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Poster #POS0633 detailed HUR-BIO PsA pts started bDMARDs w/in 18 months of dx vs, on ave, 3x longer to start bDMARDs in RA pts in real life data. What do you drugs do you start in your PsA pts after dx? Feel free to detail me below! #EULAR2021 @RheumNow
Dr. Rachel Tate uptoTate ( View Tweet)
“Let thy food by thy medicine and thy medicine be thy food”
Western diet - greatest enemy of chronic inflammatory conditions?
⬆️salt
⬆️refined carbs
⬆️omega 6 fatty acids
⬇️fiber, long chain omega 3 FA
Abs#OP6882
#EULAR2021 @RheumNow
Robert B Chao, MD doctorRBC ( View Tweet)
Dr Schapp on nasal Staph Aureus eradication in ANCA vasculitis. Neither the presence or eradication of Staph Aureus appeared to influence the vasculitis @RheumNow #EULAR2021 Abstr#POS0249 https://t.co/bxtaznejNk
Richard Conway RichardPAConway ( View Tweet)
Practical tip from #EULAR2021 Pres6882: The difference a double bond makes:
⭐️Omega-3: Anti-inflammatory!
⭐️Omega-6: Pro-Inflammatory
The ratio of ⬆️ omega-3 : ⬇️ omega-6 is key to anti-inflammatory diet
@Rheumnow https://t.co/RtGWsDIouC
Eric Dein ejdein1 ( View Tweet)
A giant in our field. He has been my teacher for most of my career (since fellowship). He taught me how to care for patients, conduct research, & teach. My favorite quote is "If you're doing nothing, you're not doing anybody any good!" What is something he taught you? @rheumnow https://t.co/Fyw1u8wln8
k dao KDAO2011 ( View Tweet)
Would you use #Telemedicine (TM) to follow-up #SLE patients post #COVID? Dr So showed in an RCT (N=122),patient satisfaction and time-to-review were better in TM vs Face-to-Face. Although none had COVID, >pts in TM were hospitalised and trend to⬆️FU #EULAR2021 #POS1164 @RheumNow https://t.co/p7aWv4AVm7
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
@almirall_m I don't monitor routinely. High rate of seroconversion post-TNFi but only small cases of TNFi-induced SLE (mild mostly). To screen with ANA if develop SLE features
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Apremilast in Behcet’s - RELIEF European subgroup analysis
⬇️oral ulcer count, ulcer pain, disease activity
⬆️QoL
⭐️results consistent with general population
Abs#POS0254
#EULAR2021 @RheumNow https://t.co/NVGt4TjkYY
Robert B Chao, MD doctorRBC ( View Tweet)
Dr Marsman presents positive RCT of Rituximab in PMR. GC-free remission 48% vs 21% (p=0.049) GC<=5mg 100% vs 47% (p=0.005) @RheumNow #EULAR2021 Abstr#POS0343 https://t.co/tjkKTS6DMN
Richard Conway RichardPAConway ( View Tweet)
Gut dysbiosis linked to worse disease status in AxSpA
⭐️higher dysbiosis associated w/ worse EvalGlobal, ASDAS-CRP, BASDAI, BASFI, VAS pain
⭐️comparing dysbiosis vs. non-dysbiosis group - significant difference in BASDAI, BASFI, EvalGlobal
Abs#POS0237
#EULAR2021 @RheumNow
Robert B Chao, MD doctorRBC ( View Tweet)
Looking at those results (distributed evenly each side of 'maybe a little') it seems we're collectively uncertain right now about what JAK1 selectivity really means in practice.
Hopefully we get stronger clinical insights (toxicity/efficacy) in coming years!
#EULAR2021 @RheumNow https://t.co/jFhVGqpOnb
David Liew drdavidliew ( View Tweet)
LNA043 - modified, recombinant human angiopoietin-like 3 (ANGPTL3) protein
⭐️proof of concept trial on patients with articular cartilage lesions
⭐️regeneration of damaged cartilage
⭐️treatment effect in cartilage volume
⭐️phase IIb pending
Abs#POS0277
#EULAR2021 @RheumNow
Robert B Chao, MD doctorRBC ( View Tweet)
Which biomarkers could guide csDMARDs tapering in #RA patients in #remission? Dr Gul reported in a cohort study using a tapering protocol, 35% had relapsed. Risk score for sustained remission comprise IRC<2%, MSK-US PD=0 and RAQoL=<1 (AUC=0.89) #EULAR2021 #OP0182 @RheumNow https://t.co/y1Y6ug7f3w
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
How does MTX affect kidney function/adverse events? Pre-specified analysis of DBRCT: MTX 15-20mg/wk (n=2391) vs. PBO (n=2395) both with folic acid over median f/u 23 months
✅We demonstrated kidney safety of MTX
⚡️⚡️Also a *suggestion* of LESS decline in eGFR for MTX than PBO https://t.co/SZXloLRmnj
Jeffrey Sparks MD MMSc jeffsparks ( View Tweet)
Due to significant interest in our Tweet about #POS0204 #EULAR2021, let's vote. Would you monitor #ANA in patients receiving therapy with #TNF inhibitors?🧐@RheumNow
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
#EULAR2021 #6899 Dr. Hovius: "Erythema migrans is a clinical diagnosis. If you suspect it, you should not order tests, you should prescribe antibiotics to treat the disease." Remember serologies are negative in early disease!
@Rheumnow
Eric Dein ejdein1 ( View Tweet)
#EULAR2021 POS0105: Predictors of flare in SLE low disease activity state:
⭐️Ongoing glucocorticoid treatment
⭐️Ongoing immunosuppressant treatment
⭐️Anti-RNP antibody
@RheumNow
Eric Dein ejdein1 ( View Tweet)
PS0103 #EULAR2021. Do you adjust complement levels by time of pregnancy?
⭐️Mean C3 ⬆️28% compared to 1st trimester
⭐️Mean C4 ⬆️ 11% compared to 1st trimester
@RheumNow
Eric Dein ejdein1 ( View Tweet)
#EULAR2021 POS0227 recs all patients try subQ MTX before bDMARD. Mirza et al: ⬆️ efficacy & ⬇️side effects with subQ.
May not be for all pts, but subQ ⬆️ efficacy than high-dose PO MTX. ⬇️ GI side effects, but ⬆️ ulcers/hair loss (use folate/leucovorin for this)
@RheumNow
Eric Dein ejdein1 ( View Tweet)
Yesterday at #EULAR2021: Spacing trial: success in taper anti-TNF for stable SpA. POS0229 C-OPTIMSE study: Certolizumab w/d for SpA remission (continue full dose vs. 1/2 dose vs. placebo). Placebo group had ⬆️ activity scores, 77% flared. Ok to taper, but won't stop Rx @Rheumnow
Eric Dein ejdein1 ( View Tweet)