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Low Risk of Malignancy with Secukinumab

d Jack Cush, MD

Analysis of ongoing safety from the secukinumab (SEC) drug development program shows a low risk for malignancy in SEC patients treated for up to five years for either psoriasis, psoriatic arthritis (PsA) or ankylosing spondylitis (AS).

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DMARD Dropouts During COVID-19

d Jack Cush, MD

A full year from the onset of the SARS-COV-2 pandemic, rheumatologists are still seeing the consequences of COVID, with many patients avoiding usual care, follow-up visits, routine lab testing and with many self-stopping their antirheumatic meds, because it seemed like the right thing to do.

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Coverage from Dr. Robert Chao ( @doctorRBC) from #RNL2021 #RheumNow "How do you treat RA pts with persistent pain? Dr. Alan Matsumoto - “We have to understand that there may be other pathways of pain besides inflammatory”

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News Feature: Anti-inflammatory Diet Control of Rheumatoid Arthritis https://t.co/fvOW9MeTTY https://t.co/6MZsFEC5aJ

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Thanks @uptoTate for sharing this great quote from #RNL2021 "Dactylitis to me is enthesitis and synovitis in the same digit." Dr. A. Kavanaugh #RNL2021"

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Did you get a chance to listen to last week's podcast?#RheumNow Mistakes with Steroids https://t.co/qHtiyTzQme https://t.co/RI5XnZOmV2

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News Feature: GLP-1 Therapy in Knee Osteoarthritis Knee osteoarthritis (KOA) is best managed by weight loss, as the effects of most analgesic therapies have been marginal and debatable. https://t.co/0YB5rOuJiD #RheumNow https://t.co/LEFUBTlJq4

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Med nonadherence is universal 1) at 1 yr, only 48% pts still take their statins, 2) 1 in 4 pregnant asthmatics dont take their inhaled corticosteroids,. 3) half of psychiatric pts don’t take their psychotropic meds. What are the reasons for noncompliance? https://t.co/OBAfbFLIO9

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Study of 26 patients with chronic inflammatory cdiseases vaccinated with mRNA vaccines showed all with considerable immunogenic responses. No unexpected side effects seen and No flares of the underlying inflammatory disease was seen. https://t.co/7Q5bYp5A9i

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News Feature: Overview of New VEXAS Syndrome Medscape offers up an informative overview of the newly described syndrome called VEXAS discovered by researchers at the National Institutes of Health. https://t.co/9oDtahJ9yI #RheumNow https://t.co/5yBiiRPWb3

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RT from @KDAO2011"When Ustekinumab was developed, it was accidental that the p40 subunit targeted blocked both IL-12 and IL-23 (original intent to block only IL23) blocking I12 may decrease response to IL-23. this drug is better for skin than for joints - Dr. E Ruderman #RNL2021

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News Feature: Can Targeting RANKL in RA Heal Erosions? Treatment with denosumab (Prolia) helped heal bone erosions over 2 years among patients with rheumatoid arthritis whose disease activity was well controlled, researchers reported. https://t.co/kpYozqR8vD #RheumNow https://t.co/m0SjJzfp8m

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RT from @doctorRBC covering #RNL2021 -------- Make sure to screen your PsO and PsA for depression and mental health. Worsening depression can cause emotional stress, leading to worse disease. #RNL2021 #rheumnow

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News Feature: Implementing Smoking Cessation Programs #RheumNow https://t.co/wEBZRd3n8Q https://t.co/c5yfIyl2Vc

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#RNL2021 Tweet from @uptoTate 2020 (contact) allergen of the year: Essential Oils! Keep on using 'em in order to put your family-friendly dermatologist's kids through school! Melodie Young, NP #RNL2021

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11 RCTs (4,329 pts) & 19 registries (9,739 pts) studied Rx efficacy in CTD pts w/ pulmonary HTN. Overall, Rx (Sildenafil, Treprostinil, Bosentan, etc) reduced mortality 36% vs controls. CTD‐PAH survival was lower (52% v 72%) vs PAH; higher after 2010 https://t.co/IFb3nLiJbL

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New podcast available--Mistakes with Steroids Dr Jack Cush gives his spin on this week's news featured on RheumNow. Download wherever podcasts are available. https://t.co/cUI65I9759 https://t.co/fOWJXW50nI

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HLA-B27 status does not change the risk of COVID-19 in spondyloarthritis patients. Survey of 3435 SpA pts; shows 76% as HLA-B27 positive. COVID infx was thesame between B27 Pos & Neg pts (1.5% vs 1.4%) and severity was also the same https://t.co/qavodFynr0

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Axial Involvement in SpA: A Patient-Centered Exploration Sponsored by Novartis Medical Affairs Listen to Ethan Craig, MD, MPH present insights from patient cases to distinguish axial involvement within the spectrum of SpA. https://t.co/o2q5pTP3WD https://t.co/IXHs0LHSOe

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#RNL2021 coverage from @DrPetryna Refractory RA by Dr. Buch: -active DZ after >2 b/ts DMARDs -why rfRA exists: ?Immunologic heterogeneity of RA ?contributing co-morbidities ?unidentified Rx target -effective Rx in early disease decreases risk of future rfRA" https://t.co/ecrbqlvemf
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