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Other data on TNF and pregnancy!
To maintain pregnancy and avoid complications , decrease inflammation! how? by continuing TNF!
▶️No increase risk of infection or vaccination response.
@UmaMahadevanIBD @RheumNow #Rnl2022 https://t.co/mcEMDzNlyH
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
What about live vaccines?! is there any increase risk of complications ?!
@UmaMahadevanIBD @RheumNow #Rnl2022 https://t.co/x74RoWNnLc
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Pregnancy and Biologics
@UmaMahadevanIBD sharing excellent information on how stopping drugs can lead to more harm:
Lacking data that RA improves during pregnancy
Provider bias?
Steroids can increase complications in pregnancy
@RheumNow #RNL2022 https://t.co/jtCnD4wTag
Robert B Chao, MD doctorRBC ( View Tweet)
And finally, Day 1 will close out with POD 4: Spondyloarthritis Spectrum at 5pm ET. Join Dr. Philip Mease at his presentation on Axial Psoriatic Arthritis. #RNL2022 https://t.co/TInpHYteOx
Dr. John Cush RheumNow ( View Tweet)
#ClinicalPearl #Lupus nephritis is often now START w 2 immune suppressive & less total dose of #prednisone & May pulse w 500 mg solumedrol x3 instead of 1g. J Merrill #RNL2022 @RheumNow https://t.co/ePKkPHWhYJ
Janet Pope Janetbirdope ( View Tweet)
#ClinicalPearl Most ordering HCPs don’t know which #ANA is being performed when you order it. Lots of variability. Bottom line IF you DON’T have > moderate risk of #CTD DON’T order it. The FALSE + results will haunt your pt & you & cost 💰#RNL2022 @RheumNow https://t.co/uxMbAdOKcj
Janet Pope Janetbirdope ( View Tweet)
Why do we love to hate #guidelines in #rheumatology - maybe for example in #PsA we really don’t know the BEST Rxas 1st line advanced therapy & beyond. I say: Take a guess or do a pragmatic trial to figure it out. A Kavanaugh #RNL2022 @RheumNow https://t.co/lVIno6FBqJ
Janet Pope Janetbirdope ( View Tweet)
#RNL2022 Drs. Kavanaugh, Ogdie and Kirkham join Dr. Cush for the PsA panel Q & A. https://t.co/0ElGIe21S6
Dr. John Cush RheumNow ( View Tweet)
Cellular source of IL17 in SpA
Bruce Kirkham @RheumNow #Rnl2022 https://t.co/vDMks0RtBb
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Synergetic effect of IL17 and TNF in PSA.
Bruce Kirkham @RheumNow #Rnl2022 https://t.co/acfqiluJWR
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Dr. Bruce Kirkham
Drug Targeting in Psoriatic Arthritis
SEAM PsA study - MTX monotherapy not AS efficacious as MTX and TNFi combo therapy, but STILL effective
@RheumNow #RNL2022 https://t.co/qsSGgD9bq7
Robert B Chao, MD doctorRBC ( View Tweet)
Dr. B. Kirkman reviews research and development timeline for IL17A. I've started explaining this trajectory to patients when discussing "newer" drugs to market that have been around since I was in elementary school. #RNL2022 @RheumNow https://t.co/TgaOYmkBO4
Dr. Rachel Tate uptoTate ( View Tweet)
Dr. Kirkman reviews IL12, IL23, and IL17s. #RNL2022 @RheumNow https://t.co/nFHBzrdz2D
Dr. Rachel Tate uptoTate ( View Tweet)
Excellent graphic on mechanisms of action of PsA and their effects on specific cytokines
@RheumNow #RNL2022 https://t.co/B0ZT6qlpbE
Robert B Chao, MD doctorRBC ( View Tweet)
Use questionnaire if you sense something is not right!!
Bruce Kirkham @RheumNow #Rnl2022 https://t.co/tuBZiA7Dqf
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
T rm cells
▶️Found in skin and joint.
▶️Found in skin and Joint
▶️Unregulated easily in case of inflammation
▶️Releases IL17
▶️Specific role in PSA
Bruce Kirkham @RheumNow #Rnl2022 https://t.co/apFXhzIpFo
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
We always want Real World Data (RWD) but where does this come from? Dr. @AlexisOgdie reviews RWD and RWE (evidence) which "ideally reflects patients we actually see in clinic." #RNL2022 @RheumNow https://t.co/KLJlQ6wzqC
Dr. Rachel Tate uptoTate ( View Tweet)
Enthesitis in PsA is multi-faceted.
Environmental triggers, microbiome, microdamage in combination with innate immune response in genetically susceptible patients can active the IL-23 and IL-17 pathway
Leading to cartilage damage and degradation
@RheumNow #RNL2022 https://t.co/hvkCmJ0V1S
Robert B Chao, MD doctorRBC ( View Tweet)
PSA management:
MTX can be used alone
TNF and MTX are more effective
Other agents
Bruce Kirkham @RheumNow #Rnl2022 https://t.co/rgdylgYDSb
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Get the skinny on THIN. Large EMR database in UK with real world evidence #RWE in #PsA. #Psoriatic arthritis. Teaches about safety, drug retention & comparative effectiveness. Latter is a problem as loss of retention could be ineffective, side effects A Ogdie #RNL2022 @RheumNow https://t.co/V1mYiE3GbI
Janet Pope Janetbirdope ( View Tweet)