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Combo MTX and Leflunomide in Psoriatic Arthritis

d Jack Cush, MD

A recent study has shown that the combination of methotrexate (MTX) plus leflunomide (LEF) yields better disease control in psoriatic arthritis, but may not be as well tolerated as monotherapy with MTX.

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Baricitinib’s COVID-19 Efficacy in the RECOVERY Trial

d Jack Cush, MD

Pre-print results of the RECOVERY Trial has shown that when baricitinib (BAR) is given to hospitalized severe COVID-19 patients, it results in significantly less mortality.

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Failed Osteoarthritis Pulse Ultrasound Study

d MedPage Today

A promising therapy aimed at halting and even reversing the pathology underlying osteoarthritis (OA) of the knee failed to show any benefit in a randomized trial.

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Ethnic and Behavioral Drivers of Gout Risk

d Jack Cush, MD

Gout is common but disproportionately affects certain groups (e.g., the elderly, Pacific Islander, Blacks). Ethnic links to gouts were also shown to be linked to modifiable behavioral factors and such information maybe useful in managing gout patients.

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Undifferentiated Arthritis Does Not Follow an RA Course

d Jack Cush, MD

Undifferentiated arthritis (UA) is common in medical practice and many advocate early use of DMARDs; yet a recent study shows that despite DMARD use, UA patients do not fair well with this approach.

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Single center study of individualized anakinra use in 47 autoinflammatory pts (32kids; 43% MAS; 40% systemic JIA). Off-label use in 38%, higher doses in 21 kids (5-29mg/kg); & 5 given IV anakinra; such doses were well tolerated without major AE. https://t.co/wQgw3YAPKX https://t.co/zL3HfdX4Ns

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Dr. John Cush RheumNow ( View Tweet)
Juvenile CADM: JAMA Case - 6 yoF with 4 yrs of rash on hands, feet, elbows, knees. No Resp to topicals. ROS rare cough & SOB; no weakness. Gottrons over hands, knee. Bx +, ANA+ 1:320, nl enzymes, MSA- See how she was Rx https://t.co/l26Y666JKZ https://t.co/XlzWNKILJU

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Dr. John Cush RheumNow ( View Tweet)
Good review of Diagnosis and Treatment of Pulmonary Sarcoidosis in JAMA. - Lung progression (in only 10%) assoc w/ 12-18% 5yr mortality - Sx Sarcoid w/ Lung: start Pred 20 to 40 mg/d for 2 -6 wks - Steroid sparing w/ MTX, AZA or TNFi https://t.co/ylF8KR47gc https://t.co/VUvjYYC8gG

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Dr. John Cush RheumNow ( View Tweet)
Shared Decision Making in PsA Changing to a new biologic or sticking with the old one - a PsA patient chooses QD Clinic is sponsored by https://t.co/4UQlqwujiR (March 19 & 20, 2022 in Las Colinas, Texas) https://t.co/Hc7ctWtj7A https://t.co/BAApPkxefc

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Dr. John Cush RheumNow ( View Tweet)
We are excited to announce that Dr. Philip Mease will be joining us at RheumNow Live, leading a presentation and discussion on Axial Psoriatic Arthritis & Fatigue and Central Sensitization. Join the discussion on March 19-20, on site or virtually! https://t.co/AIteIEHY9E https://t.co/ybXhIelSgM

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Dr. John Cush RheumNow ( View Tweet)
Gout is common but disproportionately affects certain groups (e.g., the elderly, Pacific Islander, Blacks). Ethnic links to gout were also recently shown to be linked to modifiable behavioral factors that may prove useful in managing gout patients. https://t.co/uvIuw3zFnq https://t.co/EZomBGQIyt

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Dr. John Cush RheumNow ( View Tweet)
Study of 155 adult patients (PsA 61/AS 94) looked at labs & CV risk factors; found IL-18 elevated in peripheral PsA more than axial PsA & AS. Elevations were higher in PsA pts w/ ischemic heart disease correlated w/ atherogenic index & TG levels https://t.co/PQ3fBi8Qdo https://t.co/mewrcwhi4o

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Dr. John Cush RheumNow ( View Tweet)
Another Kind of COVID Discussion Another kind of COVID (vaccination) discussion - kindness and respect for the patient QD Clinic is sponsored by https://t.co/4UQlqwujiR (March 19 & 20, 2022 in Las Colinas, Texas) https://t.co/XkUkqQ1Vli https://t.co/lrPd6jBMjt

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Dr. John Cush RheumNow ( View Tweet)
Tocilizumab Works Best in Non-Mechanical Ventilated COVID-19 Patients https://t.co/nUrAikqyPS https://t.co/CfmyB7Wwb6

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Dr. John Cush RheumNow ( View Tweet)
Download this week’s podcast titled “When Less (Drug) is More (Activity) “ https://t.co/omdC3fElsb https://t.co/Hva4h9yEa9

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Dr. John Cush RheumNow ( View Tweet)
ACR Guidelines for the Treatment of Systemic Juvenile Idiopathic Arthritis The ACR has updated its clinical guidelines for the management of JIA, with this update focusing on oligoarthritis, TMJ arthritis, and systemic JIA. https://t.co/eKv8qubl1v https://t.co/xLBMccCYex

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Dr. John Cush RheumNow ( View Tweet)
COMPLETE-PsA Trial studied MTX vs MTX + leflunomide in 78 active untreated PsA pts. MTX+LEF was superior to MTX alone at wk 16 (PASDAS 3·1 vs 3·7; p=0·025). Combo group had more N/V (44% v 28%), ^ALT (31% vs 18%). https://t.co/Hc4rNrlQzP https://t.co/UPosZIc4C0

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Dr. John Cush RheumNow ( View Tweet)
Drug Survival Differences in RA, PsA, SpA and PsO https://t.co/aBRhTbVmCM https://t.co/ZDGiKlowoV

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Dr. John Cush RheumNow ( View Tweet)
Rheumatoid Arthritis and Eosinophilia Considerations when eosinophilia is seen in RA patients. QD Clinic is sponsored by https://t.co/4UQlqwujiR (March 19 & 20, 2022 in Las Colinas, Texas) https://t.co/2FszCiTLgf https://t.co/07uZT2heW3

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Dr. John Cush RheumNow ( View Tweet)
New Download Available! Autoimmune Disease in the USA https://t.co/KvsgBUY7mL https://t.co/PSTF7ma6G6

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Dr. John Cush RheumNow ( View Tweet)
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