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Why Are Physicians Silent About Outrageous Drug Prices?

d MedPage Today

This article was written by Dr. Milton Packer, who wonders why physicians are struggling to get their priorities straight.

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The Overpricing of Drugs (1.14.2022)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com. This week we discuss amputations, a $57 billion RA market, an FDA approved drug for Cat arthritis and drug that works in Sjogren's.

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Hold Myophenolate or Not with COVID-19 Vaccination?

d Jack Cush, MD

While the American College of Rheumatology recommends holding mycophenolate (MMF) in rheumatic and musculoskeletal diseases patients (RMD) receiving COVID-19 vaccines, there is limited data on such an approach. A recent cohort study of RMD patients showed that holding MMF yielded higher antibody responses than continuing MMF.

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COVAX Registry: Safety of COVID-19 Vaccines in Rheum Patients

d Jack Cush, MD

The EULAR Coronavirus Vaccine (COVAX) physician-reported registry has shown that the use of COVID-19 vaccines in people with inflammatory/autoimmune rheumatic and musculoskeletal disease (I-RMD) is effective, safe, and well tolerated.

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KEEPSaKe-1 Trial in Psoriatic Arthritis - IL-23 Inhibition is Effective

d Jack Cush, MD

The results of the KEEPSaKE-1 study in psoriatic arthritis (PsA) has been published and shows that risankizumab (RIZ), an IL-23 inhibitor, showed significant clinical improvements when given to active PsA patients who failed or were intolerant to ≥1 csDMARD.

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What Can JIA Patients Expect 18 Years In?

d MedPage Today

Follow-up in a Scandinavian cohort of juvenile idiopathic arthritis (JIA) patients that began in 1997-2000 revealed a number of surprises, a new study indicated.

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ICYMI: Duloxetine added to usual analgesics failed to improve pain in 132 hip or knee OA pts by WOMAC pain scores: 1) Dulox + usual care vs 2) Usual care showed no diff in pain at 3 mos or 12 mos. https://t.co/2luWWDYP81 https://t.co/KAmqlnofVv

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Dr. John Cush RheumNow ( View Tweet)
New podcast! Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow. This week we discuss amputations, a $57 billion RA market, an FDA approved drug for Cat arthritis and drug that works in Sjogrens. https://t.co/Pg4snhCZyo https://t.co/ruzRs0ypcn https://t.co/zwI8baPEcn

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Dr. John Cush RheumNow ( View Tweet)
Why Are Physicians Silent About Outrageous Drug Prices? https://t.co/hLrUFCiKwm https://t.co/ZgRoW9Duo6

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Dr. John Cush RheumNow ( View Tweet)
Hold Myophenolate or Not with COVID-19 Vaccination? https://t.co/9Bp8huqJ6M https://t.co/AD11BmoZE8

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Dr. John Cush RheumNow ( View Tweet)
COVAX Registry: Safety of COVID-19 Vaccines in Rheum Patients  https://t.co/MrywKZKcIV https://t.co/QgajVPdesg

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Dr. John Cush RheumNow ( View Tweet)
Study 126 rheumatic disease (RMD) patients showed that post-vaccination flares of RMD are rare. Despite being on DMARDs, biologics, immunosuppressives, the rate of RMD reactivation was 0.007 person/mo. 5 mild articular flares in 3 women https://t.co/OWXWTedw3Q

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Dr. John Cush RheumNow ( View Tweet)

Can PPI accelerate knee OA? UK cohort compared need for TKR in adults over 50yrs on PPI or H2 blockers. Those on omeprazole and pantoprazole had 21%-3& more TKR than H2B (but not elevated with lansoprazole, rabeprazole (HR=0.97) https://t.co/5TqFV3TpjG

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Dr. John Cush RheumNow ( View Tweet)

FDA has approved an NGF inhibitor for arthritis in cats...yes CATS! Presumeably for OA, Solensia (frunevetmab) is a cat-specific MAb that binds nerve growth factor (NGF). In humans several NGF MAbs have failed (tanezumab in 2021) https://t.co/WcvXP8Bv21

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Dr. John Cush RheumNow ( View Tweet)

KEEPSaKe-1 Trial in PsA - IL-23 Inhibition is Effective The KEEPSaKE-1 study in PsA has been published and shows that RIZ showed significant clinical improvements when given to active PsA patients who failed or were intolerant to ≥1 csDMARD. https://t.co/thYavd4dAR https://t.co/HnVtsrUgVB

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Dr. John Cush RheumNow ( View Tweet)
JAMA cohort study of 5.9 million VA pts and with & without gout ( 556 521)-gout pts had higher rates of lower extremity amputation (HR 1.59), than those without gout. This was assoc w/ poor uric acid control (>7), but not urate lowering therapy. https://t.co/KiM3IBCCp4

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Dr. John Cush RheumNow ( View Tweet)

Global Burden of Disease Study shows that globally, from 1990 to 2019, the age-standardized incidence rate (ASIR) of hip osteoarthritis increased from 17.02 per 100,000 persons to 18.70 per 100,000 persons https://t.co/OJOnkAw1Dy

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Dr. John Cush RheumNow ( View Tweet)

JAMA study shows that, compared with usual care, colchicine did not significantly reduce mechanical ventilation or 28-day mortality in patients hospitalized with COVID-19 pneumonia (HR 0.83; 95% CI, 0.67-1.02; P = .08). https://t.co/6dRd6gnkjc

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Dr. John Cush RheumNow ( View Tweet)

NEJM: A 14-year-old boy was admitted to this hospital because of fatigue, fever, joint pain, abdominal cramping, and diarrhea. Start w/ Sore, throat, then polyarthritis (knees, Shoul), fever 39.4C. Very high WBC, CRP & lipase. Whats the Dx?

Dr. John Cush RheumNow ( View Tweet)

Biomarker study of 21 systemic juvenile idiopathic arthritis (sJIA) shows you can differentiate between active & inactive disease. From 69 biomarkers, these were predictive: IL-6, MMP1, S100A12 (p < 0.0001), HMGB1; but IL-18 elevated in both groups! https://t.co/m2yXTITzwY

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Dr. John Cush RheumNow ( View Tweet)

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