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Medicare's 'Most Favored Nation' Drug-Pricing Rule in Limbo

d MedPage Today

The fate of the Trump administration's "most favored nation" (MFN) rule for bringing down prescription drug prices remains uncertain as President-elect Joe Biden prepares to assume office later this month.

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RheumNow Podcast – Lights, Camera, Zoom (1.8.2021)

d Jack Cush, MD

Dr. Jack Cush reviews the news, journal articles and favorite blogs from this past week on RheumNow.com.

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Adherence to Hydroxychloroquine Lowers Lupus Mortality

d Jack Cush, MD

A lupus cohort study from British Columbia, Canada has shown that medication adherence with hydroxychloroquine (HCQ) is associated with a 71% to 83% lower mortality. 

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Rhapsody Study: IL-1 Inhibition in Recurrent Pericarditis

d Jack Cush, MD

Recurrent pericarditis is a rare, probable autoinflammatory disorder mediated by interleukin-1 (IL-1); and is often refractory to glucocorticoids and colchicine.

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EULAR Guidance on Patient Adherence to Meds

d Jack Cush, MD

Non-adherence may be the single most untold risk to suboptimal outcomes in the care of musculoskeletal disease.  It has been estimated that 30-80% of patients with rheumatic and musculoskeletal diseases (RMDs) are nonadherent to prescribed regimens.  EULAR has commissioned a task force

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Rhapsody Study: IL-1 Inhibition in Recurrent Pericarditis RHAPSODY was a phase 3 multicenter, double-blind, event-driven, randomized-withdrawal trial of rilonacept in 86 patients with recurrent pericarditis Read more: https://t.co/syibq4X7Ps https://t.co/gnxlpOGiHA

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EULAR Guidance on Patient Adherence to Meds--Non-adherence may be the single most untold risk to suboptimal outcomes in the care of musculoskeletal disease. https://t.co/XwxkFz66fv https://t.co/E6W3H56jps

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Petri et al shows higher HCQ levels associated with reduced thrombosis risk, study of 739 SLE pts - 38 patients (5.1%) had thrombosis. HCQ level lower in thrombosis pts (720 vs 935, p=0.025). 69% decr in VTE when levels >1068 ng/mL vs <648 ng/mL https://t.co/kis5zry7uH

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Head to RheumNow for our latest Covid-19 articles. https://t.co/TiB7739ONL

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New download available! H2H comparison chart. https://t.co/w7tQYXn0us

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Spinal Benefits Seen With Cosentyx in PsA---Secukinumab (Cosentyx) was effective for axial manifestations of psoriatic arthritis in a 52-week multicenter phase III study, investigators reported. https://t.co/OfkQtAO9Gh https://t.co/hs3NaBjLuF

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BASE: a controlled, ph 4 safety RCT of IV Belimumab (10 mg/kg) or PBO (+standard Rx) given to 4018 SLE pts over 48 wks. Found no increase in all-cause mortality and special AE: w/ very low event rates (SIE 3·75%, opportunistic infx 1·8%, cancers 0·25%) https://t.co/Zc5BqXQ038

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44 patient study of sirolimus vs placebo in patients with inclusion body myositis found no difference in the primary outcome of relative knee extension strength, nor in secondary outcomes. SAE were more common w/ sirolimus 45% vs 27% in PBO https://t.co/YhnRTnaGFl

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2021 Whatever it Takes Let me be blunt. If you’re still waiting for this whole COVID thing to be over with – you’re drifting, going nowhere and you’re setting yourself up for a long hard winter, spring and summer of 2021. Read more on the site. https://t.co/1y172EVpwV https://t.co/W1MAKzOCJS

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Nice Yale Medicine overview of MIS-C (multisystem inflammatory syndrome in children) due to COVID-19 https://t.co/oYOlJFHzuN

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COVID-19 Vaccination - Phase Ib Begins The U.S. Centers for Disease Control and Prevention (CDC) has issued a timeline guidance document on when, how and who should get the commercially available COVID-19 vaccines. https://t.co/7fGCnHJnvy https://t.co/AiBBW94kR5

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Broadalumab the other IL-17 inhibitor, is FDA approved for psoriasis. The AMVISION-1 & AMVISION-2 ph III trials in psoriatic arthritis showed in 962 PsA pts it was effective w/ week 16 ACR20 of ~46% (vs 21% PBO). AEs unremarkable w/ 1 case of depression https://t.co/zrsVD7N3Z9

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Hello 2021 and new drug price hikes - on average a 4.2% hike in over 500 drugs (past years saw an avg hike ~5%). Increases include Cosentyx 7%, Humira & Rinvoq 7.4%, Orencia 4.5%, Taltz 5%, Actemra 3%, Benlysta 5%, Xeljanz 4.9% & Cimzia 4%

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WooHoo. Got my 2nd Covid-19 vax shot. Now my B cells are in overdrive against the nasty COVID. Please get yours. ASAP https://t.co/rRj44GpJxl
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Study of 100 pts w/ Granulomatosis with polyangiitis finds 56% had elevated d-dimer levels and that d-dimer are associated with disease activity and inflammation rather than with the risk of venous thromboembolism. 23 had VTE not predicted by d-dimer https://t.co/zIYKXNl0oO

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