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Risks associated with mortality in VEXAS

d Md Yuzaiful Md Yusof, MRCP(UK), PhD

Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome (VEXAS) took the centre stage when it was first introduced at ACR20 last year. It got everyone’s thinking that they might have encountered one or two patients in their rheumatology lifetime who might have this condition.

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FDA Puts Boxed Warnings on JAK Inhibitors

d Jack Cush, MD

Based on the safety review of tofacitinib in Pfizer's Oral Surveillance (1133) study, the FDA has added serious boxed warnings to all three marketed JAK inhibitors (for inflammatory diseases) and formalized the recommendation that patients should be started on a TNF inhibitor (TNFi) before trying a JAK inhibitor. These recommendations apply to tofacitinib, baricitinib and upadacitinib.

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TNF inhibitors and radiographic progression in axSpA

d Aurelie Najm, MD, PhD

A remaining challenge for clinicians is the ability to delay, if not completely stop, structural progression in patients with axSpA, whether they are diagnosed with radiographic (r-axSpa) or non-radiographic (nr-axSpA) disease.

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CDC and the ICD-10 Coordination and Maintenance Committee has assigned a diagnostic code for non-radiographic axial spondyloarthritis (nr-axSpA) == M45.A

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TNF Inhibitor Panel Discussion: ACR21 Annual Meeting https://t.co/Kpj80YoDmN https://t.co/AChUVw17oc

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Download Available! AOSD Disease Patterns Over Time https://t.co/qZBtCQ2QAg https://t.co/fMmN1PAzFG

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TNF inhibitors and radiographic progression in axSpA A remaining challenge for clinicians is the ability to delay, if not completely stop, structural progression in patients with (ax-Spa, whether they are diagnosed with -axSpa or nr-axSpA disease. https://t.co/Gn9vFlq0Bd https://t.co/CXdlU0HQG8

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ICYMI:Methotrexate and hepatic fibrosis: we must be doing something right Despite methotrexate’s use in rheumatology, and the consequent frequency of patient counselling about it, relatively little is known about what precautions are absolutely required. https://t.co/AMvnQnMUUl https://t.co/aRzsy4ZA8z

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ICYMI: New Insights into Uveitis in Spondyloarthritis Uveitis is the most frequent extra-musculoskeletal manifestation (EAM) in Axial Spondyloarthritis (axSpA). Read more on RheumNow. https://t.co/JF7TtE8SVJ https://t.co/Sw2b1WX5ko

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ICYMI: Diagnosing (Bad) VEXAS: The Experts Speak Dr. Cush discusses Dr. Marcela Ferrada and Dr. David Beck to discuss VEXAS syndrome and abstract 1426, which was presented at the ACR21 annual meeting. https://t.co/oafDX0rJIl https://t.co/UoNpjABLNd

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Guselkemab vs. Ustekinumab in PsA https://t.co/JCs5VpkyUK https://t.co/OzRtdWtqXp

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ICYMI: DORIS - Defining Remission in Lupus Proponents of treat to target in systemic lupus erythematosus (SLE) have all agreed that "remission" should be the goal, but defining remission may be tricky in SLE. Read on... https://t.co/hVfzAtRzgY https://t.co/hSPz1eASzF

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ICYMI: Giant Cell Arteritis Novel Treatment Options https://t.co/ywqGZNmHOa https://t.co/2hLESL1RjO

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ICYMI: IL-35 (blood and urine) is elevated in #SLE pts with nephritis. Small study of 42 SLE pts serum IL-35 had 90% sensitivity & 65% specificity while urine IL-35 had 86.4% sensitivity and 75% specificity to establish the diagnosis of LN https://t.co/SgmGDSU8dZ

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Telemedicine Upside Interview with Dr. Alvin Wells Dr. Jack Cush interviews telemedicine guru, Dr. Alvin Wells, on the current state of telemedicine and what the future holds for telehealth in rheumatology. https://t.co/iOpKqjIVuP https://t.co/emseMx4iZ0

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Spondyloarthritis Panel Discussion: ACR21 Meeting Drs. Antoni Chan, Robert Chao, Rachel Tate, Sheila Reyes and Akhil Sood discuss abstracts #0562, #1919, #0907, #0364 and #0919 @synovialjoints @doctorRBC @uptoTate @RHEUMarampa @AkhilSoodMD https://t.co/g0ARcP26wt https://t.co/8Lpwpf6AI1

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Watch Now: Can We Stop Medication in Systemic JIA? https://t.co/yRIb70YVME https://t.co/EJ2PmC6xKY

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Third Time's the Charm - COVID Vaccination While on Rituximab https://t.co/3j0KeQtzw1 https://t.co/YvgpaDX7tv

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Rheumatoid arthritis (RA) has been linked to a higher risk of dementia and cognitive dysfunction, but interestingly this association has diminished in the last few decades with aggressive DMARD and targeted therapies. https://t.co/T1feTkSKQv https://t.co/XElvgsGC0E

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Best of PsA Day 4 - MACE in PsA https://t.co/NTM1GR7d5W https://t.co/ZxPJ8jDXhD

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