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Lupus,flare,malar,DermNetNZ

Increased SLE Flares with Hydroxychloroquine Reduction

d Jack Cush, MD

Concerns about the long-term safety of hydroxychloroquine (HCQ) often results in dose reduction or drug discontinuation; yet a current study shows that, for those in remission, HCQ taper/discontinuation resulted in a significantly higher rate of SLE flares.

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knee.surg2_.jpg (keep)

Updated ACR/AAHKS Guidelines on Drug Use in Knee & Hip Arthroplasty Patients

d ACR

The American College of Rheumatology and the American Association of Hip and Knee Surgeons released a summary of their updated guideline for the Perioperative Management of Antirheumatic Medication in Patients with Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty.

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Vaccination,vaccine

Downside of Holding Methotrexate with COVID-19 Vaccination

d Jack Cush, MD

A recent prospective, randomized, blinded clinical trial has shown that a 2 week hold of methotrexate (MTX) following COVID-19 (Sinovac-CoronaVac) vaccination resulted in greater anti-SARS-CoV-2 immunogenicity; but there was an increase in flare rates after the second dose of vaccine.

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Retrospective study of juvenile dermatomyositis shows 1st line Rx w/ MTX is not effective, esp in MSA Ab+ pts. 45 JDM pts (2/3 severe) Rx w/ 6 mos MTX + steroids; inactive dz seen in 31%, with 42% muscle and 33% skin responses. MSA neg pts did better https://t.co/PDubjbcMe2 https://t.co/rGCSZ3ZT9U

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Dr. John Cush RheumNow ( View Tweet)
Referring Psoriasis with Joint Pain Psoriasis Patient with a Few Tender Joints - How to Refer to a Rheumatologist. QD Clinic is sponsored by RheumNow Live (March 19 & 20, 2022 in Las Colinas, Texas) https://t.co/kuDc6xi3NZ https://t.co/VCFFFqA040

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Dr. John Cush RheumNow ( View Tweet)
Psoriatic fingernail onycholysis and hyperkeratosis, rather than nail pitting, are significantly & independently assoc w/ PsA. Study of 1985 pts w/psoriasis, 11.5% were Dx w/ PsA. Only onycholysis (OR 2.34) and hyperkeratosis ) were assoc w/ PsA https://t.co/X3JHUFtGdD https://t.co/xu8erkOMSa

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Dr. John Cush RheumNow ( View Tweet)
Health Disparities in Rheumatology - a great lecture by Dr. Alvin Wells at RWCS 2022. https://t.co/aZXrKndenF

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Dr. John Cush RheumNow ( View Tweet)

Updated ACR/AAHKS Guidelines on Drug Use in Knee & Hip Arthroplasty Patients https://t.co/e6hSUJDrLK https://t.co/DzgCm47Qyh

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Dr. John Cush RheumNow ( View Tweet)
Downside of Holding MTX with COVID-19 Vax A recent clinical trial has shown that a 2 week hold of MTX following COVID-19 vax resulted in greater anti-SARS-CoV-2 immunogenicity; but there was an increase in flare rates after the second dose of vaccine. https://t.co/a7XfBxVkvJ https://t.co/h4VqsQYkaK

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Dr. John Cush RheumNow ( View Tweet)
Undifferentiated Arthritis +RF Arthralgias x 3 mos and a vague Family History of arthritis. How would you treat? QD Clinic is sponsored by https://t.co/4UQlqwujiR (March 19 & 20, 2022 in Las Colinas, Texas) https://t.co/O0KywLk5dd https://t.co/JV37SGk7ud

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Dr. John Cush RheumNow ( View Tweet)
CRP! Dr John Reveilles review of potential biomarkers in axial spondyloarthritis, includes cytokines, adipokines, MMPs, calprotectin, CD74, bone turnover markers & protein fragments of cartilage degradation - But none can outperform C-reactive protein https://t.co/pmIDZkuOuP

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Dr. John Cush RheumNow ( View Tweet)

🎯Giant cell tumor 🎯denosumab was used to decrease the stage of the local disease prior to surgical resection in 57% of patients #RheumTwitter #Rheumatology #Rheumato #denosumab https://t.co/CBfW3gPvFV https://t.co/pEvo4jUnBH

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Dr.Hala Fadhil MD drhalafadhil ( View Tweet)
Today is RARE DISEASE DAY Retweet 🔄 to raise awareness of rare #autoimmune diseases such as #Lupus https://t.co/EfjOfvNh1h
Laurent ARNAUD Lupusreference ( View Tweet)
Drug Safety Advisories from regulators appears to reduce physician prescribing by 5.8%. Data from a study of 2 dozen advisories in 4 countries, Canada, Denmark, US, and UK between 2009 and 2015. https://t.co/TB6IeH9eGS https://t.co/2BiJJqQfSQ https://t.co/H3xuzyPJNX

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Dr. John Cush RheumNow ( View Tweet)
Deaths due to non-benzodiazepine hypnotics and gabapentinoids increased significantly over the last two decades. Clinicians should not assume that replacing benzodiazepines and opioids with these medications necessarily lowers risk to the patient. https://t.co/hfwKElpdFc https://t.co/lgHyRv7OyQ

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Dr. John Cush RheumNow ( View Tweet)
Medicines 10 Lowest Hourly Wages 1 FP $89/hr 2. Int Med $90 3 ID $92 4 Peds $94 5 Endo $100 6 Rheum $102 7 Prevent $105 8 Allergy $112 9 Neuro $114 10 Psych $117 https://t.co/EFTNYTUOgA https://t.co/wjcbC6dLML

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Dr. John Cush RheumNow ( View Tweet)
Acute onset swelling in but a few joints. What's a hairdresser to do? What would you do? QD Clinic is sponsored by https://t.co/4UQlqwujiR (March 19 & 20, 2022 in Las Colinas, Texas) https://t.co/KYI05R1h5J https://t.co/GobpZ4TRhQ

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Dr. John Cush RheumNow ( View Tweet)
Listen in… Fellow Case Presentations From RWCS 2022 https://t.co/SvaGfyDDTK https://t.co/MP9iWQK8ZB

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Dr. John Cush RheumNow ( View Tweet)
Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow. This week, rheumatologic problems incited by respiratory infections, air pollution and how you live, now where you live. Download wherever you get your podcasts. https://t.co/AR08F92XSY https://t.co/sqqlHvSHUL

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Prevent NSAID GI bleeding or perforation? Korean study (n=92K) shows (vs non-prophylaxis) PPI and COX-2 inhibitors associated with 64% and 74% reduced risk. COX2 = PPI +nsNSAID. H2-receptor antag. did not reduce the risk https://t.co/pUuVzwiQgx https://t.co/JAUqW9AMck

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Dr. John Cush RheumNow ( View Tweet)

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