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New 5 Peptide Autoantibody Panel Complements RA Diagnosis
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MedPage Today
Antibodies to peptides not currently used for rheumatoid arthritis (RA) diagnosis helped identify patients with untreated early disease that conventional biomarkers missed, researchers said.
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GRAPPA Recommendations for Treating Enthesitis in Psoriatic Arthritis
GRAPPA has provided new, evidence based updates to the management of enthesitis in patients with psoriatic arthritis (PsA), affecting at least 30% of PsA patients and is associated with more severe disease, x-ray damage, and poorer outcomes.
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ICYMI: GRAPPA Recommendations for Treating Enthesitis in Psoriatic Arthritis
GRAPPA has provided new, evidence based updates to the management of enthesitis in patients with psoriatic arthritis (PsA), affecting at least 30% of PsA patients and is associated with more severe disease, x-ray damage, and poorer outcomes.
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ChatGPT - A Boon or Threat to Scientific Publication?
ChatGPT is a new, artificial intelligence chatbot that has dramatically changed the digital worlds of education, research, graphic design, statistics and more.
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ChatGPT - A Boom or Threat to Scientific Publication?
ChatGPT is a new, AI chatbot that has dramatically changed the digital worlds of education, research, statistics and more.
Recently there were reports of ChatGPT passing the LSAT, USMLE, and more.
https://t.co/CZd0WjOas5 https://t.co/Nx49SqXoHG
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Dr. John Cush RheumNow ( View Tweet)
High- Versus Low-Dose Exercise Therapy for Knee Osteoarthritis
The Annals of Internal medicine has reported the results of high-dose versus low-dose exercise therapy demonstrating no benefits from more intense exercise.
https://t.co/BtqeYWKG34 https://t.co/ngyM1DshDz
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Dr. John Cush RheumNow ( View Tweet)
Multicenter study of 80 AOSD & 60 controls used to develop AOSD criteria:
- 3 pts rash
- 3pts fever ≥ 39C
- 2 pts pharyngitis
- 2 pts arthritis
- 2 pts NLR ≥ 4
- 1 pt glycosyl ferritin ≤ 20%
7 pts = Dx (sens 92.5%) vs Yamaguchi(79%), Fautrel (76%) https://t.co/Amew1RHaA1 https://t.co/dnJ6zVyfOW
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Dr. John Cush RheumNow ( View Tweet)
Full read, solid review of Diagnosis and management of autoimmune hepatitis from BMJ https://t.co/9OdxHjXMKW https://t.co/1kuHPZBLSE
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Dr. John Cush RheumNow ( View Tweet)
Pregnancy & RA: metanalysis of 9 studies, 12K RA pts met vs 10 million controls. RA preg have more maternal complications (C sect OR 1.55; preeclampsia OR, 1.6; preterm OR, 1.8) & neonatal probs (low gestat wt, ICU OR 1.34, & stillbirths OR, 1.99). https://t.co/30WTMC3MKn https://t.co/VXoHesd3iT
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Dr. John Cush RheumNow ( View Tweet)
Univ of Toronto’s PsA Study looked at surgery amongst 1574 pts: 185 pts (~12%) had 379 MSK surgeries related to PsA. Signif higher rates of surgery were seen w/ #damaged joints (HR 1.03), TJC/SJC (HR 1.04), nail Dz (2.08), ^ ESR (2.37), B27+ (2.22) https://t.co/XdUJ0guwUh
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Frailty in Vasculitis
Dr. Patricia Harkins sits down with Professor Sebastian Sattui to discuss Abstract 0444, Prevalence of Frailty and Associated Factors in Patients with Vasculitis, being presented on at the ACR22 Convergence.
https://t.co/u0CZuEcyM9 https://t.co/JXEcSoHsA2
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Dr. John Cush RheumNow ( View Tweet)
New Guideline: Vaccinations OK With Few Tweaks for Rheum Patients
Nearly all available vaccines can be given to people with rheumatologic diseases, according to a new, detailed guideline from the ACR.
https://t.co/514mIylgzj https://t.co/9Zq9pGcujV
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Dr. John Cush RheumNow ( View Tweet)
Have a rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology.
https://t.co/TampvCiCIs https://t.co/y9FDVJoEaD
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Dr. John Cush RheumNow ( View Tweet)
Metanalysis of Steroid Tx & metabolic events (118 studies & 17113 pts) showed an increased risk:
- hyperglycemia 10% (esp lung dz 22%)
- severe hyperglyc. 5%, HTN 6%, Wt gain 13% , hyperlipid 8%
- Incr risk of hyperglyc(OR 2), HTN (1.7), Wt gain (5.2) https://t.co/E54IB3YVfn https://t.co/CPzrgIgJ12
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Dr. John Cush RheumNow ( View Tweet)
Full read, very good review of steroids, HPA suppression, equivalents, use during surgery etc from J Endo Society. Notably literature supports continued daily GC in surgical patients, with a short course of perioperative IV GC https://t.co/jzNE5o0DBG https://t.co/6V8mhTOVTv
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Dr. John Cush RheumNow ( View Tweet)
About 1 mo ago we reported US drug makers would increase price of 350 drugs; now it seems US Pharma has raised list prices of 983 arthritis, cancer and otherdrugs by an average of 5.6% in Jan 2023; as industry faces new federal laws to control costs https://t.co/HkdDurbNrQ https://t.co/rEvmwACdfk
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Dr. John Cush RheumNow ( View Tweet)
Early ph II Pilot trial of 30 Systemic Sclerosis Pts using a new antifibrotic FT011 400mg vs 200mg v PBO x 12 wks showed CRISS score improved by 60% (400mg; (p=0.02 ) or 20% (200mg) at 12wks. An OL extension is planned for 9 mos @400 mg/d. https://t.co/8R51VLUbvX https://t.co/vc3JJKXfk3
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Dr. John Cush RheumNow ( View Tweet)
Novel Proteomic Biomarker Set in Osteoarthritis
NIH funded researchers have developed a set of serum proteomic biomarkers that successfully predict clinically relevant KOA progression (both structural change and joint pain) over a 2 year period.
https://t.co/4xU2bYS0xN https://t.co/Rtdr280ghe
Links:
Dr. John Cush RheumNow ( View Tweet)
Physician Burnout Remains, Less So in Rheumatology
The 2023 Medscape Survey on Physician burnout ranks rheumatology at #10; which is down from #2 when the survey was last done in 2021.
https://t.co/IsC8TQ95RH https://t.co/BBQaSUnQoj
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Dr. John Cush RheumNow ( View Tweet)
1st there was combined Rheum-Derm or Rheum-Pulm clinics. Medscape reports new Rheum-Cardiology clinics at Cleveland Clinic, NYU, Brigham, Stanford. Useful in research, managing Rheum pts a) at hi CV risk, B) having procedures/surgery, c) risk reduction https://t.co/Y5KDv7wSho https://t.co/WjHVxOQ1xJ
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Dr. John Cush RheumNow ( View Tweet)
