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Combo Anti-Spike Protein Antibody for Mild to Moderate COVID-19

d Jack Cush, MD

JAMA has published the BLAZE-1 study, showing significant SARS-CoV-2 viral load reduction at day 11 and less COVID-19 progression when combination anti-spike monoclonal antibody therapy (bamlanivimab and etesevimab) was given to mild to moderate, non-hospitalized COVID-19 patients.

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TB.EMimage.CDC_.jpg

Low Risk of TB with Secukinumab

d Jack Cush, MD

JAMA Dermatology has reported on a longitudinal cohort study of 12,319 secukinumab (SEC) treated patients (psoriasis, psoriatic arthritis, or ankylosing spondylitis); no new cases of active tuberculosis (TB) and very few cases of latent tuberculosis infection (LTBI) were f

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ILD damage fibrosis path

Mortality Risk in Rheumatoid Lung Patients

d Jack Cush, MD

A Medicare claims analysis of rheumatoid arthritis (RA) patients showed that RA-associated interstitial lung disease (RA-ILD) was seen in nearly 5% of patients and was found to increase mortality risks, including respiratory and cancer mortality not explained by other factors.

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NEW QD Clinic Differential Dx Myalgias & Arthralgias https://t.co/ozawoe6RMO

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Dr. John Cush RheumNow ( View Tweet)

Denosumab inhibiting osteolysis? 22 pts undergoing revision THR surgery for osteolysis, 10 Rx w/ denosumab had 83% fewer osteoclasts @ osteolysis membrane–bone interface. Proof concept: DEN may have osteoclast effects at implant interface https://t.co/dJ06rk0SR3

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Dr. John Cush RheumNow ( View Tweet)

Ehlers-Danlos Syndrome pts have higher association with GI conditions (IBS, etc OR =3.57), POTS & Autonomic dysfunction (OR=4.4), food allergy (OR= 3.9), CV complications (OR 6.1; MV dx, aortic aneurysm), longer hospitalizations (OR= 1.76) https://t.co/noobvrx0cQ

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Dr. John Cush RheumNow ( View Tweet)

Though provoking piece by Dr. Len Calabrese in Healio,He references Drs. Schett and Scher writing in Nature Reviews Rheumatology on KOLs. Both articles are about reflection on what we do, how we do it, what motivates us. Good Reads https://t.co/HDlFRVJq1a https://t.co/CtqqiZuxwo

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Dr. John Cush RheumNow ( View Tweet)

Swedish Armed Forces study suggests the least fit are at greatest risk for developing psoriasis later inlife. From 1968 -2005 1,886,542 military recruits were followed mean 31 yrs. Low CV fitness showed higher rate of psoriasis (HR 1.35) and PsA (HR 1.44) https://t.co/52zTjMM24y

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Dr. John Cush RheumNow ( View Tweet)

Factors Predictive of SLE Flare After HCQ Taper/Discontinuation The benefits of hydroxychloroquine in lupus are many, but what if you were to withdraw HCQ? Read more: https://t.co/r5iDXBEuQP https://t.co/LImqA9y8Dn

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Dr. John Cush RheumNow ( View Tweet)
Epidemiologic study of #SLE from CDC & lupus registries estimates there are 204,295 SLE pts in USA (2018). Prevalence=72.8 SLE/100,000 and is 9 X higher in females than males (129 vs 14.6/100,000), especially among Ame Indians/Alaska Natives, Black females https://t.co/5yHVQ9UqZ4

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Dr. John Cush RheumNow ( View Tweet)

My note to the FDA staff: https://t.co/n2Pr2Kzrre
Dr. Janet Woodcock DrWoodcockFDA ( View Tweet)
Toci led to poorer outcomes in this study. Effect of tocilizumab on clinical outcomes at 15 days in patients with severe or critical coronavirus disease 2019: randomised controlled trial | The BMJ https://t.co/95zaq2CEUU

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Dr Philip Robinson philipcrobinson ( View Tweet)

UTSW Rheum Grand Rounds - IgG4 Dz - Plasmablasts may be a useful biomarker; but is not generally available in clinical labs (must be done on fresh whole blood) @UTSWIMchief https://t.co/GlEKw0KD3O
Dr. John Cush RheumNow ( View Tweet)
UTSW Rheum Grand Rounds - IgG4 Dz common lab findings: hypergammaglobulinemia is common but elevated ESR/CRP are not. Most have elevated IgG4 serum levels @UTSWIMchief https://t.co/wR5FEqZTsX
Dr. John Cush RheumNow ( View Tweet)
UTSW Rheum Grand Rounds - IgG4 Dz commonly presents as major salivary and lacrimal gland enlargement, orbital disease, autoimmune pancreatitis, retroperitoneal (mass) fibrosis or tubulointerstitial nephritis. @UTSWIMchief

Dr. John Cush RheumNow ( View Tweet)

UTSW Rheum Grand Rounds - IgG4 Dz renal involvement; most common is tubulointerstitial nephritis @UTSWIMchief https://t.co/q8dZbgmvfK
Dr. John Cush RheumNow ( View Tweet)
UTSW Rheum Grand Rounds - Dr. Andres Quiceno on "IgG4 related Disease" Histologic criteria req >40% on IgG4/IgG cells @UTSWIMchief https://t.co/2kOioCdFiM
Dr. John Cush RheumNow ( View Tweet)
Being "busy" is about priorties and productivity.

Dr. John Cush RheumNow ( View Tweet)

Inequities in Telemedicine During COVID-19 Health equity in the telehealth age has assumed added importance since the COVID-19 pandemic began but what if you don't have access to reliable technology? The problem spreads beyond that though. https://t.co/L8nvUbOqHA https://t.co/SZSmerQGEY

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Dr. John Cush RheumNow ( View Tweet)
Osteoporosis in Men - is often unrecognized till they fracture. Risk factors for OP in men: - Meds: steroids; PPI immunosuppressives - Chronic renal disease - Smoking, ^^alcohol - Sedentary lifestyle - Elderly - Family history: Osteoporosis https://t.co/V4P5wey070

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Dr. John Cush RheumNow ( View Tweet)

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