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Physical Therapy is More Cost-Effective than Intraarticular Steroids in Knee OA

d Jack Cush, MD

A randomized trial compared the incremental cost-effectiveness of physical therapy and intra-articular glucocorticoid (IA GC) injection as initial treatment for knee osteoarthritis showed that physical therapy gained more quality-adjusted life-years compared with those receiving glucocortico

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Allopurinol Safety in CKD Patients

d Jack Cush, MD

A study in the Annals of Internal Medicine reports chronic kidney disease (CKD) patients can be safely treated with allopurinol without an increased risk of mortality.

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How Preventable Is Rheumatoid Arthritis?

d MedPage Today

Women who made at least four healthy lifestyle choices saw their risk of developing rheumatoid arthritis reduced significantly, an analysis of Nurses' Health Study (NHS) data found.

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FDA Approves Skyrizi for Active Psoriatic Arthritis

d Jack Cush, MD

On Friday, the U.S. Food and Drug Administration (FDA) approved risankizumab-rzaa (Skyrizi) for the treatment of adults with active psoriatic arthritis (PsA), with similar dosing in plaque psoriasis - a single 150mg subcutaneous injection four times a year after two starter doses (at weeks 0

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DECT scanning for MSU deposits in the vasculature of 6 cadavers w/ Gout (2 tophaceous) did not demonstrate MSU crystal deposition in vessels, but did show MSU in the joint (positive control) and MSU in joint aspirates by polarizing microscopy https://t.co/y5SoRcmqoR

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NEJM clinical case - A 42 yoM w/ red, painful eyes, facial-nerve palsy OS, a large oral ulcer, and petechiae. +ANCA, +PR3. Skin biopsy revealed leukocytoclastic vasculitis with perivascular eosinophils. Dx eosinophilic granulomatosis with polyangiitis https://t.co/bPEjJr63zF

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Cognitive Function and Rheumatoid Arthritis: Dr. Akhil Sood Interviews Dr. Elena Myasoedova https://t.co/SkB3b4wfIj https://t.co/sXNXlbDddG

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MMWR reports >40,000 pregnant women who received COVID-19 vaccination during pregnancy- VAX not associated with preterm birth or small-for-gestational-age at birth overall compared with unvaccinated pregnant women. https://t.co/FIdJ29cOl7

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We have an exciting agenda for #RNL2022, with a pod on the Spondyloarthritis Spectrum and more , as well as speakers from around the world, including Dr. Jose Scher, who will lead a discussion on The Microbiome in Spondyloarthritis . Register Today! https://t.co/rZIrSzz6EN https://t.co/iGEN0hAKcg

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We are excited to announce that Dr. Janet Pope will be joining us at RheumNow Live, leading a presentation on Drug Cycling vs Switching in RA. Join the discussion on March 19-20, on site or virtually! https://t.co/RfWz53vem3 https://t.co/9n1UzFrkVb

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ICYMI: The CDC's Advisory Committee on Immunization Practices recently recommended & approved 2 doses of the recombinant zoster vaccine for prevention of herpes zoster and complications in immunodeficient/immunosuppressed adults aged ≥19 years. https://t.co/VlA5BIyrZG https://t.co/VjBHtCNq37

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ICYMI: UCB announced positive top-line results from Phase 3 BE COMPLETE study, bimekizumab, in active psoriatic arthritis, who failed TNFi. Bimekizumab pts showed a 50% ACR50 at week 16, as well as signif improvements in PASI90, MDA, PGA https://t.co/HhVdIhqHoL

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Dr. John Cush RheumNow ( View Tweet)

FREED study (asympt hyperuricemic without gout) showed febuxostat x 24 mos dint alter carotid atherosclerosis, but at 3 years, (Substudy of 1004 pts), showed FEB signif lowered risk of CVA, CV, renal renal events and death (vs PBO) https://t.co/BS4wiIaYZv

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New podcast available! Dr. Jack Cush reviews the news and journal articles from this past week on https://t.co/V10S4oVFsv. These reports are about better outcomes in Lupus; fewer Gout flares with T2T and the power of belief. https://t.co/8sxDTiU9QD https://t.co/bc8A1FWkVS

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ICYMI: Network metanalysis (28 RCTs, 12 504 pts) of Biologics & small molecules therapy in active ulcerative colitis. Upadacitinib 45 mg qd ranked 1st (RR 0.73) vs PBO, infliximab 5 mg/kg & 10 mg/kg ranked 2nd & 3rd. UPA > TNFi at remission. https://t.co/ne6yfBEJJz

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ICYMI: FDA has approved 2 JAK inhibitors for use in severe atopic dermatitis (eczema) - Abbvies upadacitinib (Rinvoq) and Pfizers abrocitinib (Cibinqo). https://t.co/6wdyN6NvVa https://t.co/RfliRSH5Kf

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ICYMI: Annals of Internal Medicine describes a propensity matched comparison study of risedronate and alendronate, showing that, compared to alendronate, risedronate drug holidays were associated with a small increase in risk for hip fractures. https://t.co/6qnMUzqV3E https://t.co/iIrahEuB09

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: JAMA reports that between Dec 2020 and July 2021, COVID-19 vaccination saved nearly 241,000 lives, prevented 1, 133, 617 hospitalizations and prevented more than 14 million COVID-19 cases (all in 1st 6 mos of the COVID vaccines) https://t.co/q9TvLjtY9p

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ICYMI: Infliximab treatment of RMD/IMIDs by targeting drug levels (therapeutic drug monitoring) was superior to usual care in study with more sustained Dz control without worsening in 458 IMID pts Rx for 52 weeks (TDM 74% vs 70% standard Rx) https://t.co/KsnQxYXHkI

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Dr. John Cush RheumNow ( View Tweet)

UCB announced positive top-line results from Phase 3 BE COMPLETE study, bimekizumab, in active psoriatic arthritis, who failed TNFi. Bimekizumab pts showed a 50% ACR50 at week 16, as well as signif improvements in PASI90, MDA, PGA https://t.co/pnhQKeUxKt

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Dr. John Cush RheumNow ( View Tweet)

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