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Predicting Treatment Response in Inflammatory Muscle Disorders

d MedPage Today

Rheumatologists looking for clues to whether their patients with certain inflammatory myopathies will improve on immunosuppressive drugs may find them in a new study appearing in Arthritis Care & Research.

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RA Hands Difficult deformity

BMI Most Impairs Treatment Response in Rheumatoid Arthritis

d Jack Cush, MD

Using a large cohort of rheumatoid arthritis (RA) patients, Tumor-Necrosis Factor inhibitors (TNFi) were compared to non-TNFi biologic therapies and showed that poorer responses were seen in obese and underweight patients, with no clear superiority of non-TNFi therapy over TNFi therapy in an

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PsA, PSO, nail

Two Year Guselkumab Benefits in Psoriatic Arthritis

d MedPage Today

Patients enrolled in one of the pivotal trials of guselkumab (Tremfya) as therapy for psoriatic arthritis (PsA) and followed for 100 weeks continued to show significantly reduced symptoms relative to pretreatment baseline, researchers said.

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Many failed clinical trials in Scleroderma in the past. #RWCS2022 @RWCSmtg https://t.co/2PBfHAnqWu
Dr. John Cush RheumNow ( View Tweet)
Predicting Treatment Response in Inflammatory Muscle Disorders Rheums looking for clues to whether their patients w/certain inflammatory myopathies will improve on immunosuppressive drugs may find them in a new study in Arthritis Care & Research. https://t.co/kXFIEMTbkb https://t.co/UbO7nSsdAY

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Dr. John Cush RheumNow ( View Tweet)
Significant mortality risk with scleroderma renal crisis. #RWCS2022 @RWCSmtg https://t.co/vIm0xDEjB3
Dr. John Cush RheumNow ( View Tweet)
Scleroderma ANA associations thru the ages. Dr. Virginia Steen @RWCSmtg #RWCS2022 https://t.co/U64gpnCgS8
Dr. John Cush RheumNow ( View Tweet)
Would combination biologics work? Maybe according to this collection of antecdotal use. #RWCS2022 @RWCSmtg https://t.co/VJdINyqLQt
Dr. John Cush RheumNow ( View Tweet)
NOR-DRUM study shows that TDM, therapeutic drug monitoring, is beneficial. Study of RA, PSA, AS, Crohn's, UC Rheums don't do this, should they? #RWCS2022 @RWCSmtg https://t.co/Dc6mgr5jrL
Dr. John Cush RheumNow ( View Tweet)
IMPACT2 shows what we see in most PSA trials- little x-ray progression. #RWCS2022 @RWCSmtg https://t.co/uYXHB0s8g0
Dr. John Cush RheumNow ( View Tweet)
Dr Artie Kavanaugh presents comparison of targeted therapies in different inflammatory disorders. #RWCS2022 @RWCSmtg https://t.co/cX00RUOgAq
Dr. John Cush RheumNow ( View Tweet)
Fecal transplant (FMT) failed to help #PsA, small trial, unexpected result. #RWCS2022 @RWCSmtg https://t.co/zKq6FONuwk
Dr. John Cush RheumNow ( View Tweet)
Proposed new pathways involving the inhibition or deletion of kindlin-2, Stat3 and Runx2 in articular chondrocytes that promotes cartilage degradation and osteoarthritis -- potential new therapeutic target for OA https://t.co/EFgGctoYJY

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Dr. John Cush RheumNow ( View Tweet)

Retrospective study of 98 patients with X-linked agammaglobulinemia (XLA) shows arthritis seen in 46% - more oligo- than polyarthritis, affecting . Knee, hip, and ankle. IVIG response rates around 70%; many w/ arthritis had missense mutation https://t.co/lreW5hkyr9

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Dr. John Cush RheumNow ( View Tweet)

Voriconazole-induced synovitis, enthesitis and periostitis described in woman treated for invasive aspergillosis. She had polyarthralgias, synovitis (MRI and US), and periostitis on xray. Voriconazole prev. caused periostitis; now drug induced arthritis? https://t.co/10MnYvD3sA

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Dr. John Cush RheumNow ( View Tweet)

New 2021 JIA guidelines w 55 recommendations, 36 conditional and 19 strong. #RWCS2022 @RWCSmtg Dr Susan Shenoi https://t.co/CMETQeOdch
Dr. John Cush RheumNow ( View Tweet)
ACR RISE registry study looked at Rx of 3276 Sarcoidosis pts from 184 rheum practices finds 59.3% rx w/ steroids (24% prolonged steroids). and 12.1 Rx w/ biologics or tsDMARDs, mostly TNFi (inflx). But wide practice-level variations in Rx https://t.co/95CEDai2uN

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MMWR study of shows 2 dose mRNA COVID vax during pregnancy was 61% effective preventing infant COVID. Among 176 infants hosp w/ COVID-19, 84% were born to mothers who were not vaccinated during pregnancy.https://t.co/mWgHHcL05u

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Saphnelo (anifrolumab) has been approved in the European Union as an add-on therapy for the treatment of adult with moderate to severe, active, autoantibody-positive systemic lupus erythematosus (SLE), despite receiving standard therapy.https://t.co/fdZAFFDrYW

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Dr. John Cush RheumNow ( View Tweet)

Study of 25/306 SLE patients (8.2%) who developed 29 episodes of Pulmonary Hemorrhage (PH). 1st manifestation . PH assoc w/ Renal dz, high SLE activity during PH; PH mortality w/ Renal failure & mech ventilation. https://t.co/ydJkgf5BFB

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Dr. John Cush RheumNow ( View Tweet)

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