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Another study linking long term GC and CV risk in RA!
Medicare data >65yo 130000+ pts
1-year incidence CV ⬆️ as follows:
📍Dose ≤5mg 1.4%
📍Dose 5-10mg 1.7%
📍Dose >10mg 1.9%
Not replicated in younger pts (Optum data)
#ACR21 #Abst1915 @RheumNow https://t.co/DLXdfvfiBW
Aurelie Najm AurelieRheumo ( View Tweet)
#ACR21 2022 ACR/EULAR EGPA Criteria
▶️Classification, NOT diagnostic!
⭐️Clinical: obstructive airway, polyps, MM
⭐️Labs: eosinophilia & extravasc eos-inflamm bx, negative points for Hematuria, cANCA or PR3
- Least sensitive: 85%, but 99% specific
@RheumNow https://t.co/6YWmabNzuH https://t.co/kLVqXzNTEf
Links:
Eric Dein ericdeinmd ( View Tweet)
If #dermatomyositis, it is TIFgamma1 that has the high risk of #cancer. If you can order this #AB and it is negative in adults do we need to do cancer screen at baseline? and repeatedly? Need more data. Great observation though. #myositis hub #ACR21 abst#688 @RheumNow https://t.co/zeQl0DACbJ
Janet Pope Janetbirdope ( View Tweet)
#ACR21 #Abstr1908 Potential prognostic biomarker for lymphoma in #sjogren. ISG15 (IFN-I) expression was consistently ⬆️in pts with lymphoma vs none, both in blood and salivary gland biopsy. Work needed re: relation to other markers, ethnicity @RheumNow https://t.co/8VYYEXpXSw https://t.co/ZIkpx5kUfu
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Abst 1916
England & colleagues determined if anti-MAA Ab = predictor of incident RA-ILD
- Anti-MAA Ab significantly associated w/ incident RA-ILD
- Strongly associated w/ higher concentrations anti-MAA
- Antibody associations = antigen/isotype dependent
#ACR21 @RheumNow https://t.co/z1RspmxBvc https://t.co/hvUm4O6RmX
Akhil Sood MD AkhilSoodMD ( View Tweet)
DAS-28 independently associated survival in RA-ILD. As I keep saying, treating the rheumatoid disease properly is the current best strategy for treating RA-ILD. Abstr#1918 #ACR21 @RheumNow #ACRBest https://t.co/FpUK6upyOi
Richard Conway RichardPAConway ( View Tweet)
@Will_I_Am_Osler @zach_wallace_md @RheumNow Very nice, amazingly similar!
- also 3/4 with IgG4 >5xULN
- similar list of other diseases
wonderful to have correlation over multiple continents, the beauty of an international meeting like #ACR21! https://t.co/vabBKNbd7u
David Liew drdavidliew ( View Tweet)
Machine learning algorithm demonstrated high level of accuracy (88%) and precision (0.95) in diagnosing potential cases of axSpA
⭐️Is there a role for ML to facilitate faster rheum eval for suspicious axSpA cases?
Abs#1922
#ACR21
@RheumNow
https://t.co/tAPfROPICU https://t.co/HJD37B9jZw
Links:
Robert B Chao, MD doctorRBC ( View Tweet)
Is there a relationship between the weather and RA disease activity?⛈️
#ACR21 Abs#1912
🌡️Temperature & humidity significantly affect pain, TJC & SJC
🌦️PGA was mostly influenced by humidity
Should we take the weather into account when assessing patients?
