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Long Term Safety and Efficacy of Tacrolimus in Lupus Nephritis

d Jack Cush, MD

Takeuchi et al has published their large experience with long-term tacrolimus use in lupus nephritis patients showing its real-world safety and efficacy.

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Delays in Diagnosis of Axial Spondyloarthritis

d Jack Cush, MD

The diagnosis of axial spondyloarthritis (and anklylosing spondylitis) (axSpA) is often delayed and usually not diagnosed by rheumatologists; a recent metanalysis shows that longer delays were attributable to lower education levels, younger age at onset and absence of extra-articular manifes

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Hydroxychloroquine Shortage During COVID-19

d Jack Cush, MD

According to a recent report in Annals of Rheumatic Disease, public enthusiasm for hydroxychloroquine (HCQ) created significant access issues for rheumatic patients in the early phases of the COVID-19 pandemic.

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Adipose Transplants as a New Regulator of Osteoarthritis

d Jack Cush, MD

A novel report from PNAS suggests that in osteoarthritis (OA), the damage is not entirely from body weight and mechanics, instead it may be from adipose tissue itself.

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Chinese SLE CSTAR study of 4792 SLE patients, of whom 374 (7.8%) had scarring alopecia. Risk factors for scarring alopecia included mucocutaneous lesions (OR 2.1) high SLICC/ACR-DI (OR 1.4), & positive Sm (OR 1.4), but less seen w/ renal CV involvement https://t.co/Y466WK3shS

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Survey of 428 Rheums in Brazil finds they are prone to promote physical activity; but less than 1/4 had training, 14% dont assess phys activity routinely, & half dont know minimum recommendations. Major gaps in knowledge about physical activity recs exist https://t.co/7WwuR0bqpJ

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Telemedicine study on accuracy of Pt reported swelling predicting inflamm arthritis. 1637 pts w/ 13 wks of Sxs. 76% pts reported swelling, but only found by 41% of Rheums. Pt reporting sensitivity was was 87%, but specificity only 31%; PPV=46%, NPV=77% https://t.co/oV3p06BHRj

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New year, new QD Clinic- Clinic Emergencies. https://t.co/xyaVP8ZkmB https://t.co/QXTvp2mttV

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Study of 52 pts w/ pericardial dz in GCA (44) & PMR (8) finds only 46% were >70 yrs. Manifest as pericardial effusion (85%), was initial Sx in 37%. 69% were symptomatic & classic cranial Sxs present in only 40%. Tamponade more likely w/ PMR https://t.co/B5IxBT9OO7

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Adipose Transplants as a New Regulator of Osteoarthritis--A novel report from PNAS suggests that in osteoarthritis (OA), the damage is not entirely from body weight and mechanics, instead it may be from adipose tissue itself. Read more: https://t.co/0VpR4VPmBX https://t.co/jSALMKXrhB

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147 Obese patients (25 w/ gout, 55 w/ hyperuricemia) had bariatric surgery. 1 yr after sugery, pts lost mean 31 kg & decreased uric acid from 419 to 308 µmol 1–7 days postop and 328 @12 mos (P < 0.001). 40% of gout pts were at/below target. https://t.co/9e8zpWKHay

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Download your RheumaKnowledgy Card https://t.co/L7O0UFjEBV https://t.co/iFtVKERnjC

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Corticosteroid Use Hikes CV Risks in Rheumatic Patients--It is long known that high-dose steroids may increase the risk of cardiovascular disease (CVD), heart disease, stroke, or other vascular outcomes, but it is unknown what the risk is at lower doses. https://t.co/gkTLP3ceVD https://t.co/HMpvpham1q

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Medicare's 'Most Favored Nation' Drug-Pricing Rule in Limbo--The fate of the Trump administration's "most favored nation" (MFN) rule for bringing down prescription drug prices remains uncertain as President-elect Joe Biden prepares to assume office. https://t.co/3NnvyRiVDo https://t.co/gLSFERaNku

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SOBI announced Kineret is now FDA approved to treat DIRA (defic of IL-1 receptor antagonist), an ultra-rare, autoinflammatory Dz caused by a genetic mutation in the IL1RN gene,. Pts have life-threatening systemic inflammation with skin and bone involvement https://t.co/iccvWYJva9

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National Psoriasis Foundation Task Force updated their COVID-19 guidance statements. Including Guidance 4.6, stating PsA pts who receive a mRNA-COVID vaccine should continue their biologic or oral therapies as they manag of their psoriatic disease https://t.co/byujtDET33

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Retrospective study of 171 GCA patients found that 32% had aoritis (by Sxs or AI murmur); hese pts were 6 fold more likely to have subsequent Aortic complications (aortic aneurysms or dissection) https://t.co/zRVzmnU7JH

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After your 2 doses of COVID vaccine, YES you need to continue to wear a mask, cont. hand washing & social distancing - so as to continue to protect yourself and others. While vaccinated you can still become infected and spread infection. https://t.co/TkcSNx0hF1

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A oatint infected with COVID-19- Yes they should get vaccinated ~90days after infection has resolved.Antibody testing is not needed before you are vaccinated. Evidence suggests that reinfection is uncommon in the 90 days after initial infection. https://t.co/TkcSNx0hF1.

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Preprint results of the REMAP-CAP trial in the UK shows that IL-6 inhibitors, when given within 24 hrs of ICU entry for COVID-19, lowers mortality rate by 36%. Hosp mortality in 353 TCZ was 28%, 48 sarilumab was 22% in 402 controls was 36%. https://t.co/fkjOz99t0l

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