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What Worries You, Masters You (7.1.2022)
Dr. Jack Cush reviews recent news, regulatory and guideline updates from the past week on RheumNow.com. Studies on methotrexate use, COVID vaccination, Supplements and vitamins, and arthrocentesis despite anticoagulation are discussed.
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Novel Anti-TNF Shines in Rheumatoid Arthritis Trial
MedPage Today
A new way of inhibiting tumor necrosis factor (TNF) for treating rheumatoid arthritis showed strong results in a phase II/III clinical trial, researchers said.
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Placebo Works Best in Combination
Analysis of two large clinical trial datasets shows that placebo response rates in randomised controlled trials (RCTs) of patients with rheumatoid arthritis are better when the patient continued background methotrexate (MTX).
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Study of IV CTX (n 13) vs mepolizumab (n 7)(MPZ; IL-5 inhib) in severe eosinophilic granulomatosis polyangiitis. BVAS & EOS# equal at mo 1 & 6, but MPZ had better retention(61 vs 5%) & less AEs (29% vs 54%) https://t.co/7s38a67C1r https://t.co/oXLb1ctoc7
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Dr. John Cush RheumNow ( View Tweet)
New Updated GRAPPA Psoriatic Arthritis Recommendations
The GRAPPA treatment recommendations have been updated and the 2021 evidence-based guidance is rich in treatment recommendations based on the key disease "domains." A great reference to print & carry.
https://t.co/0K8LP3LA9j https://t.co/1fJlzPKLWl
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Dr. John Cush RheumNow ( View Tweet)
JAMA Clinical Review 15 min podcast on treatment of carpal tunnel syndrome and trigger finger and common hand problems in clinical practice; featuring Drs. Mary M. McDermott, and Kelly Currie https://t.co/IhD6iqVyqC https://t.co/aChPLIbuEu
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Dr. John Cush RheumNow ( View Tweet)
The EMA's CHMP has positively recommended upadacitinib for use in Non-radiographic axial spondyloarthritis (nr-axSpA) based on Phase 3 SELECT-AXIS 2 study showing superior ASAS40 responses at week 14 https://t.co/uc7oOKglLX https://t.co/yz7M8U3rkk
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Dr. John Cush RheumNow ( View Tweet)
JAMA Patient Page on "What is Carpal Tunnel Syndrome ? A great patient resource, full read with graphics https://t.co/lL9209YpdL https://t.co/28ceu2obma
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Dr. John Cush RheumNow ( View Tweet)
ššØPossible future avenues for myositis therapeutics: DM,IMNM&IBM
Current treatment options in IIM management
1st line:GC+
Skinā”ļøMTX/AZR/MMF
Muscleā”ļøAZR/MMF/MTX
Lungā”ļøAZR/MMF
Dysphagia/Diaphragmatic weaknessā”ļøIVIG
RP-ILDā”ļøIVIG+CNI+CYC/RTX
Calcinosisā”ļøJAKi
https://t.co/G3vN055Gyq https://t.co/Qy9MULgeMs
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EnvisionRheumat ERheumat ( View Tweet)
Idiopathic inflammatory myopathies, Camille Rasmussen #BJHM #MedEd #FOAMed #Medtwitter #Myopathy #rheumtwitter #MedStudentTwitter https://t.co/dsqwHIAqnX
Brown Journal of Hospital Medicine BrownJHM ( View Tweet)
Are you an Expert in Still's disease, Periodic Fevers, FMF or Autoinflammatory Dz? We will add you to our expert referral listing. DM me to get on the list! https://t.co/hCkC1Yu9Nh
Dr. John Cush RheumNow ( View Tweet)
Novel Anti-TNF Shines in Rheumatoid Arthritis Trial
A new way of inhibiting tumor necrosis factor (TNF) for treating rheumatoid arthritis showed strong results in a phase II/III clinical trial, researchers said.
https://t.co/fTmWeIrVD5 https://t.co/LPk2Ok2gac
Links:
Dr. John Cush RheumNow ( View Tweet)
Placebo Works Best in Combination
Analysis of two large clinical trial datasets shows that placebo response rates in randomised controlled trials (RCTs) of patients with rheumatoid arthritis are better when the patient continued background MTX.
https://t.co/JmNGRQWv6L https://t.co/77LdcTwCvl
Links:
Dr. John Cush RheumNow ( View Tweet)
New Updated GRAPPA Psoriatic Arthritis Recommendations
The GRAPPA treatment recommendations have been updated and the 2021 evidence-based guidance is rich in treatment recommendations based on the key disease "domains."
https://t.co/PkDofio1eh https://t.co/kp6UEgwonV
Links:
Dr. John Cush RheumNow ( View Tweet)
Video: Post Hoc Analysis of the ORAL Surveillance Study
https://t.co/PVzfYlzdQa https://t.co/0RpA3CfTEE
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Dr. John Cush RheumNow ( View Tweet)
Gabapentin Implicated in Overdose Deaths
Recent FDA and MMWR warnings suggest that gabapentin was present in almost 10% of US overdose deaths between 2019 & 2020. The report also stated that gabapentin was the cause of the death in half of these cases.
https://t.co/ilNAd7ifdZ https://t.co/5GIcySXSDZ
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Dr. John Cush RheumNow ( View Tweet)
No science to F/U visit scheduling. Study of 114 outpt SpA visits, 34% considered unnecessary (fewer Rx change 15 v 52%) & clinical actions (23 v 63%) visits) vs. "necessary" visits (predict by ASDAS ā„2.1 & PtGA ā„3 >80%). Remote monitoring role? https://t.co/J8TIQRb0LG https://t.co/TCSN0NaeC8
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Dr. John Cush RheumNow ( View Tweet)
Video: Cancer after Biologic Use in Patients with a History of Prior Malignancy
https://t.co/jr37Ti7c9J https://t.co/iYCXzhXD44
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Dr. John Cush RheumNow ( View Tweet)
Study of contoured foot orthoses vs sham shoe insoles in 1st MTP #OA pain: 87 pts completed 12 wk trial that showed no differences in 1st MTP walking pain or other 2nd outcomes. Hard orthoses are no more effective than flat sham insoles https://t.co/XAFWwpSjHm https://t.co/g5J9TbG2pQ
Links:
Dr. John Cush RheumNow ( View Tweet)
Study of IV CTX (n 13) vs mepolizumab (n 7)(MPZ; IL-5 inhib) in severe eosinophilic granulomatosis polyangiitis. BVAS & EOS# equal at mo 1 & 6, but MPZ had better retention(61 vs 5%) & less AEs (29% vs 54%) https://t.co/YqfOu0X3jY https://t.co/fPBzogQFal
Links:
Dr. John Cush RheumNow ( View Tweet)
