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#EULAR2020 Recc for irAEs w/ICI:
1. GC's ok, goal<10 mg/d, any csDMARD, bDMARD (TNFi/IL-6),🚫ABT xcept life-threatening myositis
2. Myositis beware bulbar signs: dysphagia, dysarthria, dysphonia: stop ICIs,⬆️GC, IVIG/PE
3. Don't test autoAbs b/f ICI Rx
https://t.co/P5jDgnjK94
k dao KDAO2011 ( View Tweet)
Can you classify SLE by labs only but should you? Serology is part of criteria but why dx with only +ANA, +antiDNA and no other CTD characteristics. Would need cytopenias & RBC casts to think of lab dx of SLE OP0094 @LupusCanada @RheumNow @eular_org #EULAR2020 @CRASCRRheum https://t.co/Jr6SRr3HR1
Janet Pope Janetbirdope ( View Tweet)
My brush with COVID- heart-breaking and inspirational. A story about Larry and Jessica. https://t.co/zZTmwcmRe0
Links:
Dr. John Cush RheumNow ( View Tweet)
Avacopan is as effective as steroids in ANCA Assoc Vasculitis – 330 pt RCT AAV Rx w/ RTX or CTX but randomized to prednisone or avacopan (C5aR antagonist). Avacopan=prednisone remission rates same (72% vs 70%) wk 26 & wk 52 (66% vs 55%). #EULAR2020 #OP0011 https://t.co/WIXJCYkxSb
Links:
Dr. John Cush RheumNow ( View Tweet)
OU=Oral Ulcers https://t.co/1LPye7ohM1
Dr. John Cush RheumNow ( View Tweet)
Do not be tempted to stop MTX or other DMARDs perioperatively! They probably help rather than harm #EULAR2020 https://t.co/jb4ZuZlqSu
Christos Koutsianas Dr_C_Koutsianas ( View Tweet)
RA pt not responding to a 1st biologic; what you predict in a Head to Head - Abatacept vs Upadacitinib?
Dr. John Cush RheumNow ( View Tweet)
#EULAR2020 #op0225 sub study of OPAL Balance: withdrawal of MTxdoes not negatively impact Tofa efficacy in PsA. At 6 mo deltaPASDAS 0.229 (0.079) for tofa mono & 0.q138 (0.081) for tofa+mtx. LFT elevation more common in combination arm @RheumNow https://t.co/NO1agViScD
Olga Petryna DrPetryna ( View Tweet)
#EULAR2020 #fri0505 Still’s pts who are able to achieve remissions w/longer itnervals btw tocilizumab infusions & lower dose of prednisone more likely to successfully withdraw Toci. Time to symptom recurrence in relapse group 7.8 mo. Older pts more likely to relapse @RheumNow
Olga Petryna DrPetryna ( View Tweet)
OU=Oral Ulcers https://t.co/1LPye7ohM1
Dr. John Cush RheumNow ( View Tweet)
Main factors influencing #physicalactivity in inflammatory #arthritis patients are psychological
➡️Main factor related to knowledge of benefits of #exercise & symptoms
➡️Modifiable
➡️Health professional support key
FRI0642-HPR #EULAR2020
👉🏽https://t.co/Vdc7rjnC6Y
by @DavergneT https://t.co/aMUHA5IMrn
Dr Ai Lyn Tan DrAiLynTan ( View Tweet)
@Janetbirdope @eular_org @RheumNow @CRASCRRheum @earlyarthritis Good question. I suspect it may be a class effect but would be good to see H2H btw JAKs one day. If selective JAK 1 inhibition provides more, less or same efficacy is still not clear to me
Olga Petryna DrPetryna ( View Tweet)
Don’t forget significant fibrosis with ILD has +RCT with nintedanib INBUILD study. Lots of buzz of RA ILD where MTX is OK, TNFi may have more ILD than other bDMARDs, biomatkers KL-6 @eular_org OP0038 #EULAR2020 @CRASCRRheum https://t.co/OihF3LmNYQ
Janet Pope Janetbirdope ( View Tweet)
#EULAR2020 OP0096 Dr. L Chatzis study on Sjogren:
1. 2nd most common autoimm dz in women
2. women:men ratio 20:1 (not 9:1)
3. 2 types Ro-Ab: nuc. Ro60 (assc w/La)and cytopls. Ro52 (assc w/ILD/myositis)
4. Seroneg. Sjogren's (neg Ro/La/RF) good prognosis:⬇️lymphoma
@RheumNow https://t.co/fV3ltQqnkf
k dao KDAO2011 ( View Tweet)
NPSLE is more than a headache! probs with dx, uncertain Rx, overlap with common probs - infection, pain, fibromyalgia, drug side effects, etc. Spectrum in NPSLE just like SLE has a spectrum of cutaneous findings T Huizanga discusses @eular_org #EULAR2020 @RheumNow @CRASCRRheum https://t.co/sdw0xavWBq
Janet Pope Janetbirdope ( View Tweet)
Dan Clauw: obese patients with chronic pain reported improved pain levels very early with low calorie diet, long before weight loss, suggesting the diet may be having a more direct effect. https://t.co/aZDOtBd9mz
Stefan Siebert StefanSiebert1 ( View Tweet)
Majority are correct. 1/3 of SAPHO meet PsA criteria esp if no osteitis @RheumNow @eular_org @CRASCRRheum @earlyarthritis #EULAR2020 https://t.co/B9wp8JxWpI
Janet Pope Janetbirdope ( View Tweet)
What % of SAPHO pts do you think have PsA? More if synovitis Less if osteitis #EULAR2020 @eular_org @RheumNow @CRASCRRheum AB0038
Janet Pope Janetbirdope ( View Tweet)
When making a dx of neuropsychiatric SLE I order labs AND @RheumNow @eular_org @CRASCRRheum @earlyarthritis #EULAR2020
Janet Pope Janetbirdope ( View Tweet)
#Upadacitinib #psoriaticarthritis Upa works in PsA including imaging and when they show it surprising good PASI scores as well https://t.co/ZWqj8ythHB
Peter Nash drpnash ( View Tweet)