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RheumNow Podcast – Modern Treatment of RA Pregnancy (6.25.2021)

d Jack Cush, MD

Dr. Jack Cush reviews this week’s news and journal reports featured on RheumNow.com.

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Birthday Gatherings Increase COVID-19 Risk

d Jack Cush, MD

How risky are family gatherings, birthday parties and informal social gatherings? A cross-sectional analysis suggests that birthdays may be associated with increased rates of COVID-19 infection within households where there is a high COVID-19 prevalence in the population. 

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Knee Replacement in Obese OA is Cost Effective

d Jack Cush, MD

Debates over ideal candidates for total knee replacement (TKR) in osteoarthritis patients often excludes those who are obese, but a recent article in the Annals of Internal Medicine suggests that TKR is both effective and cost-effective in obese patients (BMI >40 kg/m2) with

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Analysis of Ph 3 data Tofacitinib in Ulcerative Colitis shows no increase in Cancer; rates equal to that seen w/ Tofa in RA, PsA & other biologics in UC. In 1124 pts (2576 PtYrs) there were 20 cancers, excluding NMSC (IR, 0.75; 0.46–1.16) https://t.co/xiTIKYAtyY

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Blindness with Tocilizumab in GCA: Is it a Worry? https://t.co/PJYap294jm https://t.co/q1izGlH68j

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EULAR 2021 Lupus Panel Drs. Cush, Dao, Pope, Dein and Yusof discuss a number of lupus presentations as well as abstracts presented at the virtual EULAR 2021 meeting. Lupus nephritis and treat-to-remission presentations were discussed by the panel. https://t.co/yUEXTOatpR

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Alcohol abuse worsens psoriasis. Prospective study of 266 Psoriasis pts (1/2 biologics; 1/2 ; conventional Rx). Poorer outcomes predicted by alcohol abuse (CAGE score) (regression co-efficient 1.40), obesity (1.84) & conventional Rx (4.39) https://t.co/CJGTT0HoV2

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Which patients with psoriasis are at risk to develop PsA? https://t.co/5sj5HSnke3 https://t.co/vxOHIUrevd

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FDA has granted emergency use authorization (EUA) for Actemra (tocilizumab) us in treating hospitalized COVID-19 (adults and kids) patients on steroids and who require, supplemental oxygen, mechanical ventilation, or ECMO https://t.co/YAVfbykcti https://t.co/d7pS1lUXpa

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The FDA has informed Abbvie that their supplemental application for new indications (PsA and AS) for upadacitinib (Rinvoq) has been delayed; the FDA citing its ongoing review of tofacitinibs safety concerns stemming from the ORAL Surveillance RA study https://t.co/sSJyVtQNYu

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Danish population study shows that all cause mortality in GCA is increased 49%,(RR 1.49; CI1.36-1.64) after 1 year but less so at 10 years (RR 1.03: 1.00-1.05). Deaths usually due to infectious, endocrine, cardiovascular, GI diseases https://t.co/p36zDskf6y

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RHEUMATOLOGIST SURVEY - on Osteoporosis, Osteomalacia and a Family Hx of recurrent Fractures - Answer a 4 question survey here >> https://t.co/TuY1fXAAk5

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Guidelines for the prevention, diagnosis and treatment of Lyme disease have been formulated by the ACR, Infectious Diseases Society of America and the American Academy of Neurology https://t.co/RgHzCLrtDM

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The Swedish Rheumatology Quality Register looked at risk of ant.uveitis (AU). From 4851 starting secukinumab (456) or TNFinhibitor (4395 ), there was higher AU risk w/ SEC (adj HR 2.32; 1.16-4.63) & ETN (1.82;1.13-2.93) (ADA as referent) https://t.co/j06MtKedYU

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Metanalysis shows no clear association between allopurinol use and a lowered all-cause mortality in gout patients, but the number of studies was small https://t.co/MM0nIjZPbV

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Italian survey foud 82% of MSK healthcare workers willing to receive COVID-19 vaccine, but only 55% of their rheumatic Dz patients were as willing, even if they perceived they were at risk. Not out of fear or distrust. more education needed https://t.co/nPhhME2dnC

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66 yoF w/ prurtitic rash, weakness, SOB, hyperpigmented papules over knuckles, periungual hemorrhages, shawl like rash and the Holster sign (lateral thighs). Which drugs would you use: A. Steroids B. IVIG C. MMF D. Baricitinib E. Plasmapheresis https://t.co/IA4qbGri5b

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Is there a connection between stress and the onset of RA? https://t.co/Oir9ZV3m7i https://t.co/GTpvTCiMAP

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Rheumatologist Survey - A man with osteoporosis and recurrent fractures - What should test for ? Phosphorous, testosterone, magnesium or HLA-B27; answer here> https://t.co/TuY1fXAAk5

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Miss out on something from EULAR? Check out our daily recaps. https://t.co/seKFd36te4 https://t.co/O1Of0ThRjS

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