyclic GMP-AMP synthase. self genomic & mitochondrial DNA stimulates cGAS-->dimerizes & binds to the endoplasmic reticulum protein stimulator of IFN genes (STING), unleashing an inflammatory response https://t.co/g04v1S4PYJ https://t.co/SHeneZq4sd

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Dr. John Cush RheumNow ( View Tweet)

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