@RheumNow https://t.co/e3PewZWkLR
Mrinalini Dey DrMiniDey ( View Tweet)
RA ILD survival. The ‘smoking’ gun! RA ILD in VA pts mostly menand smokers - data showed disease activity of #RheumatoidArthritis & ⬆️HAQ both reduced survival independently #ACRBest #ACR21 abst#1918 @RheumNow https://t.co/8GD7rHV07t
Janet Pope Janetbirdope ( View Tweet)
Preventive Window of Opportunity in RA? Dr. Aurelie Najm ( @AurelieRheumo) discusses abstract #0455 presented at the #ACR21 annual meeting.
https://t.co/bCN1k5hhUc https://t.co/gpEHk0XIRc
Links:
Dr. John Cush RheumNow ( View Tweet)
PsO vs PsA patient and disease characteristics COPPAR registry:
PsO pts 🔼mean BSA
Both 🔼 % of biologic therapy
sPGA and PASI 🔼PsO
🔽QOL and physical health in PsA
🔼daily work impairment PsA
Abst # 1779 #ACR21 @RheumNow
swethaann23 swethaann23 ( View Tweet)
🚫Infection risk after COVID vaccination: US database
536 954 Controls and 47 303 pts w/ RMDs
〽️BNT162b2 19 vs. 36/1000
〽️ mRNA-1273 16 vs. 33/1000 〽️Janssen 26 vs. 47/1000
Infections ⬆️ RA, SpA, SLE, SSc, Polymyositis
#ACR21 #AbstL16 @RheumNow
https://t.co/xzOaFIu06e
@RheumNow https://t.co/tmr4USETJ3
Links:
Aurelie Najm AurelieRheumo ( View Tweet)
#ACR21 2022 ACR/EULAR Large Vessel Vasculitis Criteria:
🌎One reason for updating 31 year old criteria -> now an international effort that better reflects heterogeneous global disease
@RheumNow https://t.co/6YWmabNzuH https://t.co/YXm85uQZCK
Links:
Eric Dein ericdeinmd ( View Tweet)
#ACR21 #Abstr1909 📢We need to stress the importance of hydroxychloroquine adherence to our patients. Adherence (>90% of the time) reduced premature CVD mortality by 52% in #rheumatoidarthritis and #lupus. The study didn’t adjust for smoking @RheumNow https://t.co/D9pGqwWhje https://t.co/R6r3cSexUB
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Looking forward to the #ACR21 roundup by Drs. Cush and Kavanaugh at 7pm EST tonight. Always entertaining and informative. A highlight of ACR for me. We met in person the last time in Atlanta #ACR19. It’s virtual & the link is at @RheumNow Hope to meet in person again #ACR22 🤞 https://t.co/pgAcBExL7G
Dr. Antoni Chan synovialjoints ( View Tweet)
Can we predict who will develop #RA-ILD?
Perhaps anti-MAA is the answer!
#ACR21 Abs#1916
👉🏼⬆️anti-MAA antibody assoc with incident ILD risk
👉🏼Associations are antigen &
isotype dependent
👉🏼Antibody measurement may be useful to risk stratify for RA-ILD
@RheumNow https://t.co/nC0OkuWtGU
Mrinalini Dey DrMiniDey ( View Tweet)
ORAL Surveillance: MACE and malignancy are getting all the attention...
but did you know that non-zoster infections are also more likely with tofacitinib vs TNFis?
#ACR21 ABST1684 @RheumNow https://t.co/GiBkvPYs4j
David Liew drdavidliew ( View Tweet)
ACR/EULAR Classification Criteria for Large Vessel Vasculitis (TAK/GCA), updated from prior to include imaging
Must emphasize typical disclaimers; these are for classification, not specifically for diagnosis
Great effort and useful result, esp for trials
#ACR21 @petercgrayson https://t.co/IYFyh5oYBT
Mike Putman EBRheum ( View Tweet)
⭐️Ustekinumab+MTX vs. UST+PBO in PsA?
➡️Additional MTX has no positive impact on UST efficacy for arthritis, enthesitis, dactylitis, skin, QoL, & function.
*️⃣Thus, no evident to add or maintain ongoing MTX when starting UST
Late-Breaking Poster#12. #ACR21 @RheumNow #ACRBest https://t.co/k96PPUtwct
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)