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Wait, let me scan your joints first! Early arthritis clinics: US examination prior first clinical review in cohort of 163: ⬇️
⭐️time to diag from mean 31 days to 12
⭐️n° of clinical visits - 114 visits over a year
⭐️n° of revised diag at 1yr 5 vs 16% #POS0260
#EULAR2021 @Rheumnow https://t.co/CLkNqZUJVQ
Aurelie Najm AurelieRheumo ( View Tweet)
Subclinical US enthesitis in 174 IBD patients w/ or w/out PSO:
-High prevalence of structural damage ≥1 enthesis 83.4%
-≥1 active enthesitis 25%
in IBD + PSO:
-⬆️ ≥ 1 thickened enthesis 86% vs 64% p=0.009)
-⬆️of PD signal at knee examination.
#POS0265 @RheumNow #EULAR2021 https://t.co/8f7G5ku1kc
Aurelie Najm AurelieRheumo ( View Tweet)
Adelphi RA Disease Specific Program: Physician survey on T2T strategy implementation in RA. #POS0305
What is main objective in RA T2T?
@Rheumnow #EULAR2021
Aurelie Najm AurelieRheumo ( View Tweet)
ESPOIR cohort 598 patients w/ EVA fatigue for 10yrs: 3 fatigue trajectories high, moderate and low, consistent over time. Predictors of high fatigue trajectory: female gender, pain, psychological distress, presence of sicca symptoms. Effect of tmts? @Rheumnow #EULAR2021 #POS0308 https://t.co/iMLKFPikaR
Aurelie Najm AurelieRheumo ( View Tweet)
Depression is not only associated with high PGA but also with inflammatory markers in RA! Cross-sectional study of 258 patients: Depression (PHQ-9>10) associated with DAS28-ESR OR 1.1, DAS28 CRP OR 1.1, PGA AND CRP OR1.3 in multivariate analysis.
@Rheumnow #POS0312 #EULAR2021 https://t.co/66CaqLp61r
Aurelie Najm AurelieRheumo ( View Tweet)
Is genetic of RA remission different? Neither genetic risk score comprising RA susceptibility variants (OR 0.99 0.94-1.03) nor HLA-SE (OR 0.8 0.75-1.01) are associated with DAS28CRP<2.6 at 6 month in this MA of 8 inception cohorts (4425 patients) @RheumNow
#EULAR21 POS0348 https://t.co/rvGovxTlRo
Aurelie Najm AurelieRheumo ( View Tweet)
In a new scientific era dominated by high throughput technologies, statistical analysis is at least as important than samples quality. Different data modeling strategies applicable to ScRNASeq discussed by Dr @YvanSaeys in the #EULAR2021 Investigative Rheumatology. @Rheumnow https://t.co/eMcNfWIxM2
Aurelie Najm AurelieRheumo ( View Tweet)
EUSTAR database: in 474 patients w/ no baseline ILD, t0 DLCO value<80% predicted ILD on HRCT at 2years w/ OR 3.1 [1.49-6.40]p=0.0023 while t0 FVC value<80% didn't reach statistical significance OR 1.95 p=0.13. To be confirmed in prospective studies! @RheumNow #EULAR2021 #POS0317 https://t.co/haNlN0OfX4
Aurelie Najm AurelieRheumo ( View Tweet)
COVAX Registry: 1519 patients w/ 51% IA, 45% CsDMARDs, 36% bioDMARDs, 31% GCs; vaccinated with Pfizer, AZ or Moderna. Overall, very reassuring safety profile. 5% flares. Efficacy to trigger AB response needs to be further assessed.
@pedrommcmachado #LB0004 @Rheumnow #EULAR2021 https://t.co/1dSfOJALzf
Aurelie Najm AurelieRheumo ( View Tweet)
Dr Furer on immunogenicity of Pfizer vaccine in RMD. Most good responses. GC, rituximab, MMF, abatacept blunt response. @RheumNow #EULAR2021 Abstr#LB0003 https://t.co/Lq4kx7B5bJ
Richard Conway RichardPAConway ( View Tweet)
Reader beware: Interpretation of relative effectiveness & safety of JAKi vs bDMARDs in real world data
POS0093 JAK-pot
heterogeneity between countries with variable safety @RheumNow @eular_org #EULAR2021
19 registries >700 JAK RA Rx markedly diff d/c due to AEs https://t.co/jFgN8NVx8v
Janet Pope Janetbirdope ( View Tweet)
Comparative effectiveness in RWD of retention of #tofacitinib vs #bDMARDs Equal d/c of Tofa and TNFI in RA in OBRI and Rhumatdata, Canadian databases
OP0179 #EULAR2021 @RheumNow @eular_org
1/3 in each group d/c Rx. Some other studies show retention better on JAKi than bDMARDs.
Janet Pope Janetbirdope ( View Tweet)
Real world data comparing #TNFi to nonTNFi Effectiveness in US RISE registry >16000 pts OP0117 No diff in DAS in RA between TNFi and non TNFi use
Diff ethnicities may make a difference & SES factors. So interpretation of diff registries may show diff results @RheumNow @eular_org
Janet Pope Janetbirdope ( View Tweet)
More zoster but ⬆️serious infections also in >3700 RA pts from BIOBASDER comparing #JAKi to #bDMARD. ? Due to later line Rx w JAKi? This is diff from some registries/ real world data wher other than HZ, serious infections are equal. OP0123 @RheumNow @eular_org
Janet Pope Janetbirdope ( View Tweet)
Smog makes arthritis flare! Study of air pollution & flares in 888 RA pts. With higher air pollution, 70% ⬆️risk of ⬆️CRP. Pts Nitric oxide exposed cumulative over 60 days had higher DAS but <5% of drug changes explained by air pollution. OP0178 @RheumNow @eular_org #EULAR2021
Janet Pope Janetbirdope ( View Tweet)
Comorbidities in RA ⬇️response at 6 months with first bDMARD! 501 pts with 1098 bDMARDs Rx. Presence of baseline comorbidities predicted poor response & worse if ⬆️comorbidities. OP0299 @eular_org @RheumNow #EULAR2021 https://t.co/P9pYf93NXw
Janet Pope Janetbirdope ( View Tweet)
Make sure #SLE pts with > 5 yrs of #Plaquenil get their regular FULL retinal screening. Retinal toxicity 6.8% for HCQ>5 years. risks seem to be cumulative dose, higher daily dose in users >5 yrs OP0133 @eular_org @RheumNow #EULAR2021 https://t.co/mVCdMxA2LX
Janet Pope Janetbirdope ( View Tweet)
Does she or doesn’t she have swollen jts during telemed call? Referred pts with suspected IA marked swollen jts on a mannequin. In 1637 pts 3/4 marked 1 or more jts ~41% had SJC by Rheum exam. Sens 87% but spec only 31%. Reasonable screen. POS1418 @RheumNow @eular_org #EULAR2021
Janet Pope Janetbirdope ( View Tweet)
What costs more in #SLE? Hospitalization for lupus nephritis or for mental health? @RheumNow @eular_org #EULAR2021 POS0304
Janet Pope Janetbirdope ( View Tweet)
Can I use #Rituximab during #pandemic? Ritux blunts response to #SARSCoV2 #vaccine LB0003 & worse outcomes vs other Rheum meds (also pred) from Global Rheum Alliance OP0006 but pts on Rituximab have worse disease ~ANCA vasculitis& diff to Rx RA. @RheumNow @eular_org #EULAR2021
Janet Pope Janetbirdope ( View Tweet)