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Ides of March (3.15.2024)

Jack Cush, MD

Dr. Jack Cush has advice for Caesar and the superstitious, and covers pregnancy, platelets, dialysis and vaccinations in Lupus.

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DMARD,trends,2021

US Trends in RA DMARD Use 2017-2021

Jack Cush, MD

A trend analysis of DMARDs shows that only half of rheumatoid arthritis (RA) patients are taking DMARDs, and that the COVID-19 pandemic substantially affected DMARD use. Despite numerous DMARD advances and evolving treatment guidelines since 1990, older therapies are still commonly used and the latest agents make up a small percentage of overall DMARD use.

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depression oh no HA

Again, a High Mortality with Depression and RA

Jack Cush, MD

Last week we reported on a Korean study showing a 66% elevated mortality risk in RA patients (n=38,487) with depression.

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Leflunomide

9 Facts about Leflunomide

Jack Cush, MD

Medscape has published an informative review of leflunomide, drawn from Dr. Eric Ruderman’s recent lecture on the subject at the February RWCS meeting in Maui.

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syringe, pill, DMARD, Treatment, therapy

JAMA Review of DMARD Use in Rheumatoid Arthritis

Jack Cush, MD

JAMA has reviewed the "2022 EULAR Recommendations for the Management of Rheumatoid Arthritis With Synthetic and Biological Disease-Modifying Antirheumatic Drugs". 

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Depression and RA (3.8.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news, journal reports and regulatory approvals from the past week.

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lonely,depression,man,HeadAche

Increased Depression on Rheumatoid Arthritis

Jack Cush, MD

A Korean nationwide cohort study found that both seropositive and seronegative rheumatoid arthritis (RA) patients have a significantly higher risk of depression. 

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arthritis,gout,autoimmune,Dx,lab

Polyautoimmunity in RA, Regardless of ACPA Positivity

Jack Cush, MD

While it is believed that autoimmunity follows autoantibody positivity, a Danish study shows the incidence of polyautoimmunity to be similar in rheumatoid arthritis (RA) patients who are either anticyclic citrullinated peptide antibody (ACPA)–positive or ACPA–negative. 

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many heads

19% Arthritis Prevalence in the USA

Jack Cush, MD

According to the National Health Interview Survey (NHIS), in 2022, the prevalence of diagnosed arthritis in adults was 18.9% (women 21.5%, more than men 16.1%). These numbers are down since the CDC's MMWR report of 2019–2021, where is was estimated 21.2% of U.S.

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JAMA Review of DMARD Use in Rheumatoid Arthritis JAMA has reviewed the "2022 EULAR Recommendations for the Management of Rheumatoid Arthritis With Synthetic and Biological Disease-Modifying Antirheumatic Drugs". https://t.co/fpAigPpKzv https://t.co/GkbqW2BxpA

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Again, a High Mortality with Depression and RA Last week we reported on a Korean study showing a 66% elevated mortality risk in RA patients with depression. This week, a new report shows depression in RA increases the mortality risk by more than 5 fold. https://t.co/C7Z7djny4S https://t.co/J9B6DUqcIC

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Dutch study of 586 RA pts on bDMARDs found more nonserious infections (NSIE) (77/100PYs) than serious infx (SIE)(1.3/100Pys). Upper respiratory tract infections were most frequent with recurrence rate that remained stable over time https://t.co/zwELL2yevG https://t.co/GLbidGvjp3

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DANBIO #RA registry study: in 21,982 Rx starts (96K PtYrs) saw 1423 cancers w/ no overall increase in cancer risk with tocilizumab, sarilumab, abatacept, or rituximab (HRs from 0.7–1.1). No diff betw ABA vs TNFi (HR 1.41) nor HEME CA RTX vs TNFi (HR 0.09) https://t.co/mIEqALnnwI https://t.co/N1v3TzuBGm

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Mixed Long-term Effects of Calcium and Vitamin D in Postmenopausal Women https://t.co/u2cf5hmTAE https://t.co/A4kdwG6eRm

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Dr. John Cush RheumNow ( View Tweet)
Depression and RA Dr. Jack Cush reviews the news, journal reports and regulatory approvals from the past week. https://t.co/nJZD4D2ByC https://t.co/ET3Xp9cK62

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Increased Depression on Rheumatoid Arthritis A Korean nationwide cohort study found that both seropositive and seronegative rheumatoid arthritis (RA) patients have a significantly higher risk of depression. https://t.co/9AtlBrDTUJ https://t.co/vKEhBfkHQD

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Dr. John Cush RheumNow ( View Tweet)
Starting MTX at higher or subcut. doses yields better ACR20 responses. Review of 12 trials & 1,566 pts, shows: - higher initial MTX 25 mg (but more GI AEs) - SC MTX more ACR20 resp (85% vs PO 77%) - MTX non-response, success w/ SC MTX https://t.co/01PuDpkUIF https://t.co/vXLWEp4srH

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COVIDs Extended Risk for Rheumatic Disease Annals of Internal Medicine reports a large, binational study finding SARS-CoV-2 infection was associated with an increased risk for AIRDs that extends up to 12 months after infection. https://t.co/HjQ56hiiny https://t.co/vvC3iVqNyF

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Have a Rheumatology question or case for Jack Cush? Record it here and we'll feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/a3XeAa2lcG https://t.co/dTZa2uQF97

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Polyautoimmunity in RA, Regardless of ACPA Positivity While it is believed that autoimmunity follows autoantibody positivity, a Danish study shows the incidence of polyautoimmunity to be similar in RA patients who are either ACPA + or -. https://t.co/7lmp1NB0XX https://t.co/onaEluzkGy

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Dr. John Cush RheumNow ( View Tweet)
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