All News
Indications Awaiting (12.17.21)
There's good news and bad news in rheumatology fellowship matching for 2022. There's also new FDA approvals and indications, but a new serious safety warning has arisen from the CDC about the J&J COVID-19 vaccine.
Dr. Jack Cush reviews the latest news, journal reports, regulatory approvals, plus 3 new cases from rheumatologists.
NSAIDS Prevent Heart Attacks in PsA
https://t.co/QkJJOyK7o4 https://t.co/VDBCDHPDZ5
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CNS Dysfunction & Blood Brain Barrier Leakage in SLE
Dr. Jack Cush reviews the ACR21 Plenary Session presentation showing half of lupus patients have cognitive deficits and that these can be correlated with brain abnormalities including BBB permeability.
https://t.co/HoEhqkhVlc
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ICYMI: Tofacitinib 1st JAK Inhibitor Approved for Ankylosing Spondylitis
The FDA approved tofacitinib (Xeljanz, Xeljanz XR) for treating active ankylosing spondylitis in adults, Pfizer announced.
https://t.co/nkMJUfHF6r https://t.co/cIUMVtDIKd
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Dr. John Cush RheumNow ( View Tweet)
ICYMI: RESTORE trial: yet another failure for PRP injections for knee #OA. Study of 288 Knee oA over 50 years - knee pain scores of −2.1 vs −1.8 on an 11-point scale (range, 0-10) and no difference between PRP and PBO at 12 moshttps://bit.ly/3p6GMf5
Dr. John Cush RheumNow ( View Tweet)
ICYMI: NEJM Clinical Images - Tongue Necrosis in Giant Cell Arteritis. 74-yoF w/ 3-day hx of HA and tongue swelling/pain, & blindness in the right eye. Tongue was ulcerated, R temporal artery thickened. ESR 42 CRP 169 mg/L. Read rest of story... https://t.co/ubqxhkvmY7 https://t.co/NAAD62XjpY
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ICYMI: Rinvoq FDA Approved for Active Psoriatic Arthritis
https://t.co/1ysUj0GUqw https://t.co/fmDA9UyFY3
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Dr. John Cush RheumNow ( View Tweet)
🆕 Myositis Specific Antibodies (MSAs): Clinical Features and Treatment for #Myositis/IIM 💪🏽
💪🏻Proximal Muscle Weakness
🫁 Interstitial Lung Disease
🤚🏽 Cutaneous [Dermatomyositis]
#RheumTwitter #DermTwitter #PulmTwitter #MedEd https://t.co/TCwpLI1yNr
Mithu Maheswaranathan, MD MithuRheum ( View Tweet)
Risk and prognosis of SARS-CoV-2 infection and vaccination against SARS-CoV-2 in rheumatic and musculoskeletal diseases: a systematic literature review to inform EULAR recommendations https://t.co/ljqEjZNwx5 https://t.co/8fVIskV3gd
Pedro Machado pedrommcmachado ( View Tweet)
ICYMI: Increased risk death in 310 scleroderma pts: 63 diffuse SSc, 279 limited dz & 33 sine scleroderma (SMR = 1.88). Reduced survival at 10 yrs (78%) & 15 yrs(61%). 69 deaths, 46% in diffuse PSS - due to ILD, PHA, and GI involvement https://t.co/OZg8QamhEB
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Dr. John Cush RheumNow ( View Tweet)
There's good news and bad news in rheumatology fellowship matching for 2022. There's also new FDA approvals and indications, but a new serious safety warning has arisen from the CDC about the J&J COVID-19 vaccine. All that a more on this week’s podcast.
https://t.co/gklOK2S1QC https://t.co/QrYg1QZKhJ
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Certain Cancers Increased with Autoimmune Diseases
Rheumatologists are well aware that inflammation and immune dysregulation are prime contributors to cancer risk, but do oncologists carry the same impressions?
https://t.co/00SZ9nSX0I https://t.co/yXGehFTjF6
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Dr. John Cush RheumNow ( View Tweet)
CDC Panel Recommends mRNA COVID Vaccines Over J&J Vaccine
The CDC has recommended the two authorized mRNA COVID-19 vaccines over J&J adenovirus COVID-19 vaccine, primarily due to the rare reports of thrombosis with thrombocytopenia syndrome (TTS).
https://t.co/qjZlzE7top https://t.co/UKsLbtRNv2
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Dr. John Cush RheumNow ( View Tweet)
Telemedicine? Surveys (patients=1340, MD=111) & interviews (pts= 31, MD= 29) April 2021 and July 2021. Results suggest pts and MDs prefer F2F over Telemedicine almost all categories. Some negatives may be due to the pandemic https://t.co/TdOORCfx6l
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Dr. John Cush RheumNow ( View Tweet)
Tofacitinib 1st JAK Inhibitor Approved for Ankylosing Spondylitis
The FDA approved tofacitinib (Xeljanz, Xeljanz XR) for treating active ankylosing spondylitis in adults, Pfizer announced.
https://t.co/NczbrBXBl7 https://t.co/l93OM86qaX
Links:
Dr. John Cush RheumNow ( View Tweet)
UCB released results of BE MOBILE 2 Phase 3 study of bimekizumab, a dual IL-17A and F inhibitor, in active ankylosing spondylitis. Showing at wk 16 superiority of BIM over PBO in ASAS40, BASDAI, ASDAS, ASAS partial remission https://t.co/Jt8mpxUCv0 https://t.co/T5QpJu8n6r
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Dr. John Cush RheumNow ( View Tweet)
CV mortality with infection & inflammation studied using CDC database; From 1999 to 2018 CV mortality decreased in general population (40.9 to 30.6%) but increased w/ HCV (7.0 -10.2%) & HIV (1.9 to 6.7%); decreased in plateaud in IBD, PSO, RA, and SLE https://t.co/Oiv92xRs6W
Dr. John Cush RheumNow ( View Tweet)
RESTORE trial: yet another failure for PRP injections for knee #OA. Study of 288 Knee oA over 50 years - knee pain scores of −2.1 vs −1.8 on an 11-point scale (range, 0-10) and no difference between PRP and PBO at 12 moshttps://bit.ly/3dZ5ebW
Dr. John Cush RheumNow ( View Tweet)
SOBI has received a positive opinion by the EMA's CHMP on Kineret (anakinra) for the treatment of COVID-19 in adult patients with pneumonia requiring supplemental oxygen or at risk for progressing to severe respiratory failure. Final approval pending https://t.co/1bJYae38hw
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Dr. John Cush RheumNow ( View Tweet)