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Favorable Pregnancy Outcomes in Spondyloarthritis
Pregnancy often occurs in women with axial spondyloarthritis (axSpA), and a recent cohort study suggests outcomes are generally better than what had been reported in the literature.
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JUNIPERA Study - Secukinumab in Juvenile PsA & ERA
JUNIPERA study evaluated secukinumab (SEC) in children with enthesitis-related arthritis (ERA) and juvenile psoriatic arthritis (JPsA) and was found to be safe and effective in patients with active ERA and JPsA who previous failed to respond to conventional therapy.
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Black Adults Have a Higher Gout Risk
In a cross-sectional study of US adults, gout was more prevalent in black adults compared to white adults; possibly explained by sex-specific dietary differences and social determinants of health and clinical factors.
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Exciting news to announce! Our book "Telerheumatology: Origins, Current Practice, and Future Directions" is now available for download and has been published on SpringerLink. #telerheumatology #rheumtwitter #rheum https://t.co/rW0g6WByTp
Christine Peoples CPeoplesMD ( View Tweet)
Mass Gen Brigham study of Rheum (SARD) pts COVID severity over time (3/20-1/22) shows less severe COVID over time. 1449 SARD pts had COVID-19 (1/3 RA); 28% severe. Early COVID was more severe (46%) vs 15% w/ Omicron. Unvax were more severe (78% v 60%) https://t.co/DTge2od82Q https://t.co/LXeujT6zd5
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Dr. John Cush RheumNow ( View Tweet)
Has insurance moved to a new tactic to intimidate doctors from appeals? I was expecting to do a peer to peer to get #Xeljanz approved, they put me on the phone with a courtroom judge to make me swear I am telling the truth about why the medicine is needed for the patient.
TheDaoIndex KDAO2011 ( View Tweet)
Biosimilar switching is due to costs, formulary, relocation. Study of 23 studies, 3657 pts found only observational data, no RCTs. Ref product to biosimilar usually RCTs; Biosimilar switches usually real world evidence w/ good efficacy & no new risks. https://t.co/odAYHdbVd1 https://t.co/BabkVYsMBL
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Dr. John Cush RheumNow ( View Tweet)
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Dr. John Cush RheumNow ( View Tweet)
Recurrence of axSpA in 1st-degree relatives (FDR) probands w/ 35-yrs F/U. From 363 AS probands & 806 FDR, 27.1% of B27(+) FDR developed axSpA; 18.2% from AS probands; 4% from nr-axSpA probands. Recurrence higher with B27+ probands https://t.co/1xczXdtrH3 https://t.co/mXZ72nVAqp
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Dr. John Cush RheumNow ( View Tweet)
UK Women’s Cohort -diet & Hip Fx risk study shows that amongst 26,318 women, 822 hip Fxs - Hip Fx risk was higher in Vegetarians (HR 1.33; 1.03, 1.71)) but not meat-eaters (HR 1.00; 0.85, 1.18) or pescatarians (0.97; 0.75, 1.26); unaffected by BMI https://t.co/tipy0IBp4D https://t.co/sG0lJAUgDj
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Dr. John Cush RheumNow ( View Tweet)
Cochrane review of Stem cell transplantation in systemic sclerosis (3RCTs w/ 125 pts). Non‐myeloablative & myeloablative selective HSCT had moderate evidence for improved survival, skin thickness & function. But these had high Serious AE rates. https://t.co/d3CPsKiR88 https://t.co/QgCYBikhyl
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Dr. John Cush RheumNow ( View Tweet)
Urine-soluble CD163 as a biomarker in #SLE: usCD163 significantly higher w/ active lupus nephritis & correlates w/ UPCR, disease activity, anti-dsDNA Ab levels and a higher chronic kidney disease stage. https://t.co/Mxe53pCnEF https://t.co/BOspodqpSE
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Dr. John Cush RheumNow ( View Tweet)
Axial PsA frequency? Study of Derm identified PSO adults w/ chronic LBP, onset <45 yrs, not Rx w/ DMARDs--> 100 pts referred to Rheumatology; 14 pts dx w/ axPsA, 5 w/ peripheral PsA, & 3 w/ both axial & peripheral PsA https://t.co/oVxDcY17ZQ https://t.co/oIOfptskf3
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Dr. John Cush RheumNow ( View Tweet)
Let’s look at the timeline of major discoveries in AxSpA genetics, starting with HLA-B27 in 1972 https://t.co/f3AvYJodQj
ASAS Official_ASAS ( View Tweet)
Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease: a prospective cohort study https://t.co/1fiNgBQUbr looks like lower ab response and drops over 6 mths - boosters important in our patients
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Peter Nash drpnash ( View Tweet)
Global Mortality Rates for PsA, SpA and Colitis
Global age-standardized mortality rate (ASMR) for 1000000 was for 0.13 for AS, 0.04 for PsA, 0.86 for CD and 0.76 for UC.
https://t.co/0cZ9kZsiEM https://t.co/hDHojKBeRQ
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Dr. John Cush RheumNow ( View Tweet)
NEJM - Lupus Pernio in Sarcoidosis - 71 yoM w/ red nodules on his nose, ears, fingers, and toes. The lungs were clear on auscultation. Angiotensin-converting enzyme level of 102. https://t.co/Vy9XQlRVKl https://t.co/wlyx3D9FzC
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Dr. John Cush RheumNow ( View Tweet)
Utility of Repeat ENA Antibody Testing
Repeat serologic testing is not uncommon, but is it warranted? A retrospective study shows that repeated testing for autoantibodies to extractable nuclear antigens rarely changes the result or adds a new diagnosis.
https://t.co/ncXqSMz0Qo https://t.co/FxHKjJsga3
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Dr. John Cush RheumNow ( View Tweet)
Retrospective study of 99 Henoch-Schönlein purpura (HSP) pts complicated by GI bleeding (61 mild; 38 severe). Severe GIB assoc w/ sufmmer Onset, facial rash, HI D-dimer (>0.89 mg/L) & neutrophil-to-lymphocyte ratio (NLR >10.56). https://t.co/sI5LoONWGf https://t.co/ySdswRfkMg
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Dr. John Cush RheumNow ( View Tweet)
Should you do sural nerve biopsy (SNB) to Dx vasculitis? Study of 91 pts undergoing SNB suggests the SNB must be off sufficient length to improve Dx yield. 40/91 (44%) showed vasculitis. +SNB assoc w/ longer SNB sample, other organ Sxs & +ANCA https://t.co/6S00ySj0fL https://t.co/WbY400YsWX
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Dr. John Cush RheumNow ( View Tweet)