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Rituximab in Systemic Sclerosis?

d Jack Cush, MD

No drug is FDA approved to manage the skin or joint complaints of systemic sclerosis (SSc); a recent metanalysis suggests that rituximab may improve skin score and disease activity indices (DAS, mRSS) while stabilizing organ involvement in SSc patients.

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RheumNow Podcast – Upadacitinib Wins in PsA (4.2.2021)

d Jack Cush, MD

Dr Jack Cush reviews the news and Journal reports and takes "Back Talk" questions from viewers.

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US Senate Introduces the Safe Step Act

d ACR

The American College of Rheumatology (ACR) today commended leaders in the United States Senate for introducing the bipartisan Safe Step Act of 2021 (S. 464), new legislation that would place reasonable limits on insurer use of step therapy.

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Upadacitinib Clinical Efficacy in Psoriatic Arthritis

d Jack Cush, MD

McInnes and colleagues have published the results of the SELECT - PsA trial in NEJM showing updacitinib (UPA) to be superior to placebo in active psoriatic arthritis (PsA) patients, with 15 mg UPA equal to adalimumab (ADA) and 30 mg UPA qd being superior to ADA.

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Interestng overview/read on the Inflammasome - its history, clinical targeting and new inflammasome (NLRP3) inhibitors in development by pharma. https://t.co/DEdP09GZd7

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Dr. John Cush RheumNow ( View Tweet)

Are you signed up for the RheumNow daily newsletter? Head over to RheumNow and sign up to have the news delivered to your inbox daily. https://t.co/HSBjF6ySNv

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#RNL2021 coverage from @uptoTate "Dr. Robert Wang: 91% of uveitis is non-infectious and located in the front of the eye - "anterior uveitis/iritis." 50% of anterior uveitis patients are +HLA B27! " #RheumNowLive

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News Feature: Upadacitinib Clinical Efficacy in Psoriatic Arthritis https://t.co/gdAnqEFk3n https://t.co/PNYwhRFTEK

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Thanks @doctorRBC for sharing this from #RNL2021 "Dr. N Haroon talking about SpA treatment -TNFi can reduce spinal radiographic progression -Better to taper biologics in AxSpA than stopping -JAKinibs are coming "

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News Feature: HLA B27 Iritis - RNL 2021 Highlights by Dr. Rachel Tate ( @uptoTate ) #RNL2021 #RheumNow https://t.co/SlftHnhD6z https://t.co/utjOU0rfBP

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News Feature: Inflammatory Conditions Up the Risk of Premature Myocardial Infarction https://t.co/gbPpAYJGFg https://t.co/ValdJWGyxl

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News Feature: Aortic Calcification and Lumbar Fracture Risk in Older Men https://t.co/6gcoP9EFey #RheumNow https://t.co/BTTrYAoyNp

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In the UK, NICE has recommended Kineret (anakinra) for use as 1st line biologic Rx in systemic JIA and adult-onset still’s disease (AOSD); but pts must first fail a DMARD - the latter is unfortunate as systemic Sxs of Still's do not respond to usual DMARDs.https://t.co/BNdqhLy9jg

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From @doctorRBC #RNL2021 coverage "Avoid the lawsuit... “warty” appearing skin lesions in a lupus can be confused as skin cancer on shave biopsy when in fact it could be VERRUCOUS LUPUS which can be treated with HCQ. Perform a deeper biopsy. - Dr. Clay Cockrell " #RheumNow

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Comparison of oral and parenteral MTX shows oral MTX in RA is non inferior to subcutaneous MTX treatment (in 640 RA pts) with regard to disease activity, but oral MTX had fewer adverse events than SC ( 41% vs 52%, p= 0.005). https://t.co/828kcG53iz

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Matched cohort Nurses’ Health Study looked at 283 pre‐RA pts (mean 9.7 years before RA Dx) and and 842 controls; 21% pre‐RA were ACPA+. ACPA+ was associated with increased risk of COPD (HR 3.04) that was not seen in ACPA- pts. https://t.co/HNB11eAiva

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Dr. Olga Petryna ( @drpetryna) weighing the future Rx in RA by Dr. Fleischmann: -CD22, new IL6i & GM-CSF show promises but far form being available -bDMARD or tsDMARD after MTX but work better wMTX -JAKS better choice for mono-therapy but safety is a concern #RNL2021

Dr. John Cush RheumNow ( View Tweet)

#RNL2021 coverage from @doctorRBC ACR’s conditional recommendations for tx of specific RA populations #RheumNow https://t.co/3uo9x42bPX
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Retrospective study of 267 adults w/ Henoch-Schönlein purpura (AKA IgA vasculitis (IgAV) shows more arthritis, enteritis & renal Dz, higher comorbidity scores (2.6 vs1.5) & higher risk of Serious infx (OR 8.4) and death (MRR 2.06) than gen population https://t.co/ihK6JPbLFm

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News Feature: Hypertension Unaffected by Urate Lowering Therapy Does uric acid contribute to the risk of hypertension (HTN)? A recent cohort trial shows that allopurinol in young adults does not sufficiently lower blood pressure (BP). https://t.co/PAMkgCc2DS #RheumNow https://t.co/ar7OiWKVQj

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