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RETRO - Taper or Not: You Decide
A prospective, phase 3 trial of rheumatoid arthritis (RA) patients in sustained remission has shown more than half will flare if disease-modifying antirheumatic drugs (DMARD) therapy is tapered or discontinued and that remission is best maintained by continued DMARD therapy.
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WHO's Strategic Advisory Group on immunisation has advised an addition COVID vaccination in those >60 years and the immunosuppressed (due to a higher risk of breakthrough infections) https://t.co/NcGr8EMDaO
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Dr. John Cush RheumNow ( View Tweet)
The CDC estimates of the national prevalence of arthritis and arthritis-attributable activity limitations (AAAL) show a continued increase in absolute number: 58.5 million US adults have arthritis, 25.7 million of whom have AAAL.
Read more on #RheumNow
https://t.co/9RNIduVCZh https://t.co/fzxWMbcEfU
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Dr. John Cush RheumNow ( View Tweet)
Most common reasons for starting canakinumab? Survey of 58 MDs (caring for 147 febrile pts) 1) perceived efficacy(81%), 2) lack of prior response (41%), 3) good safety (40%). Efficacy w/ HIDS/MKD (91%), no response w/ FMF (52%) https://t.co/JjxaUyBnyB
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Dr. John Cush RheumNow ( View Tweet)
Clinical Associations with Myositis Antibodies
Read the full article on #RheumNow
https://t.co/tzPU1scc8x https://t.co/xxF1gIulwY
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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Several studies have suggested that biologic Rx of Psoriasis may lower risk of later PsA. New study of nearly 2 million PSO (15k given biologic, 20K given oral Rx). The risk developing PsA higher w/ biologic (aHR 4.48) vs oral or phototherapy https://t.co/Na5EfWelkY https://t.co/0sL18UWjhO
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Dr. John Cush RheumNow ( View Tweet)
We are reviewing cases from Ask Cush Anything and almost a dozen news items and reports on this week’s podcast. Download today.
https://t.co/Xb81eWEZ1q https://t.co/K6zPKtwAD7
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Dr. John Cush RheumNow ( View Tweet)
ICYMI: An erosive hand osteoarthritis (EOA) study from the Osteoarthritis Initiative shows that EOA is more common in older women and is strongly linked to further progressive, articular structural damage.
https://t.co/XOVKNj423l
#RheumNow https://t.co/CYxW6mJpCH
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Dr. John Cush RheumNow ( View Tweet)
ICYMI:
Upadacitinib RA program (5306 pts) the risk of H. zoster by Rx and dose (HZ/100PYs)
MTX = 0.8/100PY
ADA+MTX= 1.1/100PY
UPA 15 mg= 3.0/100PY
UPA 30 mg = 5.3/100PY
Hence there is a 4-5X risk of HZ w/ JAKinhibitors
https://t.co/wo9ih5PJ77
#RheumNow https://t.co/h1GoGzADdv
Links:
Dr. John Cush RheumNow ( View Tweet)
ICYMI:
“Hiker’s feet” newly proposed cutaneous foot manifestations of dermatomyositis. Most pts had the antisynthetase syndrome (with anti-Jo-1) and almost all had mechanic’s hands. Such findings should prompt a search for ILD https://t.co/98EAQUHJbz https://t.co/Cw6rSIUyW2
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Dr. John Cush RheumNow ( View Tweet)
ICYMI:
The AAOS has published their Clinical Practice Guideline for Management of Osteoarthritis of the Knee (Non-Arthroplasty); updating 19 of 29 evidence-based recommendations and focuses on nonsurgical treatmentss to provide pain and patient function.
https://t.co/faLi0WQt8F https://t.co/PI7jYN1VB9
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Dr. John Cush RheumNow ( View Tweet)
ICYMI:
Secukinumab (IL-17 inhibitors) can be safely used in HIV spondyloarthritis patients. https://t.co/hpCRJkR9w7 https://t.co/qwbrvGkriX
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Dr. John Cush RheumNow ( View Tweet)
ICYMI:
ASBMR meeting presented results of the ASTEROID trial in osteogenesis imperfecta; Setrusumab, investigational Mab inhibitor of sclerostin, failed to improve radial trabecular BMD (primary endpt), but did improve lumbar/hip/femoral BMD https://t.co/xSDIiffjb7 https://t.co/H4Cl8rH3Bq
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Dr. John Cush RheumNow ( View Tweet)
ACR 2021 is just a few weeks away - are you ready? I'll review cases and questions submitted by viewers in Ask Cush Anything (#ACA). This, and nearly a dozen news items and reports, are discussed in this week's podcast.
https://t.co/Xb81eWEZ1q https://t.co/bJqkEyx2Mg
Links:
Dr. John Cush RheumNow ( View Tweet)
Read more about Pathways to a Psoriatic Arthritis diagnosis on #RheumNow
https://t.co/lIaddvq4q1 https://t.co/G6BOUMvyjc
Links:
Dr. John Cush RheumNow ( View Tweet)
An erosive hand osteoarthritis (EOA) study from the Osteoarthritis Initiative shows that EOA is more common in older women and is strongly linked to further progressive, articular structural damage.
https://t.co/XOVKNj423l https://t.co/gaPfj17IrB
Links:
Dr. John Cush RheumNow ( View Tweet)
Epi-4 studies of 4,376 military service persons shows the prevalence of fibromyalgia = 2.9% predeployment, but was significantly higher in those with postemployment PTSD (10.8%) (not without PTSD-0.8%) but higher if in PTSD RCTs (40%) https://t.co/95tCsMtoyw https://t.co/DpMQqPVfhP
Links:
Dr. John Cush RheumNow ( View Tweet)
Several studies have suggested that biologic Rx of Psoriasis may lower risk of later PsA. New study of nearly 2 million PSO (15k given biologic, 20K given oral Rx). The risk developing PsA higher w/ biologic (aHR 4.48) vs oral or phototherapy https://t.co/Na5EfWelkY https://t.co/6wOIm8P2gQ
Links:
Dr. John Cush RheumNow ( View Tweet)
Upadacitinib RA program (5306 pts) the risk of H. zoster by Rx and dose (HZ/100PYs)
MTX = 0.8/100PY
ADA+MTX= 1.1/100PY
UPA 15 mg= 3.0/100PY
UPA 30 mg = 5.3/100PY
Hence there is a 4-5X risk of HZ w/ JAKinhibitors
https://t.co/wo9ih5PJ77 https://t.co/Zv9sSRBSHb
Links:
Dr. John Cush RheumNow ( View Tweet)