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RA-ILD in the Spotlight at ACR 2024

Jeffrey Sparks, MD, MMSc

Over the past 5 years, there has been growing interest in RA-ILD due to its relative prevalence and severity. This seems to be one of the few RA outcomes not improving much, even with the advent of expanded treatment options. There is also a shocking lack of trial data. This year, there were two oral sessions dedicated to RA-ILD, one of which even the overflow room was standing room only, in addition to many posters.

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Novel and Emerging Therapies in Psoriatic Arthritis

Antoni Chan, MD, PhD

Recent advancements in targeted therapies, including selective inhibitors of key inflammatory pathways, offer promising outcomes for patients with active psoriatic arthritis (PsA). At ACR 2024, there have been further developments in novel therapies in PsA.

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men and women

Sex related differences in PsA

Adela Castro, MD

Different factors are known to influence disease characteristics and outcomes in psoriatic arthritis (PsA).

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Novel and Emerging Therapies in Psoriatic Arthritis Recent advancements in targeted therapies, including selective inhibitors of key inflammatory pathways, offer promising outcomes for patients with active psoriatic arthritis (PsA). At ACR 2024, there have been further… https://t.co/vBexcBrTQ6 https://t.co/gWpIYKMPnx
Dr. John Cush RheumNow ( View Tweet)
SELECTing the right patients: upadacitinib in GCA Dr. Brian Jaros reports on abstract 1695, presented at #ACR24. https://t.co/x8lLTviOKk https://t.co/yXwwrdgIyu

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Dr. John Cush RheumNow ( View Tweet)
How New Medications are Reframing Imaging Abnormalities in axSpA Bimekizumab (BKZ), a monoclonal antibody targeting IL-17A and IL-17F, was evaluated in the BE MOBILE 1 and 2 trials for non-radiographic and radiographic axSpA, respectively. It showed significant clinical… https://t.co/wJYh5XCVfw https://t.co/qZ2MnGVXXG
Dr. John Cush RheumNow ( View Tweet)
💊Litifilimab- another new molecule for SLE Anti BDCA2 🎯 In cutaneous lupus👉 👉Decrease CLASI score 👉Decrease IFN induced MxA expression #ACR2024 #ACRAmbassador https://t.co/AeJOGhVXIR

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Ritasman Baisya RitasmanB ( View Tweet)
SELECT-GCA: Efficacy and Safety of Upadacitinib Dr. Richard Conway discusses abstract 0770, presented at #ACR24 https://t.co/C9HZIMP9JK https://t.co/zVhFAfLBQe

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Dr. John Cush RheumNow ( View Tweet)
JAK inhibitors in GCA? We have a phase 3 trial in giant cell arteritis back on the opening day plenary stage. The SELECT-GCA study, looking at upadacitinib in GCA, was scheduled to anchor the #ACR24 opening plenary for a reason - it is highly notable and badly needed.… https://t.co/aJ3uao1wD7 https://t.co/6ao2OoODHg
Dr. John Cush RheumNow ( View Tweet)
GLP-1 Agonists Show Promise in Slowing Kidney Disease in Lupus Nephritis Glucagon-like peptide-1 receptor agonists (GLP-1Ra) have transformed the treatment landscape for type 2 diabetes and obesity. #ACR24 https://t.co/6QqEH8X2VJ https://t.co/Ch2i9zZYii

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Dr. John Cush RheumNow ( View Tweet)

JAKi in inflammatory myositis? #ACR24 will showcase nearly 3000 abstracts. With the expanding use of JAK inhibitors, there will be some interesting presentations for off label use. There have been some uncontrolled data that tofacitinib reduced inflammatory myositis disease… https://t.co/SnqvElwk0B https://t.co/A5mJbpmB5P

Dr. John Cush RheumNow ( View Tweet)
Finding the Right Combination Therapy in RA Dr. Jonathan Kay interviews Dr. Ernest Choy about abstract 0521, Transcriptome Analysis of Drug Response in a Large Cohort of Immune-Mediated Inflammatory Disease Patients Supports Advanced Combination Therapy in RA, presented at… https://t.co/yPmDIZ6aKI https://t.co/cairKrbDDu
Dr. John Cush RheumNow ( View Tweet)
#Ianalumab 300 mg sc q monthly B cell depleted and changes BAFF signalling 👇⬇️IFN May be promising in #lupus #SLE +data in primary #Sjogrens ACR24 @RheumNow @ACRheum Abst#2425 Needs Phase3 ➡️I suspect safer than CAR T and Bispecific T cell engagers but ? ⬇️efficacy

Janet Pope Janetbirdope ( View Tweet)

ACR24 take homes ➡️#Inflammatory #myositis #Upadacitinib improved MDA5 ILD #Baricitinib 4mg/d good in myositis delayed start #RCT #Tofacitinb ➡️help for skin, calcinosis, rash in case series ➡️RCT ongoing JAKi is ‘jacked’ in muscles 💪🏿 #ACR24 @RheumNow @ACRheum 1731 0348

Janet Pope Janetbirdope ( View Tweet)

Late breaking abstract L17 CAR-NK Therapy for Refractory SLE. In a trial of 20 severe SLE patients: - 75% achieved LLDAS, 50% achieved DORIS remission at 6 months - B cell reconstitution: 2–3 months post-treatment - Safety: 2 mild cytokine release syndrome with fever; no severe… https://t.co/MS8cutm48o

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Antoni Chan MD (Prof) synovialjoints ( View Tweet)

In Vivo CAR T Cell Therapy. A single intralymphatic injection of VivoVec™ particles: - Generates functional CAR T cells in vivo - Achieves complete B cell depletion in NHPs without lymphodepletion - Demonstrates potential for an off-the-shelf solution for autoimmune disease… https://t.co/5DTzRvZjbY https://t.co/DvTOqnhn1V

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Antoni Chan MD (Prof) synovialjoints ( View Tweet)
🚨 New SLE treatment update! 🚨 Dapirolizumab pegol (DZP), novel CD40L inhibitor, for moderate-to-severe lupus. Phase 3 trial, DZP reduced disease activity, helped taper steroids, and achieved a higher BICLA Safe and generally well tolerated! #ACR24 #L16 @rheumnow https://t.co/lFrKjz4CZ1

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Bella Mehta bella_mehta ( View Tweet)
Hydralazine - known culprit of drug-induced AAV How does hydral (H) AAV differ from primary (1) AAV? 💥 High dual positivity MPO/PR3 💥 DAH / pleuritis more common in H-AAV 💥 ENT, constitutional, nervous, ILD in 1-AAV 💥 More 6mo remission in H-AAV @rheumnow #ACR24 Abst 2496

Brian Jaros, MD Dr_Brian_MD ( View Tweet)

In prelim analysis of this controlled clinical trial, SLE pts w/ active dse who weres given addtl NAC for 3 mos had significantly reduced dse activity. Mechanism? NAC reduces rapamycin (mTOR) activation. Common AEs: nausea, vomiting @RheumNow #ACR24 abs2677 https://t.co/E4w2Qd7RwP

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sheila RHEUMarampa ( View Tweet)
In the AMPLIFIED study (phase 3, single-blind RCT) ABA not superior to ADA in patients with dual seropositive early RA and HLA Class II #ACR24 @RheumNow ABST#2671 https://t.co/VSorAiJUIe

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Jiha Lee JihaRheum ( View Tweet)
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