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Towards personalized therapy in RA with @MeganHanlon4's work: the synovial macrophage sub-population CD206+CD163+ is significantly enriched in RA synovial tissue, correlated with disease activity and baseline levels predict response to therapy.
#EULAR2021 @RheumNow #OP0028
Aurelie Najm AurelieRheumo ( View Tweet)
Insights in RA and colon:
Naïve RA patients
-higher degree of intestinal permeability vs age and sex matched ctrls in colonic biopsies
-higher serum levels of bacterial translocation markers (LBP and CD14s); reduced in resp to DMARDs. #EULAR2021 @RheumNow #OP0035 @ClaireDaien
Aurelie Najm AurelieRheumo ( View Tweet)
Can we taper IV belimumab in #SLE? Dr Fredi reported 14/48 (29%) extended tx to at least 5-weekly after 12mo of tx. No worsening C3/C4 & PGA but interestingly #steroid and SLEDAI ⬇️. More works needed to identify suitable pts for taper and regime #EULAR2021 #POS0107 @RheumNow https://t.co/Gwe7mPWPdY
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
In a UK 🇬🇧 study of newly diagnosed #SLE, Dr Yee reported higher damage in the first 3yrs but then stabilised. Death rate in the first 12yrs had improved to 4.8% (mostly heart disease and infection) but could still occur early (within 5yr diagnosis) #EULAR2021 #POS0111 @RheumNow
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
In patients with #SLE who attained LLDAS, a retrospective cohort study by Dr Cunha identified predictors of flares including anti-RNP +ve, concomitant immunosuppressant and oral prednisolone. Important to account these during follow-up #EULAR2021 #POS0105 @RheumNow
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Hello @IainBMcInnes1, and thanks for your president's welcome to the #EULAR2021 portal!
Clean and straightforward, I like it. No tour required! @eular_org @RheumNow https://t.co/RDRl4FhEZj
David Liew drdavidliew ( View Tweet)
Starting Thursday we'll be covering EULAR. Tune in for coverage on KOL perspective highlights, clinical trial highlights and much more. https://t.co/L7ryiQ5HdV
Dr. John Cush RheumNow ( View Tweet)
Do look out for Abst #OP0057 today 2/6/21 1645 CEST #EULAR2021. We propose a data-driven algorithm for #rituximab maintenance in #ANCA #vasculitis to avoid excessive retreatment and low IgG @RheumJArn @edvital P. Emery @LeedsMedHealth @LTHTResearch @LeedsHospitals @LeedsBRC https://t.co/XRR0NFnpMu
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Don’t forget to detect cardiac abnormalities in your #RA and #PsA patients! Systematic transthoracic echocardiogram show higher prevalence of diastolic dysfunction, mild mitral and pulmonary valve regurgitation vs. matched controls. #EULAR2021 @RheumNow #POS1392 https://t.co/UsvbEKBRUY
Aurelie Najm AurelieRheumo ( View Tweet)
Result from the #EULAR2021 recommendations on management of RMD in COVID update SLR: No evidence that people with RMDs present an increased risk of contracting COVID19, consistent with the initial Recos. @RheumNow https://t.co/2Q0s3ZKJOP
Aurelie Najm AurelieRheumo ( View Tweet)
🚨So after LoVAS
Now this
Ritux + MMF + Pulse MPS
No oral steroids 🤯
@ARD_BMJ
@EBRheum - Lesser is better ??
https://t.co/CYMNX8wLtd https://t.co/NtwTas3ZdS
EnvisionRheumat ERheumat ( View Tweet)
Positive RCT of Rituximab in Systemic sclerosis https://t.co/WsDZeollu0
Richard Conway RichardPAConway ( View Tweet)
Oh, this is a bummer. #EULAR2021 @RheumNow https://t.co/abdEXPU3Bh
Eric Dein ejdein1 ( View Tweet)
Dr Atienza-Mateo presents on IFX ADA TCZ in Behcets refractory uveitic cystoid macular oedema. All appear effective! @RheumNow #EULAR2021 Abstr#OP0060 https://t.co/Vpju0IvrC5
Richard Conway RichardPAConway ( View Tweet)
Dr Mekinian presents data showing TCZ and TNFi appear equally effective in TAK, complete response 66% vs 70% at 6 months @RheumNow #EULAR2021 Abstr#OP0068
Richard Conway RichardPAConway ( View Tweet)
Dr Kragsnaes presents counter-intuitive data on the gut microbiome. Faecal microbiota transplant ineffective in treating active peripheral psoriatic arthritis, leading to WORSE outcomes. But maybe this also tells us something? @RheumNow #EULAR2021 Abstr#OP0010 https://t.co/nvDvO4Gfxc
Richard Conway RichardPAConway ( View Tweet)
Promising preclinical data of novel dual BAFF/APRIL inihibitor ALPN-303 re:efficacy & immunomodulatory activity vs TACI-i. Could deplete plasma cell compared to anti-CD20 mAbs in #SLE. Be interesting to see how it’ll fare in future clinical trials #EULAR2021 #OP0039 @RheumNow https://t.co/LnQzO67gwI
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Dr Sanchez-Bilbao presents surprising data that tocilizumab may improve even permanent vision loss in GCA @RheumNow #EULAR2021 Abstr#OP0065 https://t.co/oFGNZ04oKr
Richard Conway RichardPAConway ( View Tweet)
ProDERM OP0008: IVIG 2g/kg q4w for dermatomyositis vs PBO, open-label extension. TIS score responders 78% vs 43%. IVIG great option: Not immunosuppressive and works fast, watch for headache, pyrexia, nausea, risk of VTE. #EULAR2021 @RheumNow https://t.co/m4CEkg3EyC
Eric Dein ejdein1 ( View Tweet)
We know smoking is ass w/ RA. How about passive 🚬? French E3N-EPIC cohort: OP0012. Prospective questionaries of 80,000F, 698 incident cases. ⬆️ risk in passive childhood and adult tobacco exposure. #EULAR2021 @RheumNow 🚭! https://t.co/1Rf0euz3VC
Eric Dein ejdein1 ( View Tweet)
