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#EULAR2020 #op0202-hpr 🇬🇧 study remind that resistant training benefits patients with inflammatory arthritides: improved function, wellbeing, self-efficacy, strength and fatigue.improved balance&endurance helps prevent falls @RheumNow https://t.co/MH7VD6zH9t
Olga Petryna DrPetryna ( View Tweet)
#EULAR2020 #op0143 a nationwide study concludes GCA pts at higher risk for sarcoma (HR 2.14), kidney cancer (1.6), hematological malignancies (HL2.42&non-HL1.66). Overall cancer HR 1.29. Time to diagnosis shorter in GCA (~48mo) vs controls (~58mo) @RheumNow https://t.co/obAlZw2gei
Olga Petryna DrPetryna ( View Tweet)
#EULAR2020 #op0148 real world European study of Mepolizumab in 142 pts w/EGPA shows significant improvement of general, ENT, pulm&neuro symptoms. Significant reduction in BVAS, 90%decrease of asthma attacks by 12 mo, decreased steroid use. 21.1%non-serious AEs @RheumNow https://t.co/fN4tKPvUaE
Olga Petryna DrPetryna ( View Tweet)
#eular2020 #op0227 52 wk SEC vs ADA H2H EXCEED trial: Acr20 67.4%SEC vs 61.5%ADA. Better retention of SEC at 85.7% vs 76.3%ADA. SEC significantly outperforms in PASI90 (65.4 SEC be 43.2 ADA) @RheumNow https://t.co/M8UGydTFDF
Olga Petryna DrPetryna ( View Tweet)
#eular2020 #op0314 5 y drug-free remission (5DFR) is rare in early AxSpA: 17%pts from DESIR cohort reach 5DFR. Shorter disease duration (<1.3y), lower BASDAI&ASAS-CRP & less peripheral involv more likely to achieve DFR. Imaging and biological data did not predict DFR @RheumNow
Olga Petryna DrPetryna ( View Tweet)
EULAR2020 #op0168 🇰🇷Population-based cohort study identifies both allopurinol& febuxostat associated with MI, cerebral infarction&cerebral hemorrhage. Fluctuation of sUA&potentially even cardiovascular gout attacks (urate crystals in vasculature) as possible causes @RheumNow https://t.co/mcb5NLnMq1
Olga Petryna DrPetryna ( View Tweet)
#EULAR2020 #op0028 12 wk ph3 RELIEF study: Apremilast effectively relieves OU pain and OU number after 12 wks of 30 mg bid Rx. Great proportion of APR PTs achieved >10 mm &>30 mm improvement in OU pain @RheumNow https://t.co/p71sz9XL0e
Olga Petryna DrPetryna ( View Tweet)
#EULAR2020 #op0327 AI stages knee OA radiograpgic chsnges ieth accuracy 91.8-99% in 95% of the cases. Would you prefer AI or human radiology readings for MSK imaging ? @RheumNow
Olga Petryna DrPetryna ( View Tweet)
LVV=Large vessel vasculitis
Dr. John Cush RheumNow ( View Tweet)
Do patients with early RA need to see a rheumatologist in the first 6w after Sx onset, or will 12w do?
Getting in before 6w is better for drug-free remission than 12w, but not for radiographic progression - although >12w is too long!
Leiden/ESPOIR OP0222 #EULAR2020 @RheumNow https://t.co/uaLsK4TMSR
David Liew drdavidliew ( View Tweet)
Here's the data for GCA (even though labelled PMR) using the same methods, both looking at first 1y.
Here's what gets me - it's obviously worse, but not that much worse... everyone's looking for steroid-sparing agents in GCA, but PMR's left behind?
OP0275 #EULAR2020 @RheumNow https://t.co/YWkNBVitGa
David Liew drdavidliew ( View Tweet)
For your new diagnosis RA patients, how long have they typically had symptoms for by the time they first see you?
#EULAR2020 @RheumNow
David Liew drdavidliew ( View Tweet)
Lots of talk about best bDMARDs in RA-ILD, but what about in RA-assoc bronchiectasis?
@Yuz6Yusof found rituximab had better 'lung survival' vs TNFi (similar baseline stats)
Something to consider in these difficult-to-treat pts?
@LeedsBRC Newcastle THU0143 #EULAR2020 @RheumNow https://t.co/XpffkDNqhU
David Liew drdavidliew ( View Tweet)
For patients on bDMARDs having surgery, we worry about post-op delayed wound healing.
In this Japanese cohort, TCZ use was a risk factor.
Unclear if meds withheld, but given IL-6 upreg in wound healing, it's plausible TCZ might have worse outcomes??
SAT0047 #EULAR2020 @RheumNow https://t.co/HVIKPplwiA
David Liew drdavidliew ( View Tweet)
Behcet's ulcers can be a real pain.
I've heard pentoxifylline gel be discussed before, here's some early data to back it up (need bigger trial).
Tastes terrible, though - so maybe this?
https://t.co/TrSlIKdWX3
(or a commercial prep might solve it)
SAT0260 #EULAR2020 @RheumNow https://t.co/lvDY39ZbIH
David Liew drdavidliew ( View Tweet)
New genome wide association study on anterior uveitis. Heritability for uveitis is 0.7, much greater than axSpA. Includes great data on genetic risk scores @ARVOiovs @AberdeenEpi @hteraG_senoJ https://t.co/gsX39YfrbN https://t.co/e8qBpL5xwy
Dr Philip Robinson philipcrobinson ( View Tweet)
It is also important that I recognise the critical role of the @ACRheum and @eular_org to @rheum_covid as well as many other supporting organisations. Their contributions have been instrumental. We now also have corporate sponsors. Thank you all https://t.co/T15q5OwTLK
Dr Philip Robinson philipcrobinson ( View Tweet)
So maybe the optimal dose for psoriasis with UPA in PsA was tested? UPA works in PsA so another potential Rx for pts LB0001 @eular_org #EULAR2020 @RheumNow @CRASCRRheum @earlyarthritis https://t.co/GiT7H91umA
Janet Pope Janetbirdope ( View Tweet)
Whom with GCA should receive tocilizumab? What happens when it is stopped? Optimal dose for maintenance weekly or Q2 weekly? GiACTA gives only some answers. Need RWE #EULAR2020 @eular_org @RheumNow @CRASCRRheum @earlyarthritis #vasculitis https://t.co/aNvR14vfEV
Janet Pope Janetbirdope ( View Tweet)
What dose/frequency of rituximab do you use in maintenance ANCA #vasculitis? @RheumNow @eular_org @CRASCRRheum @earlyarthritis #EULAR2020
Janet Pope Janetbirdope ( View Tweet)