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Practical tip from #EULAR2021 Pres6882: The difference a double bond makes: ⭐️Omega-3: Anti-inflammatory! ⭐️Omega-6: Pro-Inflammatory The ratio of ⬆️ omega-3 : ⬇️ omega-6 is key to anti-inflammatory diet @Rheumnow https://t.co/RtGWsDIouC
Eric Dein ejdein1 ( View Tweet)
A giant in our field. He has been my teacher for most of my career (since fellowship). He taught me how to care for patients, conduct research, & teach. My favorite quote is "If you're doing nothing, you're not doing anybody any good!" What is something he taught you? @rheumnow https://t.co/Fyw1u8wln8

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k dao KDAO2011 ( View Tweet)

Would you use #Telemedicine (TM) to follow-up #SLE patients post #COVID? Dr So showed in an RCT (N=122),patient satisfaction and time-to-review were better in TM vs Face-to-Face. Although none had COVID, >pts in TM were hospitalised and trend to⬆️FU #EULAR2021 #POS1164 @RheumNow https://t.co/p7aWv4AVm7
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
@almirall_m I don't monitor routinely. High rate of seroconversion post-TNFi but only small cases of TNFi-induced SLE (mild mostly). To screen with ANA if develop SLE features

Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)

Apremilast in Behcet’s - RELIEF European subgroup analysis ⬇️oral ulcer count, ulcer pain, disease activity ⬆️QoL ⭐️results consistent with general population Abs#POS0254 #EULAR2021 @RheumNow https://t.co/NVGt4TjkYY
Robert B Chao, MD doctorRBC ( View Tweet)
Dr Marsman presents positive RCT of Rituximab in PMR. GC-free remission 48% vs 21% (p=0.049) GC<=5mg 100% vs 47% (p=0.005) @RheumNow #EULAR2021 Abstr#POS0343 https://t.co/tjkKTS6DMN
Richard Conway RichardPAConway ( View Tweet)
Gut dysbiosis linked to worse disease status in AxSpA ⭐️higher dysbiosis associated w/ worse EvalGlobal, ASDAS-CRP, BASDAI, BASFI, VAS pain ⭐️comparing dysbiosis vs. non-dysbiosis group - significant difference in BASDAI, BASFI, EvalGlobal Abs#POS0237 #EULAR2021 @RheumNow

Robert B Chao, MD doctorRBC ( View Tweet)

Looking at those results (distributed evenly each side of 'maybe a little') it seems we're collectively uncertain right now about what JAK1 selectivity really means in practice. Hopefully we get stronger clinical insights (toxicity/efficacy) in coming years! #EULAR2021 @RheumNow https://t.co/jFhVGqpOnb

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David Liew drdavidliew ( View Tweet)

LNA043 - modified, recombinant human angiopoietin-like 3 (ANGPTL3) protein ⭐️proof of concept trial on patients with articular cartilage lesions ⭐️regeneration of damaged cartilage ⭐️treatment effect in cartilage volume ⭐️phase IIb pending Abs#POS0277 #EULAR2021 @RheumNow

Robert B Chao, MD doctorRBC ( View Tweet)

Which biomarkers could guide csDMARDs tapering in #RA patients in #remission? Dr Gul reported in a cohort study using a tapering protocol, 35% had relapsed. Risk score for sustained remission comprise IRC<2%, MSK-US PD=0 and RAQoL=<1 (AUC=0.89) #EULAR2021 #OP0182 @RheumNow https://t.co/y1Y6ug7f3w
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
How does MTX affect kidney function/adverse events? Pre-specified analysis of DBRCT: MTX 15-20mg/wk (n=2391) vs. PBO (n=2395) both with folic acid over median f/u 23 months ✅We demonstrated kidney safety of MTX ⚡️⚡️Also a *suggestion* of LESS decline in eGFR for MTX than PBO https://t.co/SZXloLRmnj

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Jeffrey Sparks MD MMSc jeffsparks ( View Tweet)

Due to significant interest in our Tweet about #POS0204 #EULAR2021, let's vote. Would you monitor #ANA in patients receiving therapy with #TNF inhibitors?🧐@RheumNow

Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)

#EULAR2021 #6899 Dr. Hovius: "Erythema migrans is a clinical diagnosis. If you suspect it, you should not order tests, you should prescribe antibiotics to treat the disease." Remember serologies are negative in early disease! @Rheumnow

Eric Dein ejdein1 ( View Tweet)

#EULAR2021 POS0105: Predictors of flare in SLE low disease activity state: ⭐️Ongoing glucocorticoid treatment ⭐️Ongoing immunosuppressant treatment ⭐️Anti-RNP antibody @RheumNow

Eric Dein ejdein1 ( View Tweet)

PS0103 #EULAR2021. Do you adjust complement levels by time of pregnancy? ⭐️Mean C3 ⬆️28% compared to 1st trimester ⭐️Mean C4 ⬆️ 11% compared to 1st trimester @RheumNow

Eric Dein ejdein1 ( View Tweet)

#EULAR2021 POS0227 recs all patients try subQ MTX before bDMARD. Mirza et al: ⬆️ efficacy & ⬇️side effects with subQ. May not be for all pts, but subQ ⬆️ efficacy than high-dose PO MTX. ⬇️ GI side effects, but ⬆️ ulcers/hair loss (use folate/leucovorin for this) @RheumNow

Eric Dein ejdein1 ( View Tweet)

Yesterday at #EULAR2021: Spacing trial: success in taper anti-TNF for stable SpA. POS0229 C-OPTIMSE study: Certolizumab w/d for SpA remission (continue full dose vs. 1/2 dose vs. placebo). Placebo group had ⬆️ activity scores, 77% flared. Ok to taper, but won't stop Rx @Rheumnow

Eric Dein ejdein1 ( View Tweet)

#EULAR2021 POS0230: TNFi changes intestinal microbiota in IBD-SpA ⬇️ Proteobacteria ⬆️Lachnospiraceae, Coprococcus Does inflammatory changes by TNFi restore intestinal eubiosis and does this affect SpA outcomes? @Rheumnow

Eric Dein ejdein1 ( View Tweet)

#EULAR2021 OP0291 proposes focus score of 4+ as prognostic factor for lymphoma risk in Sjogrens Focus score 4+: ⬆️lymphoma risk ⬆️salivary gland swelling ⬆️autoantibodies ⬇️thyroiditis Authors propose 4yr follow-up biopsy in all pts Focus score 4+. @RheumNow

Eric Dein ejdein1 ( View Tweet)

#EULAR2021 LB0001. Mavrilimumab (blocks GM-CSF alpha) phase2 trial in non-vented patients w/ #COVID19 : ⭐️⬇️ mortality and ventilation at day 29 ⭐️61% reduction in death (HR 0.39) ⭐️No drug related SAEs, no dose-related AEs @Rheumnow https://t.co/9UOi3xF7Re
Eric Dein ejdein1 ( View Tweet)
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