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VITAL Study - Autoimmune Prevention Requires Continued Supplements
In the 2 years that followed the termination of the VITAL study, the preventative effect of vitamin D on incident autoimmune disease disappeared with supplement discontinuation; but n-3 fatty acid treated individuals had a sustained benefit in reducing the risk of autoimmune disease.
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Pre-Treatment Testing with Biologics Falls Short
US commercial insurance claim analysis of laboratory screening and monitoring practices in chronic inflammatory skin disease (CISD) patients shows that < 60% received the recommended pretreatment testing when starting systemic immunomodulatory treatment.
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Half of Subclinical Synovitis Patients May Remit
Ultrasound subclinical synovitis is found in a third of individuals at risk of rheumatoid arthritis (RA) patients; in half of these, subclinical synovitis resolves with a favorable outcome.
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Study of 78 #RA pts(83% CCP+) showed signif. discordance between office visit DAS scores & telephone eval by RAPID3 (w/in 2 wks of F2F visit). By RAPID3, 27% were in remission, vs F2F DAS-CRP 71%) or DAS-ESR (33%) kappa= 0.48 (mod) & 0.14 (low agreement) https://t.co/DsgR0aMUGf https://t.co/smnFe13m5W
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Dr. John Cush RheumNow ( View Tweet)
Study of 235 newly Dx #RA patients (157 females) found that 11 pts (5%) had carpal tunnel syndrom (CTS) at the time of initial RA diagnosis. Such pts were more likey to be older, female, CCP negative and have a longer Sx duration. https://t.co/Nny9HSD5zX https://t.co/2Dnhrjz8ud
Dr. John Cush RheumNow ( View Tweet)
240 consecutive estab. RA pts underwent cervical spine X-rays looking for ant. atlantoaxial subluxation (aAAS >3 mm); aAAS found in 25 (10.4%) mean interval =4.2mm. One-third had no neck pain. aAAS predicted by lower BMI, CCP, erosions & joint prostheses https://t.co/VTMdv6wudB https://t.co/RDbjjuJAjD
Dr. John Cush RheumNow ( View Tweet)
Greek study finds 251/1264 #RA pts (20%) had difficult to treat RA (D2T). D2T Predictors were Younger age, fibromyalgia, OA, no change in DAS28-ESR in 1st 6mos b/ts-DMARD Rx. Mental-/pain-/metabolic-Dz contributed to LT worsening https://t.co/A5bfth79L2 https://t.co/f5AOvFW9Yu
Dr. John Cush RheumNow ( View Tweet)
Metabolic Syndrome increases RA risk. UK Biobank (369,065) study saw 4901 incident RA (12 yrs F/U). Signif hi RA risk with MetS (HR 1.22), waist circumf (1.21), incr TG (1.12), decr HDL (1.31) & hyperglycemia (1.15) - all additive. https://t.co/jN15axxTmu https://t.co/DP5bFwOB3F
Dr. John Cush RheumNow ( View Tweet)
Study of 235 newly Dx #RA patients (157 females) found that 11 pts (5%) had carpal tunnel syndrom (CTS) at the time of initial RA diagnosis. Such pts were more likey to be older, female, CCP negative and have a longer Sx duration. https://t.co/Jb3hynyqGx https://t.co/EbTvHGq5Yk
Dr. John Cush RheumNow ( View Tweet)
Prevalence of Cardiovascular Disease in Rheumatoid Arthritis
A prospective study of the BioSTAR registry estimates the prevalence of cardiovascular disease in rheumatoid arthritis (RA) to be 4.6%.
https://t.co/NRn0DrYoBX https://t.co/qOoTmBNB1p
Dr. John Cush RheumNow ( View Tweet)
Clinical implications of immune aging.
Connie Weyand.
#RNL2024
@RheumNow https://t.co/QUbvkIvPco
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Stressed ER is a major TNF producer.
Connie Weyand.
#RNL2024
@RheumNow https://t.co/zsSD8XWFcP
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Consequence of aged immune system.
Connie Weyand.
#RNL2024
@RheumNow https://t.co/gfCTfzulR9
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Inflammation or Inflammaging? The aging immune system in the host predisposes the development of RA, Cornelia Weyand, #RNL2024 @RheumNow https://t.co/30Zbf8kRXs
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Dr. Antoni Chan synovialjoints ( View Tweet)
Aging in RA: "(RA) is due to a poorly functioning immune system which increases a patients risk of CVD, infection, and cancer. The aging immune system additionally affects this process. We must consider this clinically, we must protect our aging patients without over… https://t.co/TlHyTxPMNc https://t.co/JBVg4uqn6A
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Dr. Rachel Tate uptoTate ( View Tweet)
#RNL2024 @RheumNow
As we age, we gain not just wisdom, but also "Inflammaging"
Immune system changes in our inflammatory cells lead to:
- Poor vaccine response
- High risks for infections
- High risk for CVD
- High risk for autoimmunity https://t.co/golMAPR0ZI
Eric Dein ericdeinmd ( View Tweet)
Useful resource on dietary guidance in RA from @ACRheum focusing on a MD-like diet #RNL2024 @RheumNow https://t.co/QplaQ1caxv.
Dr. Antoni Chan synovialjoints ( View Tweet)
Vit d and omega 3 reduces incidence of RA.
Hani El Gabalawy.
#RNL2024
@RheumNow https://t.co/BGGbLvMhhT
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Good number of ACPA positive patients reverts to ACPA negative in 5 years.
Hani El Gabalawy.
#RNL2024
@RheumNow https://t.co/yLxO0ulsam
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Dr. Kavanaugh: "Role of alcohol on inflammation? It's part of the Mediterranean diet!"
Dr. Guma:"The data is mixed; polyphenols may be beneficial; alcohol in limited quantities was allowed in studies"
Dr. Weber:" Be careful w/EtOH in pts w/palpitations"
#RNL2024 @rheumnow
TheDaoIndex KDAO2011 ( View Tweet)
