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ANAGO Study - Anakinra for Gout Flare

d MedPage Today

The interleukin (IL)-1 receptor antagonist anakinra (Kineret) was not superior to triamcinolone for relieving gout flares, but had similar effects for pain reduction as the glucocorticoid, a randomized phase II study found.

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Diagnosis & Treatment of Osteoarthritis Reviewed

d Jack Cush, MD

Katz, Arant and Loeser have published a comprehensive open-read overview of osteoarthritis (OA) of the hip and knee in JAMA; underscoring the impact, advances, disappointments and guidelines put forth. 

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Lung Preservation with Tocilizumab in Early Systemic Sclerosis

d Jack Cush, MD

Arthritis & Rheumatology has published the results of a subanalysis from tocilizumab (TCZ) clinical trials showing that Il-6 inhibition was associated with preservation of lung function patients with early systemic sclerosis (SSc).

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We are excited to announce that Jeff Sparks ( @jeffsparks) will be leading a discussion on ILD in RA at RheumNow Live this March. Register to attend today. https://t.co/uwxOVh142F https://t.co/bnittqkhKQ

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Lung Preservation w/ Tocilizumab in Early Systemic Sclerosis Arthritis & Rheumatology has published the results of a subanalysis from TCZ clinical trials showing that Il-6 inhibition is related with preservation of lung function patients with early SSc. https://t.co/2BwWQWEkri https://t.co/pjVc8YTDwU

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Dr. John Cush RheumNow ( View Tweet)
QD Clinics- The Sawtooth Steroid Taper Sawtooth Steroid Taper Surgery Rules for DMARDs & Biologics RA & DVT Traveling to Medical Meetings during COVID Hemoptysis and SLE When to do Genetic Testing in Febrile Patients https://t.co/dZLqGUyizG https://t.co/PYsH7K6ByB

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Dr. John Cush RheumNow ( View Tweet)
A San Paolo study of the relevance of anti-Jo-autoAbs in 118 dermatomyositis patients; 8.5% of whom were Jo-1 positive. Jo-1+ had more "mechanic's hands," joint and lung disease; & low/no chance for remission and more steroid & immunosuppressive use https://t.co/yv51txWZCa https://t.co/fLu4PH0e9C

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Dr. John Cush RheumNow ( View Tweet)
Rumor has it I won the"Slow Bike Race" in 3rd grade at field day. How to win the Slow Bike Race? Slow and steady, Focus, Balance, Economy of Effort, Think More-Pedal Less and Pay No Attention to the Competition. https://t.co/04XbS5FSlK
Dr. John Cush RheumNow ( View Tweet)
Data from Danish Medical Birth Register shows PREG women w/ spondyloarthritis have more adverse pregnancy outcomes - including preterm birth (OR 1.5), elective C-section (OR 1.44), & epidurals (OR 1.11). Not increased were preeclampsia & rate small wt. https://t.co/opYsOBAR6A

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Survery of 438 RHEUMS on #AS & SpA - half use mod NY & ASAS criteria. 3/4 say Inflammatory Back Pain is axSpA specific, ~1/2 say uveitis/dactylitis are “very specific; less so heel enthesitis, peripheral arthritis. SI MRI was mor common w/ younger Rheums https://t.co/xfjvK5TO0t

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Dr. John Cush RheumNow ( View Tweet)

Medscape has published the 2021 Rheumatologist Lifestyle, Happiness & Burnout Report. Happy went down during COVID 79% to 49% 32% burnt out; 11% depressed 51% have workplace issues Half take 3-4 wks vacation https://t.co/g8UAHtiLIB

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Dr. John Cush RheumNow ( View Tweet)

Single center study of 43 pregnant SLE pts (57 pregnancies) - 96.5% intended to breast feed & 72% did (same as gen population). But SLE women had more early discontinuations @ 3 mos (assoc w/ smoking, BMI, joint Dz) HCQ assoc w/ longer breastfeeding https://t.co/VVVTVUeOT5

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Dr. John Cush RheumNow ( View Tweet)

Population based study of smoking cessation & risk of TKR in knee OA. TKR higher in recent quitters (26.7/1000PY vs 17.4/1000PY in smokers). adjusted HR=1.30 (95%CI:1.05-1.59). TKR risk was higher among quitters with weight gain (HR=1.42) https://t.co/6onQWQeFcI

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CTD associated pulmonary HTN has improved sincd 2010. Metanalysis of 11 RCTs (4,329 pts) & 19 registries (9,739 pts); 5 RCTs find PAH Rx assoc w/ 36% lower mortality/morbidity. Registry data shows better PAH survival since 2010 (73% vs 65% @3yrs) https://t.co/0BkO70AQfi

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Analysis of incident #RA in UK Clinical Practice registry shows recent prednisone >=7.5mg/d is assoc w/ hypertension in RA. In 17760 RA pts, 42% were Rx steroids; recent GC yielded a 17% increase in HTN (HR 1.17); only >7.5mg/D implicated https://t.co/qUKs2oZZUV https://t.co/pWmD4nKs6U

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QD Clinic - When to do Genetic Testing in Febrile Patients Indications for Genetic testing for autoinflammatory disorders https://t.co/1vnR1JQAxZ https://t.co/x2wyLHhjgN

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Dr. John Cush RheumNow ( View Tweet)
QD Clinic - Hemoptysis and SLE Key Features of Alveolar Hemorrhage in lupus https://t.co/qNZYDYmn70 https://t.co/sitc7Tlf5V

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Dr. John Cush RheumNow ( View Tweet)
RheumNow Podcast is now up! Systemic Sclerosis Pearls Dr. Jack Cush reviews nearly a dozen news and journal reports from the past 2 weeks on https://t.co/fxtCOkxTER, https://t.co/nKRmKWR0Bd https://t.co/ESdycxLoCz

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Dr. John Cush RheumNow ( View Tweet)
High Risk Cancer Profiling with Inflammatory Myositis A recent metanalysis of studies suggest you may be able to use certain clinical factors to stratify cancer risk in patients with idiopathic inflammatory myopathies (IIMs). https://t.co/TjmdGtdDQG https://t.co/tlfVU031fY

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QD Clinics - Traveling to Medical Meetings during COVID Is it Safe to Travel? https://t.co/flELrZbjnw https://t.co/ixebtW71fx

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Dr. John Cush RheumNow ( View Tweet)
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