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ACR Fellow Training Subcommittee Report on Pandemic Experiences
Arthritis & Rheumatology has publish an ACR Subcommittee report on how the COVID-19 pandemic affected fellows and their training.
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Is Alzheimer's Risk Lower With TNF Inhibitors?
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MedPage Today
Tumor necrosis factor (TNF) inhibitors for rheumatoid arthritis were linked with a lower risk of Alzheimer's disease and related dementia, but only in people with cardiovascular disease, data from the DREAM (Drug Repurposing for Effective Alzheimer's Medicines) study showed.
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How long does a good response last to a biologic?
How and When to distinguish between flares and intercurrent illness.
QD Clinic is sponsored by RheumNow's PsA All the Way Campaign in April 2022
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SLE study from BC, Canada shows that among 3062 incident #SLE patients 96% received antimalarial (AM) Rx with only 40% adherent. Over a 6.4 yr F/U, 242 (8%) died. AM adherence was assoc w/ a 71% and 83% lower risk of death https://t.co/S9LsDaSZNx https://t.co/lFWZJTh367
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Ixekizumab in 1401 #PSA pts w/ 2248 Pt-Yrs exposure showed Serious AE in 134 pts. Most common AEs were nasopharyngitis & URI. Incidence of SAE (≤1.2/100PY), cancer (0.7/100PY), IBD (0.1/00PY), depression (1.6/100PY) were low. #PSAlways https://t.co/YGGj4XCQDM
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Retrospective study of 1144 consecutive inflammatory myositis (IIM) pts shows a 2.3% risk of venous thrombolic events. 54% of VTE occurred within 6 mos of IIM Dx. Predictors included malignancy, infection, longer steroid use , higher Dz activity https://t.co/DCH4Iuy2FS https://t.co/uNc6i6L7JJ
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Cell has a novel analysis using single-cell analysis of skin/blood from 56 controls & 97 diffuse systemic sclerosis pts, finding stromal abnormalities in LGR5+-scleroderma-assoc fibroblasts (ScAFs). ScAFs are decreased early & progressively https://t.co/Khxejd1fnq https://t.co/OrMAJnPTZt
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Dr. John Cush RheumNow ( View Tweet)
ArthritisPower study of 332 #PsA pts finds patients are most bothered by joint pain, MSK pain & fatigue. Patients prefer oral, QD meds; 3/4 want Rx that improved joints vs skin; and would prefer to avoid MTX https://t.co/WYqWgoimOT https://t.co/RgGeCKrpT1
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2020 Pt preferences survey- 137 #PsA pts most took TNFi (30%), IL-17i (20%), MTX (10%). From 2018 to 2020 a signif incr in IL-17i & PDE4 inhib. Pts want Rx for damage (80%), ADL (71%), & pain (70%) https://t.co/2dyIuQubh5 https://t.co/sFbtRj0Lbv
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ICYMI: Deucravacitinib, TYK2 inhib, studied in phase II trial 203 active PsA pts randomised to PBO, or DEUC 6 mg or 12 mg qd. At wk 16 ACR-20 responses were significantly higher with DEUC 6mg (53%, p=0.0134) and 12 mg (63%, p=0.0004) vs PBO. https://t.co/UOPteZY0g8 https://t.co/Xw3ZSPWeE0
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ICYMI: Differences between Palpated & Ultrasound Joint exams in 155 #PSA patients. 5616 joints - found 18.5% tender, 9.8% swollen, 20.4% w/ US GS ≥ 2 and 5.2% had US PD ≥ 1. Joints that were both tender and swollen more likely to have GS ≥ (44%) https://t.co/M6y5Gezhjs https://t.co/HYoI3pExRm
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ICYMI:The Enthesitis Challenge in Psoriatic Arthritis
A colleague of mine told me an interesting story about how her father, who was a doctor, misdiagnosed his wife with fibromyalgia when she actually had PsA with enthesitis all along.
Read more...
https://t.co/bSYdtlL41J https://t.co/gKKdWTvyMB
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ICYMI: TNR Recap: What Patients Say About PsA
Watch Tuesday Nite Rheumatology, held on 4/5/22,which featured a Patient Perspectives panel discussion, hosted by Dr. Jack Cush.
PsA Panelists included:
- Tena Brown
- Christine Lindsay
- Ashley Krivohlavek
https://t.co/FyjnzrtKqp https://t.co/uEHsoAwHLY
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ICYMI: Dactylitis Indicates a Severe PsA Phenotype
https://t.co/7VVoc0f1Ap https://t.co/uZxfqLvtcp
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ICYMI: 520 RA pts were screened with FibroScan (liver fibrosis)- F3 or F4 liver fibrosis seen 13.3% of controls vs 12.7% arthritis pts. MTX was not significantly correlated w/ higher FS scores. Liver stiffness was correlated w/ BMI, waist, male , age. https://t.co/PxrabHROPy https://t.co/UAw51Hb5vU
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Humbled to lecture at the #StaabSymposium with rheum greats @RheumNow and @KeithReich3 https://t.co/RHM1oneIc3
TheDaoIndex KDAO2011 ( View Tweet)
What I learned... always get an ALP and phosphorus level in people with chronic bony pain. https://t.co/nE0xYwODmC
TheDaoIndex KDAO2011 ( View Tweet)
Useful TST (PPD)/IGRA interpreter website for TB testing. A 31 yoM Texan w/ +IGRA only (true pos) has risk of active TB & INH hepatitis 0.1% & 0.4%. But if this was 60 yoF from Iraq on TNFi & pred the same risks are 20% & 2.3% https://t.co/M18cHuLrXu https://t.co/zIoFY4abXN
Dr. John Cush RheumNow ( View Tweet)
ICYMI: Metanlysis of psychological interventions for chronic low back pain (97 RCTs, 13,136 pts) finds that Only behavioural therapy delivered w/ physiotherapy care (mainly structured exercise) reduced pain intensity up (high quality evidence) https://t.co/56pMRVk0ic https://t.co/wxcfninf14
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ICYMI: Review of 5 trials shows ixekizumab with higher rates of complete skin & nail clearance compared H2H against to etanercept, guselkumab, ustekinumab, and adalimumab (Data from IXORA-R, IXORA-S, UNCOVER-2, UNCOVER-3, & SPIRIT-H2H trials https://t.co/t5wrmE3nbK #PsA #PsAlways https://t.co/MQjgktOZWR
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Dr. John Cush RheumNow ( View Tweet)